It is now just 20 years ago since Sodi-Pallares (1962) produced his provocative idea that myocardial ischemic damage could be minimized by replacing potassium loss from ischemic cells by a solution of glucose-insulin and potassium. Although his ideas are still being evaluated, it is interesting to see how even controversial concepts can lead to the evolution of new and important hypotheses.
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References
Corr, P. B., Gross, R. W., Sobel, B. E., (in press), Arrhythmogenic amphiphilic lipids and the myocardial cell membrane, Editorial, J.Mol.Cell.Cardiol.
Dalby, A. J., Bricknell, O. L., and Opie, L. H., 1981, Effect of glucose-insulin-potassium infusions on epicardial ECG changes and on myocardial metabolic changes after coronary artery ligation in dogs, Cardiovasc.Res.., 15:588–598.
de Leiris, J., Opie, L. H., and Lubbe, W. F., 1975, Effects of free fatty acid and glucose on enzyme release in experimental myocardial infarction, Nature 253:746–747.
Heng, M. K., Norris, R. M., Peter, T., Nisbet, H. D., and Singh, B. N., 1978, The effects of glucose-insulin-potassium on experimental myocardial infarction in the dog, Cardiovasc. Res. 12:429–435.
Katz, A. M., (in press), Membrane-derived lipids and the pathogenesis of ischemic myocardial damage, Editorial, J.Molec.Cell. Cardiol.
Kurien, V. A., Yates, P. A., and Oliver, M. F., 1971, The role of free fatty acids in the production of ventricular vulnerability following acute coronary artery occlusion in the dog, J.Molec.Cell.Cardiol.. 11:31–34.
Liedtke, A. J., Nellis, S. H., and Whitesell, L. H., 1982, Effects of regional ischemia on metabolic function in adjacent aerobic myocardium, J.Molec.Cell.Cardiol. 14:195–205.
Oliver, M. F., Kurien, V. A., and Greenwood, T. W., 1968, Relation between serum free fatty acids and arrhythmias and death after myocardial infarction, Lancet 1:710–715.
Rackley, C. E., Russell, R. O., Rogers, W. J., Mantle, J. A., and McDaniel, H. G., 1979, Glucose-insulin-potassium infusion in acute myocardial infarction. Review of clinical experience, Postgrad.Med.. 65:93–99.
Rovetto, M. J., Lamberton, W. F., and Neely, J. R., 1975, Mechanism of glycolytic inhibition in ischemic rat hearts, Circ.Res. 37:742–751.
Russell, D. C, and Oliver, M. F., 1979, The effect of intravenous glucose on ventricular vulnerability following acute coronary artery occlusion in the dog, J.Molec.Cel.Cardiol. 11:31–44.
Sobel, B. E., Corr, P. B., Robison, A. K., Goldstein, R. A., Witkowski, F. X., and Klein, M. S., 1978, Accumulation of lysophosphoglycerides with arrhythmogenic properties in ischemic myocardium, J.Clin.Invest. 62:546–553.
Sodi-Pallares, D., Testelli, M. R., Fishleder, F. L., Bisteni, A., Medrano, G. A., Friedland, C., and De Micheli, A., 1962, Effects of an intravenous infusion of a potassium-glucose, insulin solution on the electro-cardiographic signs of myocardial infarction. A preliminary clinical report, Amer.J. Cardiol. 9:166–181.
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© 1984 Springer Science+Business Media New York
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Opie, L.H. (1984). Substrate Effects in Myocardial Ischemia. In: Chazov, E.I., Smirnov, V.N., Oganov, R.G. (eds) Cardiology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-1824-9_54
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DOI: https://doi.org/10.1007/978-1-4757-1824-9_54
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