To understand the relationship between the nervous system and ventricular fibrillation, the leading cause of sudden death, is a key factor to comprehend the underlying pathophysiologic mechanisms, to establish rational preventive measures, and to improve the early identification of high risk patients. Considerable progress has been made during the last decade1,2,3 and some of the main points will be mentioned here, including the problem of adequate animal models for sudden death, the role of psychologic stress, of the cardiac sympathetic nerves and of the vagi, and the potential for autonomic reflexes to be used for the identification of high risk subgroups.
KeywordsSudden Death Sudden Cardiac Death Ventricular Fibrillation Ventricular Tachyarrhythmia Exercise Stress Test
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- 1.P. J. Schwartz, A. M. Brown, A. Malliani, and A. Zanchetti, “Neural Mechanisms in Cardiac Arrhythmias,” Raven Press, New York (1978).Google Scholar
- 2.B. Lown, Cardiovascular collapse and sudden cardiac death, in: “Heart Disease,” E. Braunwald, ed., W. B. Saunders, Philadelphia (1980).Google Scholar
- 4.P. J. Schwartz, G. E. Billman, and H. L. Stone, Autonomic interventions in a new animal model for sudden death, Circulation Suppl.IV 64:289 (1981).Google Scholar
- 6.R. L. Verrier, F. Lombardi, and B. Lown, Ef f ects of d if f erent types of behavioral stress on coronary hemodynamics, Fed. Proc. 41:1599 (1982).Google Scholar
- 7.P. J. Schwartz, The long Q-T syndrome, in: “Sudden Death,” M. E. Kulbertus and H. J. J. Wellens, eds., M. Nijhoff, The Hague (1980).Google Scholar
- 8.P. J. Schwartz, Sympathetic imbalance and cardiac arrhythmias, in: “Nervous control of Cardiovascular Function,” W. C. Randall, ed., Oxford University Press, in press (1982).Google Scholar
- 10.G. E. Billman, P. J. Schwartz, and H. L. Stone, Baroreceptor reflex control of heart rate: a predictor of sudden cardiac death, Circulation 66: in press (1982).Google Scholar