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Cardiology pp 45-51 | Cite as

Calcium and Cardiovascular Disease

  • L. H. Opie

Abstract

When the calcium-antagonist agents were initially used by Fleckenstein’s group, it was found that beta-adrenoceptor agonists opposed the specific action of high dose verapamil (10-5M) in inhibiting myocardial contractility (Figure 3 and 7 in Fleckenstein, 1971). The restorative effect of isoproterenol was very similar to that of an increased extracellular calcium (Figure 6 in Fleckenstein, 1971). Thus early thinking saw calcium-antagonists and beta-antagonists as having opposite effects on trans-sarcolemmal calcium flux. Some even argued that the calcium-antagonists had beta-blocking qualities, an argument that was laid to rest when it was found that verapamil was unable to inhibit an isoproterenol-induced tachycardia or inotropic response (Nayler et al, 1968). The explanation was that verapamil could not prevent catecholamine-induced increases in the tissue level of cyclic AMP nor the beta-mediated activation of adenyl cyclase; rather, verapamil blocked the trans-sarcolemmal calcium influx provoked in K+ depolarized hearts by either catecholamines or by an increased external calcium (Watanabe et al, 1974).

Keywords

Calcium Channel Ventricular Fibrillation Coronary Artery Ligation Coronary Ligation Ventricular Fibrillation Threshold 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1984

Authors and Affiliations

  • L. H. Opie
    • 1
  1. 1.MRC Ischaemic Heart Research Unit Department of MedicineGroote Schuur Hospital and University of Cape TownSouth Africa

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