Abstract
The discovery of TXA2 and PGI2 with their antagonistic actions on vessel wall and platelets were unquestionably milestones that fundamentally altered the prevailing ideas on pathophysiology and therapy of cardiovascular diseases.
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S. J. Coker, J. M. Ledingham, J. R. Parratt, and I. J. Zeitlin, Aspirin inhibits both the early myocardial release of thromboxane B2 and ventricular ectopic activity following coronary artery occlusion in dogs, Scot.Med.J. 26: 169 (1981).
M. Tada, T. Kuzuya, M. Inoue, K. Kodama, M. Mishima, M. Yamada, M. Inui, and H. Abe, Elevation of thromboxane B2 levels in patients with classic and variant angina pectoris, Circulation 64: 1107 (1981).
W. Förster, Ef f ect of various agents on prostaglandin biosynthesis and the antiaggregatory effect, Acta Med.Scand. (Suppl.)642:35 (1980).
P. Mentz, K. Pönicke, H. U. Block, Ch. Gießler, K. -E. Blass, B. -L. Bayer, and W. Förster, Stimulierung der prostazyklinbiosynthese als möglicher wirkungsmechanismus van dipyridamol, Arzneim.-Forsch. 31:2075 (1981).
W. Förster, Influence of cardiovascular drugs on platelet aggregation, Adv.in Myocardiol. (in press).
H. -U. Block, W. Förster, and I. Heinroth, SIN-1, the main metabolite of molsidomine inhibits prostaglandin endoperoxide analogue — and arachidonic acid-induced platelet aggregation as well as platelet thromboxane A2 formation, Arzneim.-Forsch. 32; 189 (1982).
W. Sziegoleit, J. Rausch, M. György, E. Dekov, and M. Békés, Influence of acetylsalicylic acid on acute circulatory effects of pindolol in hypertensive patients, in: “Prostaglandins and Thromboxanes,” W. Förster, ed., Pergamon Press, (1981).
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© 1984 Springer Science+Business Media New York
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Förster, W. (1984). Effects of Beta Receptor Blocking Drugs on Prostacyclin (PGI2) and Thromboxane A2 (TXA2) Biosynthesis as a New Aspect of their Mode of Action. In: Chazov, E.I., Smirnov, V.N., Oganov, R.G. (eds) Cardiology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-1824-9_37
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DOI: https://doi.org/10.1007/978-1-4757-1824-9_37
Publisher Name: Springer, Boston, MA
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