Skip to main content

Effects of Beta Receptor Blocking Drugs on Prostacyclin (PGI2) and Thromboxane A2 (TXA2) Biosynthesis as a New Aspect of their Mode of Action

  • Chapter
Cardiology
  • 73 Accesses

Abstract

The discovery of TXA2 and PGI2 with their antagonistic actions on vessel wall and platelets were unquestionably milestones that fundamentally altered the prevailing ideas on pathophysiology and therapy of cardiovascular diseases.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. S. J. Coker, J. M. Ledingham, J. R. Parratt, and I. J. Zeitlin, Aspirin inhibits both the early myocardial release of thromboxane B2 and ventricular ectopic activity following coronary artery occlusion in dogs, Scot.Med.J. 26: 169 (1981).

    Google Scholar 

  2. M. Tada, T. Kuzuya, M. Inoue, K. Kodama, M. Mishima, M. Yamada, M. Inui, and H. Abe, Elevation of thromboxane B2 levels in patients with classic and variant angina pectoris, Circulation 64: 1107 (1981).

    Article  PubMed  CAS  Google Scholar 

  3. W. Förster, Ef f ect of various agents on prostaglandin biosynthesis and the antiaggregatory effect, Acta Med.Scand. (Suppl.)642:35 (1980).

    Google Scholar 

  4. P. Mentz, K. Pönicke, H. U. Block, Ch. Gießler, K. -E. Blass, B. -L. Bayer, and W. Förster, Stimulierung der prostazyklinbiosynthese als möglicher wirkungsmechanismus van dipyridamol, Arzneim.-Forsch. 31:2075 (1981).

    CAS  Google Scholar 

  5. W. Förster, Influence of cardiovascular drugs on platelet aggregation, Adv.in Myocardiol. (in press).

    Google Scholar 

  6. H. -U. Block, W. Förster, and I. Heinroth, SIN-1, the main metabolite of molsidomine inhibits prostaglandin endoperoxide analogue — and arachidonic acid-induced platelet aggregation as well as platelet thromboxane A2 formation, Arzneim.-Forsch. 32; 189 (1982).

    CAS  Google Scholar 

  7. W. Sziegoleit, J. Rausch, M. György, E. Dekov, and M. Békés, Influence of acetylsalicylic acid on acute circulatory effects of pindolol in hypertensive patients, in: “Prostaglandins and Thromboxanes,” W. Förster, ed., Pergamon Press, (1981).

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1984 Springer Science+Business Media New York

About this chapter

Cite this chapter

Förster, W. (1984). Effects of Beta Receptor Blocking Drugs on Prostacyclin (PGI2) and Thromboxane A2 (TXA2) Biosynthesis as a New Aspect of their Mode of Action. In: Chazov, E.I., Smirnov, V.N., Oganov, R.G. (eds) Cardiology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-1824-9_37

Download citation

  • DOI: https://doi.org/10.1007/978-1-4757-1824-9_37

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4757-1826-3

  • Online ISBN: 978-1-4757-1824-9

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics