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Organometallic Reagents

  • Francis A. Carey
  • Richard J. Sundberg
Part of the Advanced Organic Chemistry book series

Abstract

The use of organometallic reagents in organic synthesis had its beginning around 1900 with the work of Victor Grignard, who discovered that alkyl and aryl halides reacted with magnesium metal to give homogeneous solutions. These “Grignard reagents” proved to be reactive carbon nucleophiles and have remained very useful synthetic reagents since that time. Organolithium reagents came into synthetic use somewhat later. In the last 20 years the number of useful synthetic reactions involving metal ions and organometallic compounds has expanded enormously. Certain of the transition metals, such as copper, palladium, and nickel, have gained important places in synthetic methodology. In addition to providing reagents for organic synthesis, the systematic study of the reaction of organic compounds with metal ions has created a large number of organometallic compounds, many with unique structures and reactivity. We shall consider here first the reagents such as the Grignard reagents and organolithium compounds. The role of transition metals in organic synthesis will then be given attention. The final section of the chapter illustrates briefly a few typical organometallic compounds.

Keywords

Organometallic Compound Aryl Halide Grignard Reagent Conjugate Addition Organic Derivative 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1983

Authors and Affiliations

  • Francis A. Carey
    • 1
  • Richard J. Sundberg
    • 1
  1. 1.University of VirginiaCharlottesvilleUSA

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