Use of Cholesteryl Ester Analogs to Study Transport of Lipoproteins in Intact Animals
Deposition of lipid is one of the major events in the development of atheroma and therefore any attempt to study regression of atheroma faces the problem of quantitation of the lipids present at the various stages of regression. During the past few years we have synthesized labeled analogs of cholesteryl ester (1) and triacylglycerol (2,3) which owing to the replacement of the ester bond by an ether bond are not hydrolyzed by the esterases present in animal tissues. These compounds have been studied in several different systems in vivo and in vitro (3–9) and the data obtained indicate that they can serve as stable markers for the estimation of cholesterol ester deposited in the aortic wall.
KeywordsCholesteryl Ester Cholesteryl Ester Transfer Protein Glyceryl Ether Hypercholesterolemic Rabbit Glycerol Ether
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