Studies on Arterial Interstitial Fluid

  • Elspeth B. Smith


Change in the environment of arterial smooth muscle cells, and particularly in the concentration of low-density lipoprotein (LDL), is assumed to be a major factor in atherogenesis, and to be mediated through changes in the permeability of the arterial endothelium. The immediate nutrient environment of the cells in most tissues is provided by the interstitial fluid, and there is evidence that the composition of the interstitial fluid, at least in limbs, is similar to the composition of lymph obtained from the same anatomical area.1 Analyses of plasma protein concentrations in lymph from several organs and tissues have now been published, and although there is some variation in overall protein concentration, all show an inverse relationship between concentration, expressed as percentage of plasma concentration, and relative molecular mass (Mr) or molecular diameter.1–5


Atherosclerotic Lesion Interstitial Fluid Cholesterol Ester Arterial Smooth Muscle Cell Human Aorta 


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Copyright information

© Springer Science+Business Media New York 1984

Authors and Affiliations

  • Elspeth B. Smith
    • 1
  1. 1.Department of Chemical PathologyUniversity of AberdeenForesterhill, AberdeenScotland, UK

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