High-Density Lipoproteins and Their Role in Preventing or Retarding Atherosclerosis
Among the primary risk factors of coronary heart disease (CHD), hypercholesterolemia, hypertension, and nicotine abuse take highest precedence. A total cholesterol level > 300 mg/dl signifies a high atherogenic risk for the person in question. However, hypercholesterolemia (> 300 mg/dl) is observed in only approximately 25% of all patients with CHD. The majority of CHD patients exhibit a total cholesterol level between 248 and 300 mg/dl. In correspondence with the results of the Framingham study, the distribution curve for total serum cholesterol in probands in whom CHD develops overlaps considerably with that in probands who exhibit no CHD; the average cholesterol value of probands suffering from CHD is 225 mg/dl (219 mg/dl in probands in whom CHD does not develop).1 With these results as a basis, it is not possible, in an individual case involving a total cholesterol level between 150 and 300 mg/dl, to make a statement regarding coronary risk.
KeywordsCholesterol Obesity Hydrolysis Hepatitis Lipase
Unable to display preview. Download preview PDF.
- 2.G. Assmann, “Lipid Metabolism and Atherosclerosis,” Schattauer-Verlag, Stuttgart (1982).Google Scholar
- 3.G. Assmann, H. Schriewer, and K. H. Juchem, Zur Rolle des HDL-Cholesterins in der Präventivmedizin, Therapiewoch 31: 5563 (1981).Google Scholar
- 4.R. W. Mahley, Alterations in plasma lipoproteins induced by cholesterol feeding in animals including man, in: “Disturbances in Lipid and Lipoprotein Metabolism,” J. M. Dietschy, A. M. Gotto Jr., and J, A. Ontko, eds., American Physiological Society, Bethesda (USA) (1978).Google Scholar
- 7.E. J. Schaefer and R. I. Levy, Composition and metabolism of high density lipoproteins, Prog. Biochem. Pharmacol. 15: 200 (1979).Google Scholar
- 8.E. J. Schaefer, S. Eisenberg, and R. I. Levy. Lipoprotein apoprotein metabolism, J. Lipid Res. 19: 667 (1978).Google Scholar
- 15.G. Assmann, H. Funke, and H. Schriewer, The relationship of HDL-apolipoprotein A-I and HDL-cholesterol to risk factors of coronary heart disease. Initial results of the prospective epidemiological study in company employees in Westfalia, J. Clin. Chem. Clin. Biochem. 20: 287 (1982).Google Scholar
- 16.G. M. Kostner, P. Avogaro, G. Bittolo-Bon, G. Cazzalato, and G. B. Quinci, Determination of high-density lipoproteins: screening methods compared, Clin. Chem. 25: 939 (1979).Google Scholar
- 21.R. G. Kladetzky, G. Assmann, S. Walgenbach, P. Tauchert, and H.-D. Helb, Lipid and apoprotein values in coronary angiography patients, Artery 7: 191 (1980).Google Scholar
- 23.N. E. Miller, HDL-cholesterol, tissue cholesterol and coronary atherosclerosis. Epidemiological correlations, in “Atherosclerosis V: Proceedings of the 5th International Symposium,” A. M. Gotto Jr., L. C. Smith, and B. Allen, eds., Springer, New York (1980).Google Scholar
- 25.H. Schriewer, H. Schulte, and G. Assmann, HDL phosphatidyl choline and risk factors of coronary heart disease. Prospective epidemiological study of company employees of Westfalia, (manuscript submitted).Google Scholar