Advertisement

Sex Cord-Stromal Tumors

  • Robert E. Scully

Abstract

This category of ovarian neoplasms includes all those that contain granulosa cells, theca cells and their luteinized derivatives, Sertoli cells, Leydig cells, and fibroblasts of gonadal stromal origin, singly or in various combinations and in varying degrees of differentiation. The generic terms that have been most widely applied to these tumors reflect differing views of gonadal embryology. Those investigators who are convinced that all the cell types listed above, including granulosa and Sertoli cells, are derived from the mesenchyme or “specialized stroma” of the genital ridge have proposed the terms mesenchymomas3 and gonadal stromal tumors for these neoplasms.25,26

Keywords

Granulosa Cell Sertoli Cell Leydig Cell Theca Cell Granulosa Cell Tumor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Berlin NI, Van Scott EJ, Clendenning WE, Archard HO, Block JB, Witkop CJ, and Haynes HA (1966). Basal cell nevus syndrome. Ann Intern Med 64: 403PubMedCrossRefGoogle Scholar
  2. 2.
    Burslem RW, Langley FA, Woodcock AS (1954) A clinicopathological study of oestrogenic ovarian tumours. Cancer 7: 552CrossRefGoogle Scholar
  3. 3.
    Busby T, Anderson GW (1954) Feminizing mesenchymomas of the ovary. Am J Obstet Gynecol 68: 1391PubMedGoogle Scholar
  4. 4.
    Case Records of the Massachusetts General Hospital. (1971) Case 24, 1971. N Engl J Med 284: 1369CrossRefGoogle Scholar
  5. 5.
    Chalvardjian A, Scully RE (1973) Sclerosing stromal tumors of the ovary. Cancer 31: 664PubMedCrossRefGoogle Scholar
  6. 6.
    Dickersin GR, Scully RE Personal observationsGoogle Scholar
  7. 7.
    Dockerty MB, MacCarty WC (1939) Granulosa cell tumors; with the report of a 34-lb. specimen and a review. Am J Obstet Gynecol 37: 425Google Scholar
  8. 8.
    Evans AT, Gaffey TA, Malkasian GD Jr, Annegers JF (1980) Clinicopathologic review of 118 granulosa and 82 theca cell tumors. Obstet Gynecol 55: 231PubMedGoogle Scholar
  9. 9.
    Fathalla MF (1967) The occurrence of granulosa and theca tumors in clinically normal ovaries. A study of 25 cases. J Obstet Gynaecol Br Commonw 74: 279CrossRefGoogle Scholar
  10. 10.
    Fathalla MF (1968) The role of the ovarian stroma in hormone production by ovarian tumors. J Obstet Gynaecol Br Commonw 75: 78PubMedCrossRefGoogle Scholar
  11. 11.
    Fox H, Agrawal K, Langley FA (1975) A clinicopa-thologic study of 92 cases of granulosa cell tumor of the ovary with special reference to the factors influencing prognosis. Cancer 35: 231PubMedCrossRefGoogle Scholar
  12. 12.
    Gusberg SB, Kardon P (1971) Proliferative endometrial response to theca-granulosa cell tumors. Am J Obstet Gynecol 111: 633PubMedGoogle Scholar
  13. 13.
    Iturzaeta N, Kenny FM, Sieber W (1967) Precocious pseudopuberty due to granulosa cell tumor in three girls. Am J Dis Child 114: 39Google Scholar
  14. 14.
    Johnston WW, Goldston WR, Montgomery MS (1971) Clinicopathologic studies in feminizing tumors of the ovary. III. The role of genital cytology. Acta Cytol 15: 334PubMedGoogle Scholar
  15. 15.
    Jolly H (1955) Sexual Precocity. A Personal Study of 69 Patients. American Lecture Series, Springfield, Ill., Charles C ThomasGoogle Scholar
  16. 16.
    Judd HL, Spore WW, Talner LB, Rigg LA, Yen SSC, Benirschke K (1974) Preoperative localization of a testosterone-secreting ovarian tumor by retrograde venous catherization and selective sampling. Am J Obstet Gynecol 120: 91PubMedGoogle Scholar
  17. 17.
    Kalstone CE, Jaffe RB, Abell MR (1969) Massive edema of the ovary simulating fibroma. Obstet Gynecol 34: 564PubMedGoogle Scholar
  18. 18.
    Kottmeier HL (1953) Carcinoma of the Female Genitalia. The Abraham Flexner Lectures, Series No. 11, Baltimore, Williams and WilkinsGoogle Scholar
  19. 19.
    Malkasian GD Jr, Webb MJ, Jorgensen EO (1974) Observations on chemotherapy of granulosa cell carcinomas and malignant ovarian teratomas. Obstet Gynecol 44: 885PubMedGoogle Scholar
  20. 20.
    Meigs JV (1954) Fibroma of the ovary with ascites and hydrothorax. Meigs’ syndrome. Am J Obstet Gynecol 67: 962PubMedGoogle Scholar
  21. 21.
    Morris JMcL, Scully RE (1958) Endocrine Pathology of the Ovary. St. Louis, C. V. Mosby Co.Google Scholar
  22. 22.
    Morrison CW, Woodruff JD (1964) Fibrothecoma and associated ovarian stromal neoplasia. Obstet Gynecol 23: 344PubMedGoogle Scholar
  23. 23.
    Mostofi FK, Price EB Jr (1973) Tumors of the male genital system. Atlas of Tumor Pathology, Second Series, Fascicle 8. Washington, D.C., Armed Forces Institute of PathologyGoogle Scholar
  24. 24.
    Niswander KR, Courey NG, Woodward T (1965) Precocious pseudopuberty caused by ovarian tumors. Obstet Gynecol 26:381PubMedGoogle Scholar
  25. 25.
    Norris HJ, Chorlton (1974) I Functioning tumors of the ovary. Clin Obstet Gynecol 17: 189CrossRefGoogle Scholar
  26. 26.
    Norris HJ, Taylor HB (1968) Prognosis of granu-losa-theca tumors of the ovary. Cancer 21: 255PubMedCrossRefGoogle Scholar
  27. 27.
    Norris HJ, Taylor HB (1969) Virilization associated with cystic granulosa tumors. Obstet Gynecol 34: 629PubMedGoogle Scholar
  28. 28.
    Novak ER, Kutchmeshgi J, Mupas RS, Woodruff JD, et al. (1971) Feminizing gonadal stromal tumors. Obstet Gynecol 38: 701PubMedGoogle Scholar
  29. 29.
    Novak ER, Long JH (1965) Arrhenoblastoma of the ovary. Am J Obstet Gynecol 92: 1082PubMedGoogle Scholar
  30. 30.
    O’Hern TM, Neubecker RD (1962) Arrhenoblastoma. Obstet Gynecol 19: 758PubMedGoogle Scholar
  31. 31.
    Osborn RH, Yannone ME (1971) Plasma androgens in the normal and androgenic female: A review. Obstet Gynecol Surv 26: 195CrossRefGoogle Scholar
  32. 32.
    Prunty FTG (1967) Hirsutism, virilism and apparent virilism and their gonadal relationship. Part 1. J Endocrinol 38: 85PubMedCrossRefGoogle Scholar
  33. 33.
    Roth LM, Sternberg WH (1973) Ovarian stromal tumors containing Leydig cells. II. Pure Leydig cell tumor, non-hilar type. Cancer 32: 952PubMedCrossRefGoogle Scholar
  34. 34.
    Samanth KK, Black WC (1970) Benign ovarian stromal tumors associated with free peritoneal fluid. Am J Obstet Gynecol 107: 538PubMedGoogle Scholar
  35. 35.
    Scully RE (1962) Androgenic lesions of the ovary. In: The Ovary, Grady HG, Smith DE (eds). International Academy of Pathology Monograph No. 3, Baltimore, Williams and Wilkins, pp 143–174Google Scholar
  36. 36.
    Scully RE (1964) Stromal luteoma of the ovary. A distinctive type of lipoid-cell tumor. Cancer 17: 769PubMedCrossRefGoogle Scholar
  37. 37.
    Scully RE (1968) Sex cord-mesenchyme tumours. Pathologic classification and its relation to prognosis and treatment. In: Ovarian Cancer, Junqueira, AC, Gentil F (eds) IUCC Monograph Series, Vol. II. Heidelberg, Springer-Verlag, pp 40–56Google Scholar
  38. 38.
    Scully RE (1970) Sex cord tumor with annular tubules. A distinctive ovarian tumor of the Peutz-Jeghers syndrome. Cancer 25: 1107PubMedCrossRefGoogle Scholar
  39. 39.
    Scully RE (1970) Gonadoblastoma. A review of 74 cases. Cancer 25: 1340PubMedCrossRefGoogle Scholar
  40. 40.
    Serment HL, Laffargue P, Piana L, Blanc B (1970) Ovarian hormone tumors of female children. Int J Gynaecol Obstet 8: 409Google Scholar
  41. 41.
    Serov SF, Scully RE, Sobin LH (1973) International Histological Classification of Tumours, No. 9. Histological Typing of Ovarian Tumours. Geneva, World Health OrganizationGoogle Scholar
  42. 42.
    Sjostedt S, Wahlen T (1961) Prognosis of granulosa cell tumors. Acta Obstet Gynecol Scand 40: 1Google Scholar
  43. 43.
    Smith JP, Rutledge F (1970) Chemotherapy in the treatment of cancer of the ovary. Am J Obstet Gynecol 107: 691PubMedGoogle Scholar
  44. 44.
    Sotto LSJ, Postoloff AV, Carr F (1956) A case of calcified ovarian fibroma with ossification. Am J Obstet Gynecol 71: 1355PubMedGoogle Scholar
  45. 45.
    Stenwig JT, Hazekamp JT, Beecham JB (1979) Granulosa cell tumors of the ovary. A clinicopathological study of 118 cases with long-term follow-up. Gynec Oncol 7: 136CrossRefGoogle Scholar
  46. 46.
    Sternberg WH (1949) The morphology, endocrine function, hyperplasia and tumors of the human ovarian hilus cells. Am J Pathol 25: 493PubMedGoogle Scholar
  47. 47.
    Sternberg WH, Roth LM (1973) Ovarian stromal tumors containing Leydig cells. 1. Stromal-Leydig cell tumor and non-neoplastic transformation of ovarian stoma to Leydig cells. Cancer 32: 940PubMedCrossRefGoogle Scholar
  48. 48.
    Targett CS (1974) Estrogen excretion in a case of theca-granulosa cell tumor. Am J Obstet Gynecol 119: 859PubMedGoogle Scholar
  49. 49.
    Taylor HB, Norris HJ (1967) Lipid cell tumors of the ovary. Cancer 20: 1953PubMedCrossRefGoogle Scholar
  50. 50.
    Teilum G (1958) Classification of testicular and ovarian androblastoma and Sertoli cell tumors. Cancer 11: 769PubMedCrossRefGoogle Scholar
  51. 51.
    Teilum G (1971) Special Tumors of Ovary and Testis. Comparative Pathology and Histological Identification. Philadelphia, LippincottGoogle Scholar
  52. 52.
    Waxman M, Vuletin JC, Urcuyo R, Belling CG (1979) Ovarian low-grade stromal sarcoma with thecoma-tous features. A critical reappraisal of the so-called “malignant thecoma.” Cancer 44: 2206PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1982

Authors and Affiliations

  • Robert E. Scully

There are no affiliations available

Personalised recommendations