T4 Bacteriophage as a Model Genetic System

  • Edward A. Birge
Part of the Springer Series in Microbiology book series (SSMIC)


This chapter, in combination with Chapters 5 and 6, will present an overview of some of the most extensively studied bacteriophages. The intent of all three chapters is to illustrate the basic nature of genetic processes using some of the simplest genetic systems as examples. In Chapter 1, the distinction was made between phages which are always virulent and those which can temper their lytic response to form lysogens. Chapters 4 and 5 will discuss the intemperate (i.e., virulent) phages, while Chapter 6 will discuss the problems associated with lysogeny. The details concerning regulation of the kinds of metabolic activities discussed in these chapters will be deferred until Chapter 12.


Phage Particle Phage Infection Tail Fiber Hydroxymethyl Cytosine Eclipse Phase 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.



  1. Doermann, A.H. 1953. The vegetative state in the life cycle of bacteriophage: evidence for its occurrence, and its genetic characterization. Cold Spring Harbor Symposia on Quantitative Biology 18:3–11.PubMedCrossRefGoogle Scholar
  2. Mathews, C.K. 1977. Reproduction of large virulent bacteriophages, pp. 179–294. In: Fraenkel-Conrat, H., Wagner, R.R. (eds.) Comprehensive Virology, vol. 7. New York: Plenum Press.CrossRefGoogle Scholar
  3. Rabussay, D., Geiduschek, E.P. 1977. Regulation of gene action in the development of lytic bacteriophages, pp. 1–196. In: Fraenkel-Conrat, H., Wagner, R.R. (eds.) Comprehensive Virology, vol. 8. New York: Plenum Press.Google Scholar
  4. Wood, W.B., Revel, H.R. 1976. The genome of bacteriophage T4. Bacteriological Reviews 40:847–868.PubMedGoogle Scholar
  5. Wu, R., Geiduschek, E.P., Rabussay, D., Cascino, A. 1973. Regulation of transcription in bacteriophage T4-infected E. coli—A brief review and some recent results, pp. 181–204. In: Fox, C.F., Robinson, W.S. (eds.) Virus Research. New York: Academic Press.Google Scholar


  1. Benzer, S. 1961. On the topography of the genetic fine structure. Proceedings of the National Academy of Sciences of the United States of America 47:403–415.PubMedCrossRefGoogle Scholar
  2. David, M., Vekstein, R., Kaufmann, G. 1979. RNA ligase reaction products in plasmolyzed E. coli cells infected by T4 bacteriophage. Proceedings of the National Academy of Sciences of the United States of America 76:5430–5434.PubMedCrossRefGoogle Scholar
  3. Ellis, E.L., Delbrück, M. 1939. The growth of bacteriophage. Journal of General Physiology 22:365–384.PubMedCrossRefGoogle Scholar
  4. Huberman, J.A. 1968. Visualization of replicating mammalian and T4 bacteriophage DNA. Cold Spring Harbor Symposia on Quantitative Biology 33:509–524.PubMedCrossRefGoogle Scholar
  5. Kao, S.-H., McClain, W.H. 1980. Baseplate protein of bacteriophage T4 with both structural and lytic functions. Journal of Virology 34:95–103.PubMedGoogle Scholar
  6. Kozloff, L.M., Crosby, L.K., Baugh, C.M. 1979. Structural role of the polyglutamate portion of the folate found in T4D bacteriophage baseplate. Journal of Virology 32:497–506.PubMedGoogle Scholar
  7. Linder, C.H., Sköld, O. 1980. Control of early gene expression of bacteriophage T4: involvement of the host rho factor and the mot gene of the bacteriophage. Journal of Virology 33:724–732.PubMedGoogle Scholar
  8. Murialdo, H., Becker, A. 1978. Head morphogenesis of complex double-stranded deoxyribonucleic acid bacteriophages. Microbiological Reviews 42:529–576.PubMedGoogle Scholar
  9. Rabussay, D., Geiduschek, E.P. 1979. Relation between bacteriophage T4 DNA replication and late transcription in vitro and in vivo. Virology 99:286–301.PubMedCrossRefGoogle Scholar
  10. Séchaud, J., Streisinger, G., Emrich, J., Newton, J., Lanford, H., Reinhold, H., Stahl, M.M. 1965. Chromosome structure in phage T4. II. Terminal redundancy and heterozygosis. Proceedings of the National Academy of Sciences of the United States of America 54:1333–1339.PubMedCrossRefGoogle Scholar
  11. Steven, A.C., Carrascosa, J.L. 1979. Proteolytic cleavage and structural transformation: their relationship in bacteriophage T4 capsid maturation. Journal of Supramolecular Structure 10:1–11.PubMedCrossRefGoogle Scholar
  12. Visconti, N., Delbrück, M. 1953. The mechanism of genetic recombination in phage. Genetics 38:5–33.PubMedGoogle Scholar
  13. Wood, W.B., King, J. 1979. Genetic control of complex bacteriophage assembly, pp. 581–635. In: Fraenkel-Conrat, H., Wagner, R.R. (eds.) Comprehensive Virology vol. 13. New York: Plenum Press.Google Scholar

Copyright information

© Springer Science+Business Media New York 1981

Authors and Affiliations

  • Edward A. Birge
    • 1
  1. 1.Department of Botany and MicrobiologyArizona State UniversityTempeUSA

Personalised recommendations