A New Approach for Clinical Study of Control of Respiration
Most acute and chronic lung diseases are accompanied by hyperventilation, usually in the form of rapid, shallow breathing. This pattern occurs in patients with acute pulmonary vascular congestion and edema, and has been linked with increased J-receptors discharge.1,2 However, CO2 retention in acute pulmonary edema is not uncommon. The reasons why some patients with edema develop CO2 retention are not clear. Arterial PCO2 was found not to be correlated with roentgenographic abnormality, PaO2, or survival.3 Further, CO2 retention was not related to the ventilatory response to CO2 measured after the edema had resolved.4 In chronic pulmonary congestion due to mitral stenosis resting ventilation is high and PaCO2 low, while the ventilatory response to CO2 is lower than normal.5 After corrective surgery, resting ventilation in two patients with mitral stenosis decreased and the ventilatory response to CO2 increased.5 It is not known whether lung function tests improved following surgery.
KeywordsResidual Volume Mitral Stenosis Ventilatory Response Total Lung Capacity Inspiratory Flow
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- 1.A. Guz, M.I.M. Noble, J.H. Eisele, and D. Trenchard, Experimental results of vagal block in cardiopulmonary disease, in: “Breathing: Hering Breuer Centenary Symposium,” Ciba Foundation, J. & A. Churchill, London (1970).Google Scholar
- 2.A. S. Paintal, The mechanism of excitation of type J receptors, and the J reflex, in: “Breathing: Hering-Breuer Centenary Symposium,” Ciba Foundation, J. & A. Churchill, London (1970).Google Scholar
- 4.M. Spierer,The ventilatory response to carbon dioxide in patients who have recovered from cardiogenic pulmonary edema, Clin. Sci. Molec. Med. 47: 285 (1974).Google Scholar
- 6.D.J.C. Read, A. Clinical method for assessing the ventilatory response to carbon dioxide, Australas Ann. Med. 16: 20 (1967).Google Scholar
- 9.J. Milic-Emili, and J.M. Tyler, Relation between work output of respiratory muscles and end-tidal CO2 tension, J. Appl. Physiol. 18: 497 (1963).Google Scholar
- 13.J. Šorli, A. Grassino, G. Lorange, and J. Milic-Emili, Control of breathing in patients with chronic obstructive lung disease, Clin. Sci. Molec. Med. 54: 295 (1978).Google Scholar
- 14.J.-Ph. Derenne, M. Aubier, D. Murciano, M. Fournier, and R. Pariente, Hypoxic contribution to central respiratory drive in acute and chronic respiratory failure, Bull. Eur. Physiopath. Resp. 13: 130 (1977).Google Scholar