The Nature of Zone 4 in Regional Distribution of Pulmonary Blood Flow

  • J. Milic-Emili
  • N. M. Siafakas
Part of the Ettore Majorana International Science Series book series (EMISS, volume 3)


The first measurements of the regional distribution of pulmonary blood flow in man were made using O2-labelled carbon dioxide.1 The results in 16 normal upright subjects are shown in Fig.1. The clearance rates were measured during 10–15 seconds breath-holding following an inspiration of one liter of radioactive carbon dioxide from functional residual capacity. If we take the clearance rate of O2-labelled carbon dioxide as a measure of blood flow per unit lung volume,2 Fig.l shows that blood flow increased more or less steadily from the top to the bottom of the upright lung, with very low values at the apex. This general pattern was confirmed by early results with Xenon-133.3,4 A discrepancy, however, was found between these results and those obtained by West et al5 on an isolated dog lung preparation.


Pulmonary Hypertension Lung Volume Regional Distribution Residual Volume Pulmonary Blood Flow 
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  1. 1.
    J.B. West and C.T. Dollery, Distribution of blood flow and ventilation-perfusion ratio in the lung, measured with radioactive CO2, J. Appl. Physiol. 15: 405 (1960).PubMedGoogle Scholar
  2. 2.
    J.B. West(Ed), Regional differences in the lung. Academic Press, New York, San Francisco, London, 1977.Google Scholar
  3. 3.
    W.C. Ball, Jr., P.B. Stewart, L.G.S. Newsham, and D.V. Bates, Regional pulmonary function studied with Xenon 133, J. Clin. Invest. 41: 519 (1962).CrossRefPubMedGoogle Scholar
  4. 4.
    A.C. Bryan, L.G. Bentivoglio, F. Beerel, H. MacLeish, A. Zidulka, and D.V. Bates, Factors affecting regional distribution of ventilation and perfusion in the lung, J. Appl. Physiol. 19: 395 (1964).PubMedGoogle Scholar
  5. 5.
    J.B. West, C.T. Dollery, and A. Naimark, Distribution of blood flow in isolated lung; relation to vascular and alveolar pressure, J. Appl. Physiol. 19: 713 (1964).PubMedGoogle Scholar
  6. 6.
    S. Permutt, B. Bromberger-Barnea and H.N. Bane, Alveolar pressure, pulmonary venous pressure, and the vascular waterfall, Med. Thorac. 19: 239 (1962).PubMedGoogle Scholar
  7. 7.
    J. Milic-Emili, J.A.M. Henderson, M.B. Dolovich, D. Trop, and K. Kaneko, Regional distribution of inspired gas in the lung, J. Appl. Physiol. 21: 749 (1966).PubMedGoogle Scholar
  8. 8.
    N. R. Anthonisen, and J. Milic-Emili, Distribution of pulmonary perfusion in erect man, J. Appl. Physiol. 21: 760 (1966).PubMedGoogle Scholar
  9. 9.
    J. Butler, and H.W. Paley, Lung volume and pulmonary circulation. The effect of sustained changes in lung volume on pressure-flow relationships in the human pulmonary circulation, Med. Thorac. 19: 261 (1962).PubMedGoogle Scholar
  10. 10.
    J.M.B. Hughes, J.B. Glazier, J.E. Maloney, and J.B. West, Effect of lung volume on the distribution of pulmonary blood flow in man, Resp. Physiol. 4: 58 (1968).CrossRefGoogle Scholar
  11. 11.
    M. Arborelius, Jr., and B. Lilja, Haemodynamic changes at different lung volumes. Scand. J. Clin. Lab. Invest. 29: 359 (1972).CrossRefPubMedGoogle Scholar
  12. 12.
    J. Milic-Emili, and F. Ruf, Effect of expiratory flow rate on closing capacity. In: Distribution of Pulmonary Gas Exchange, INSERM, 22–24, Sept. 1975, Vol. 51, pp.395–396.Google Scholar

Copyright information

© Springer Science+Business Media New York 1980

Authors and Affiliations

  • J. Milic-Emili
    • 1
  • N. M. Siafakas
    • 1
  1. 1.Department of PhysiologyMcGill UniversityMontrealCanada

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