Vaccination-Immunoprophylaxis in Coccidioidomycosis
Rixford and Gilchrist, in their original studies at the turn of the century, showed that experimentally infected animals were more resistant to superinfection.1 A half century then elapsed before serious experimentation was conducted on the subject of the effect of vaccination. Negroni reported such studies with nonviable organisms,2 and Smith with attenuated live organisms.3 Levine, Kong, Savage and other workers at the Naval Biosciences Laboratory, and others, in the decade of the 1960s performed extensive studies which defined our present directions and concepts regarding vaccination. Much of the history of the immunoprophylactic approach to coccidioidomycosis is outlined in Chapter 1.
KeywordsMaximal Tolerable Dose Intramuscular Dose Early Inflammatory Response Intravenous Vaccination Johns Hopkins Hosp
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