Glomerulonephritis: Pathogenesis and Classification
Glomerulonephritis is defined as a clinicopathological condition which characteristically involves both kidneys or only one kidney when the other kidney is congenitally absent or has been removed due to trauma, tumor, or abscess. It is characterized by the deposition of immunoglobulins (or antibody) in the glomeruli, sometimes in the tubules, and, rarely, in the interstitium and arterioles. These immunoglobulins are observed as deposits by electron and immunofluorescence microscopy. Frequently, neutrophilic leukocytes and complement components are also identified in the lesions. Other forms of glomerulonephritis, in which immunoglobulin and complement deposition are absent, also occur.
KeywordsImmune Complex Lupus Nephritis Immunofluorescence Microscopy Glomerular Basement Membrane Crescentic Glomerulonephritis
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