Glomerulonephritis: Pathogenesis and Classification

  • Anil K. Mandal


Glomerulonephritis is defined as a clinicopathological condition which characteristically involves both kidneys or only one kidney when the other kidney is congenitally absent or has been removed due to trauma, tumor, or abscess. It is characterized by the deposition of immunoglobulins (or antibody) in the glomeruli, sometimes in the tubules, and, rarely, in the interstitium and arterioles. These immunoglobulins are observed as deposits by electron and immunofluorescence microscopy. Frequently, neutrophilic leukocytes and complement components are also identified in the lesions. Other forms of glomerulonephritis, in which immunoglobulin and complement deposition are absent, also occur.


Immune Complex Lupus Nephritis Immunofluorescence Microscopy Glomerular Basement Membrane Crescentic Glomerulonephritis 
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Copyright information

© Springer Science+Business Media New York 1979

Authors and Affiliations

  • Anil K. Mandal
    • 1
  1. 1.Renal Electron Microscopy Laboratory and Staff Physician, Medical Service Veterans Administration HospitalUniversity of Oklahoma College of MedicineOklahoma CityUSA

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