Radiation-Induced Cross-Linking of DNA and Protein in Bacteria

  • Kendric C. Smith


The cross-linking of DNA and protein was the first in vivo photochemical hetero-addition reaction to be reported (Smith, 1962; Alexander and Moroson, 1962). It was observed that with increasing fluences of UV radiation, decreasing amounts of DNA free of protein could be extracted from the irradiated cells (Fig. 1). The DNA that was unextractable was found in the insoluble protein fraction (Smith, 1962).


Methylene Blue Acridine Orange Action Spectrum Sodium Lauryl Sulfate Photodynamic Action 
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Copyright information

© Springer Science+Business Media New York 1976

Authors and Affiliations

  • Kendric C. Smith
    • 1
  1. 1.Department of RadiologyStanford University School of MedicineStanfordUSA

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