Role of DNA Repair in Mutation and Cancer Production

  • James E. Trosko
  • Chia-Cheng Chang


The somatic mutation theory of carcinogenesis was postulated long before there was knowledge of the molecular structure of genetic material, the physical, chemical and/or biological nature of carcinogens, or the nature of the interaction between cellular DNA and the carcinogenic agents (Boveri, 1929). The concept was originally introduced to account for two of the many observations of neoplastic growth; (a) the unlimited variety of tumor types, and (b) the fact that, after cell division, the daughter cells maintain their neoplastic properties.


Excision Repair Chromosome Aberration Chemical Carcinogen Phorbol Myristate Acetate Xeroderma Pigmentosum 
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Copyright information

© Springer Science+Business Media New York 1976

Authors and Affiliations

  • James E. Trosko
    • 1
  • Chia-Cheng Chang
    • 1
  1. 1.Department of Human Development, College of Human MedicineMichigan State UniversityEast LansingUSA

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