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Addition of Amino Acids and Related Substances to Nucleic Acids by Nucleophilic Catalysis

  • Robert Shapiro

Abstract

Little attention has been paid to nucleophilic reactants when considering the biologically important transformations of nucleic acids. The role of free radical processes in the radiation chemistry and photochemistry of nucleic acids is well appreciated (Smith, 1975). In the case of chemical carcinogenesis, it has been suggested that the ultimate carcinogens are often, or perhaps always, strong electrophilic reagents (Miller, 1970; Heidelberger, This Volume). Nucleic acids, do, however, contain a number of sites susceptible to nucleophilic attack, and there is no obvious reason why alterations at these positions should be of less significance then changes produced at other locations by other mechanisms. In fact, nucleophilic reactions on nucleic acid are involved in a number of biologically important processes.

Keywords

Adduct Formation Sodium Bisulfite Nucleophilic Reagent Nucleophilic Catalysis Ultimate Carcinogen 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1976

Authors and Affiliations

  • Robert Shapiro
    • 1
  1. 1.Department of ChemistryNew York UniversityNew YorkUSA

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