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Helper Activity for the Defective Friend Leukemia Virus in Human Malignant Cell Cultures

  • Audrey Fjelde

Abstract

The search for a possible viral etiology for human malignancy is at the forefront of current cancer research. Faced with the difficulties present in human investigation, scientists have found it necessary to use indirect approaches. This area of cancer research is further complicated by the fact that the necessary information for malignancy may be present in a cell without demonstrable virus particles. The genetic constitution of the host is an important factor controlling the expression of malignancy, and it has been shown that an agent causing only a mild infection in human beings can cause a malignant lesion in other species (Trentin et al., 1962). A genetic basis for leukemogenesis has been described (Lilly et al., 1964; Odaka and Yamamoto, 1962).

Keywords

Leukemia Virus Helper Virus Helper Activity Friend Virus Reticulum Cell Sarcoma 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1975

Authors and Affiliations

  • Audrey Fjelde
    • 1
  1. 1.Roswell Park Memorial InstituteBuffaloUSA

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