Cell Lines from Humans with Hematopoietic Malignancies

  • George E. Moore


Temporary cultures of hematopoietic cells have been studied by cell biologists since 1913. Unfortunately, most cultures were eventually overgrown by fibroblasts. Several investigators claimed that they had established permanent hematopoietic cell lines, but, in retrospect, the data used to support such claims were unacceptable. Several epithelioid cell lines derived from bone marrow cultures probably represented malignant cells that had metastasized from primary carcinomas. Epstein and Barr (1964) and Pulvertaf t (1964) reported the successful culture of lymphoid cells from biopsies of Burkitt’s lymphoma. Shortly thereafter, Iwakata and Grace (1964) established a lymphoil cell line from the blood of a patient with chronic myelogenous leukemia. In July 1966, we (Moore et al., 1967) established lymphoid cell lines from the blood of two normal persons.


Lymphoid Cell Acute Leukemia Infectious Mononucleosis Bone Marrow Culture Hematopoietic Cell Line 
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Copyright information

© Springer Science+Business Media New York 1975

Authors and Affiliations

  • George E. Moore
    • 1
    • 2
  1. 1.Surgical OncologyDenver General HospitalDenverUSA
  2. 2.University of Colorado Medical CenterDenverUSA

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