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Principles and Methods in Receptor Binding pp 161–193Cite as

Steroid Hormone Receptors in Endocrine-Related Tumors

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Part of the book series: NATO ASI Series ((NSSA,volume 72))

Abstract

One of the main objectives in the fight against cancer is the identification of precise tumor markers which can aid in selecting the most appropriate treatment for each individual patient. This is particularly relevant with regard to tumors arising in hormone target tissues, such as breast, endometrium, ovary and prostate carcinoma or leukemia and lymphoma, which often retain the hormone sensitivity of their parent cells. Endocrine manipulations designed to modify endogenous hormone influences on some of these tumors preceeded any rational understanding of the mechanism of hormone action. The concept of steroid receptors was introduced into the scientific world for the first time about twenty years ago (Folca et al., 1961; Jensen and Jacobson, 1962). A great deal of work has been done in recent years on the mechanism of action of steroid hormones and relationships between the presence of receptors in endocrine-related tumors and both the responsiveness to therapy and the prognosis. However, it is now generally accepted that the mere presence of receptors in target cells is not sufficient to guarantee hormone responsiveness (Yamamoto and Alberts, 1976; Gehering, 1980; Lippman and Nawata, 1982).

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References

  1. Adams, J.B. and Wong, S.F., 1969, Desmolase activity of normal and malignant human breast tissue, J.Endocrinol., 44: 69.

    Article  PubMed  CAS  Google Scholar 

  2. Allegra, J.C., Barlock, A., Huff, K., and Lippman, M.E., 1980, Changes in multiple or sequential estrogen receptor determinations in breast cancer, Cancer, 45: 792.

    Article  PubMed  CAS  Google Scholar 

  3. A.M.A., American Medical Association Committee on Research, 1960, Androgens and estrogens in the treatment of disseminated mammary carcinoma, J.Amer.Med.Assoc., 172: 1271.

    Article  Google Scholar 

  4. Anderson, D.G., 1972, The possible mechanism of action of progestins on endometrial adenocarcinoma, Amer.J. Obstet.Gynec., 113: 195

    Google Scholar 

  5. Anderson, W.A., Kang, Y.H., and De Sombre, E.R., 1975, Endogenous peroxidase: a specific marker enzyme for tissue displaying growth dependency on estrogens, J.Cell.Biol., 64: 668.

    Article  PubMed  CAS  Google Scholar 

  6. Beatson, G.T., 1896, On the treatment of inoperable cases of carcinoma of the mamma. Suggestion for a new method of treatment with illustrative cases, Lancet, 11: 104

    Google Scholar 

  7. Bell, P.A., 1982, Glucocorticoids in the therapy of leukemia and lymphoma, in: “Clinics in Oncology. Hormone Therapy”, B.J.A. Furr, ed., W.B. Saunders Co.Ltd., London.

    Google Scholar 

  8. Bird, C.C., 1979, Clipical classification of leukemia and lymphoma in relation to glucocorticoid therapy, in: “Glucocorticoid action and leukemia”, P.A.Bell, N.M.Borthwick, eds., Alpha Omega Publ.Ltd., Cardiff.

    Google Scholar 

  9. Blamey, R.W., Bishop, H.M., Blake, J.R.S., Doyle, P.J., Elston, C.W., Haybittle, J.L., Nicholson, R.I., Griffiths, K., 1980, Relationship between primary breast tumor receptor status and patient survival, Cancer, 46: 2765.

    Article  PubMed  CAS  Google Scholar 

  10. Bloom, N.D., Tobin, E.H., and Schreibman, B., 1980, The role of progesterone receptor in the management of advanced breast cancer, Cancer, 45: 2992.

    Article  PubMed  CAS  Google Scholar 

  11. Bloomfield, C.D., Smith, K.A., Peterson, B.A., Hildebrandt, L., Zaleskas, J., Gajl-Peczalska, K.J., Frizzera, G., and Munck, A., 1980, In vitro glucocorticoid studies for predicting response to glucocorticoid therapy in adults with malignant lymphoma, Lancet, 1: 952.

    Article  PubMed  CAS  Google Scholar 

  12. Bloomfield, C.D., Kendall, A.S., Peterson, B.A., and Munk, A., 1981, Glucocorticoid receptors in adult acute Lymphoblastic leukemia. Cancer Res., 41: 4857.

    PubMed  CAS  Google Scholar 

  13. Bonadonna, G., Valagussa, P., Rossi, A., Tancini, G., Brambilla, C., Marchini, S., and Veronesi, U., 1981, Multimodal therapy with CMF in resectable breast cancer with positive axillary nodes.

    Google Scholar 

  14. The Milan Institute Experience, in: “Adjuvant therapy of cancer III”, S.E.Salmon and S.E.Jones, eds. Grune and Stratton Publ., New York.

    Google Scholar 

  15. Bonte, J., 1972, Medroxyprogesterone in the management of primary and recurrent metastatic adenocarcinoma, Acta Obstet.Gynec. Scand., 51 (Suppl.19): 21.

    Google Scholar 

  16. Bonte, J., 1980, Hormonal dependence of endometrial adenocarcinoma and its hormonal sensitivity to progestogens and antiestrogens, in: “Hormones and Cancer, ” S.Iacobelli, R.J.B.King, H.R. Lindner, and M.E.Lippman eds., Raven Press, New York.

    Google Scholar 

  17. Bonte, J., Decoster, J.M., Ide, P., and Billiet, G., 1978, Hormonoprophylaxis and hormonotherapy in the treatment of endometrial adenocarcinoma by means of medroxyprogesterone acetate. Gynec.Oncol., 6: 60.

    Article  CAS  Google Scholar 

  18. Bonte, J., Ide, P., Billiet, G., Wynants, P., 1981, Tamoxifen as a possible chemotherapeutic agent in endometrial adenocarcinoma, Gynec. Oncol., 11: 140.

    Google Scholar 

  19. Braunsberg, H., James, V.H.T., Jamieson, C.W., Desai, S., Carter, A.E., and Hulbert, M., 1974, Effect of age and menopausal status

    Google Scholar 

  20. on estimates of estrogen binding by human malignant breast tumours, Brit.Med.J., 791–745.

    Google Scholar 

  21. Broens, J., Mouridsen, M.T., and Soerensen, H.M., 1980, Tamoxifen in advanced endometrial carcinoma, Cancer Chemother.Pharmacol., 4: 213.

    Article  PubMed  CAS  Google Scholar 

  22. Brooks, S.C., Saunders, D.E., Singhakowinta, A., and Vaitkevicius, V.K., 1980, Relation of tumor content of estrogen and progesterone receptors with response of patient to endocrine therapy, Cancer, 46: 2775.

    Article  PubMed  CAS  Google Scholar 

  23. Bruckner, H.W. and DEPPE, G., 1977, Combination chemotherapy of advanced endometrial adenocarcinoma with adriamycin, cyclophosphamide, 5-fluorouracil, and medroxyprogesterone acetate, Obstet. Gynec., 50: 105.

    Google Scholar 

  24. Carbone, P.P., and Carter, S.K., 1974, Approach to development of effective chemotherapy, Gynec.Oncol., 2: 348.

    Article  CAS  Google Scholar 

  25. Chamness, G.C., and McGuire W.L., 1975, Scatchard plots: common errors in correction and interpretation, Steroids, 26: 538.

    Article  PubMed  CAS  Google Scholar 

  26. Chamness, G.C;, and McGuire, W.L., 1979, Methods for analysing steroid receptors in human breast cancer, in: “Breast Cancer 3. Advances in Research and Treatment, ” W.L.McGuire ed., Plenum Press, New York.

    Google Scholar 

  27. Cidlowski, J.A., and Michaels, G.A., 1977, Alteration in glucocorticoid binding site number during the cell cycle in the HeLa cells, Nature, 266: 643.

    Article  PubMed  CAS  Google Scholar 

  28. Claman, N.H., 1972, Corticosteroids and Lymphoid cells, New Engl. J.Med., 287: 388

    Google Scholar 

  29. Clark J.H., and Peck, E.J.Jr., 1979, Female sex steroids.Receptors and function. Monographs on Endocrinology, Springer Verlag, Berlin, Heidelberg, New York.

    Google Scholar 

  30. Cline, M.J., and Rosenbaum, E., 1980, Prediction of in vivo cytotoxicity of chemotherapeutic agents by their in vitro effect on leukocytes from patients with acute leukaemia, Cancer Res. 28: 2516.

    Google Scholar 

  31. Cohen, C.J., Deppe, G., and Bruckner, H.W., 1977, Treatment of advanced adenocarcinoma of the endometrium with melphalan, 5-STEROID HORMONE RECEPTORS IN ENDOCRINE-RELATED TUMORS 183 fluorouracil, and medroxyprogesterone acetate, Obstet.Gynecol., 50: 415.

    PubMed  CAS  Google Scholar 

  32. Cooper, A.P., 1835, Lectures on the principles and practice of surgery, John Thomas Cox, London

    Google Scholar 

  33. Crabtree, G.R., Smith, R.A., and Munck, A., 1978, Glucocorticoid receptors and sensitivity of isolated human leukemia and lymhoma cells, Cancer Res., 38: 4268.

    PubMed  CAS  Google Scholar 

  34. Crabtree, G.R., Bloomfield, C.D., Smith, K.A., McKenna, R.W., Peterson, B.A., Hildebrandt, L., and Munck, A., 1981, Glucocorticoid receptors and in vitro responses to glucocorticoid in acute non lymphocytic leukemia, Cancer Res., 41: 4853.

    PubMed  CAS  Google Scholar 

  35. Crocker, S.G3, Milton, P.J.D., and King, R.J.B., 1974, Uptake of (6, 7- H)oestradiol-17 by normal and abnormal human endometrium, J.Endocr., 62: 145.

    Google Scholar 

  36. Daniel, L., Martin, P., Escrich, E., Tubiana, N., Fiere, D., and Saez, 1981, Androgen, estrogen and progestin binding sites in human leukemic cells, Int.J.Cancer, 27: 733.

    Article  Google Scholar 

  37. Dao, T.L., and Nemoto, T., 1980, Steroid receptors and response to endocrine ablation in women with metastatic cancer of the breast, Cancer, 46: 2779.

    Article  PubMed  CAS  Google Scholar 

  38. Degenshein, G.A., Bloom, N., and Tobin, E., 1980, The value of progesterone assays in the management of advanced cancer, Cancer, 46: 2789.

    Article  PubMed  CAS  Google Scholar 

  39. Deppe, G., Bruckner, M.W., and Cohen, C.J., 1980, Combination chemotherapy for advanced endometrial adenocarcinoma, Int. J. Gynaec.Obstet., 18: 168.

    Google Scholar 

  40. De Sombre, E.R., 1982, 1982, Breast Cancer: hormone receptors, prognosis and therapy, in:“Clinics in Oncology.Hormone therapy, ” 1, 1, B.J.A. Furr, ed., W.B.Saunders Co.L.t.d., London.

    Google Scholar 

  41. De Sombre, E.R. and Jensen, E.V., 1980, Estrophilin assays in breast cancer: quantitative features and application to the mastectomy specimen, Cancer, 46: 2783.

    Article  Google Scholar 

  42. Donovan, J.F., 1974, Nonhormonal chemotherapy for endometrial adenocarcinoma: a review. Cancer, 34: 1587.

    Article  PubMed  CAS  Google Scholar 

  43. Dougherty, T.F., 1952, Effect of hormones on lymphatic tissues, Physiol.Rev., 32: 379.

    PubMed  CAS  Google Scholar 

  44. Dougherty, T.F., Berliner, M.L., Schneebeli, G.L., and Berliner, D. L., 1964, Hormonal control of lymphatic structure and function, Am.N.Y.Acad.Sci., 113: 825.

    Article  CAS  Google Scholar 

  45. Duval, D., and Homo, F., 1978, Prognostic value of steroid receptor determination in leukemia, Cancer Res., 38: 4263.

    PubMed  CAS  Google Scholar 

  46. Ehrlich, C.E., and Young, P.C.M., 1980, Prediction of hormone-sensitivity in endometrial cancer, Rev.Endocrine-related cancer, 6: 13.

    Google Scholar 

  47. Feherty, P., Robertson, D.M., Waynforth, H.B., and Kellie, A.E., 1970, Changes in the concentrations of high affinity oestradiol receptors in rat uterine supernatant preparations during the oestrus cycle, pseudopregnancy, pregnancy, maturation and after ovariectomy, Biochem.J., 120: 837

    PubMed  CAS  Google Scholar 

  48. Fidler, I.J. and Hardt, I.R., 1981, The origin of metastatic heterogeneity in tumors. Europ.J.Cancer, 17: 487.

    Article  CAS  Google Scholar 

  49. Folca, P.J., Glascock, R.F. and Irvine, W.T., 1961, Studies with tritium

    Google Scholar 

  50. labelled hexoestrol in advanced breast cancer, Lancet, 2:796. Furr, B.J.A., ed., 1982, “Clinics in Oncology. Hormone Therapy, ” W.B. Saunders Co. Ltd., London.

    Google Scholar 

  51. Gailani, S., Minowada, J., Silvermail, P., Nussbaum, A., Kalser, N., Rosen, F., and Shimaoka, K., 1975, Specific glucocorticoid binding in human hemopoietic cell lines and neoplastic tissues, Cancer Res. 33: 2653.

    Google Scholar 

  52. Gehring, U., 1980, Genetic and biochemical studies on glucocorticoid receptors, in:“ Hormones and Cancer”, S.Iacobelli, R.J.B.King, H.R.Lindner, and M.E.Lippman, eds., Raven Press, New York.

    Google Scholar 

  53. Goldin, A., Sandberg, J., Henderson, E., Newman, J., Frei, E., and Holland, J., 1971, The chemotherapy of human and animal acute leukemia, Cancer Chemother. Rept., 55: 309

    Google Scholar 

  54. Griffiths, K., Maynard, P.V., Wilson, D.W., and Davies, P., 1978, Endocrine aspects of primary breast cancer, in:“Review on Endocrinerelated Cancer, ”M.Mayer, S.Saer, and B.A.Stoll, eds., I.C. I. Publishing, U.K.

    Google Scholar 

  55. Gurpide, E., 1981, Hormone receptors in endometrial cancer, Cancer, 48: 638.

    Article  PubMed  CAS  Google Scholar 

  56. Hahnel, R.and Vivian, A.B., 1975, Biochemical and clinical experience with the estimation of estrogen receptors in human breast carcinoma, in: “Estrogen Receptors in Human Breast Cancer”, W.L. Mc Cuire, P.P.Carbone, and E.P.Vollmer, eds., Raven Press, New York.

    Google Scholar 

  57. Hamburger, A.W., Salmon, S.E., and Soehnlen, B., 1978, Quantitation of differential sensitivity of human-tumor stem cells to anticancer drugs, N.Engl.J.Med., 298: 1321.

    Article  PubMed  Google Scholar 

  58. Heuson, J.C., Leclercq, G., Longeval, E., Deboel, M.C., Mattheiem, W.H., and Heiman, R., 1975, Estrogen receptors: Prognostic significance in breast cancer, in: “Estrogen Receptors in Human Breast Cancer”, W.L.Mc Guire, P.P. Carbone and E.P.Vollmer, eds., Raven Press New York.

    Google Scholar 

  59. Homo, F., Duval, D., and Meyer, P., 1975, Etude de la liason de la dexamethasone tritiee dans le lymphocytes des sujets normaux et leucemiques, C.R.Acad.Sci.Paris, t 280: D 1923.

    Google Scholar 

  60. Homo, F., Duval, D., Meyer, P., Debre, P., and Binet, J.L., 1978, Cronic lymphatic leukemia: cellular effect of glucocorticoids in vitro, Br.J.Haematol., 38: 491.

    Article  PubMed  CAS  Google Scholar 

  61. Homo, F., Duval, D., Harousseau, J.L., Marie, J.P., and Zittoun, R., 1980, Heterogeneity of the in vitro responses to glucocorticoids in acute leukemia, Cancer Res., 40: 2601.

    PubMed  CAS  Google Scholar 

  62. Horwitz, K.B., and Mc guire, W.L., 1975, Specific progesterone receptors in human breast cancer, Steroids, 25: 497.

    Article  PubMed  CAS  Google Scholar 

  63. Horwitz, K.B., and Mc Guire, W.L., 1978, Estrogen control of progesterone receptor in human breast cancer. Correlation with nuclear processing of estrogen receptors, J.Biol.Chem., 253: 2223.

    Google Scholar 

  64. Horwitz, K.B., Mc Guire, W.L., Pearson, O.H., and Segaloff, A., 1975 Predicting response to endocrine therapy in human breast cancer: an hypothesis, Science, 189: 726.

    Article  PubMed  CAS  Google Scholar 

  65. Horwitz, K.B., Koseki, Y, and Mc Guire, W.L., 1978, Estrogen control of progesterone receptors in experimental breast cancer: role of estradiol and antiestrogen, Endocrinology, 103: 1742.

    Article  PubMed  CAS  Google Scholar 

  66. Hsueh, A.J.W., Peck, E.J., and Clark, J.H., 1976, Control of uterine estrogen receptor levels by progesterone, Endocrinology, 98: 438.

    Article  PubMed  CAS  Google Scholar 

  67. Iacobelli, S., Ranelletti, P.0., Longo, P., Riccardi, R., and Mastrangelo, R., 1978, Discrepancies between in vivo and in vitro effects of glucocorticoids in myelomonocytic leukemia cells with steroid receptors, Cancer Res., 38: 4257.

    PubMed  CAS  Google Scholar 

  68. Iacobelli, S., Longo, P., Scambia, G., Natoli, V., and Sacco, F., 1980a, Progesterone receptors and hormone sensitivity of human endometrial carcinoma, in: “Role of Medroxyprogesterone in Endocrine-Related Tumors, ” S.Iacobelli, A.Di Marco, eds., Raven Press New York.

    Google Scholar 

  69. Iacobelli, S., Longo, P., Mastrangelo, R., Malandrino, R., Ranelletti, F.O., 1980b, Glucocorticoid receptors and steroid sensitivity of acute lymphoblastic leukemia and thymoma, in:“Hormones and Cancer, ” S.Iacobelli, R.J.B. King, H.Lindner, M.E.Lippman, eds., Raven Press, New York.

    Google Scholar 

  70. Iacobelli, S., King, R.J.B., Lindner, H.R., and Lippman, M.E., 1980c, Hormones and Cancer, Raven Press, New York.

    Google Scholar 

  71. Iacobelli, S., Marchetti, P., Bartoccioni, E., Natoli, V., Scambia, G., and Kaye, A.M., 1981a, Steroid-induced proteins in human endometrium, Molec.Cell Endocrinol., 23: 321.

    Article  PubMed  CAS  Google Scholar 

  72. Iacobelli, S., Natoli, V., Longo, P., Ranelletti, F.O., De Rossi, G., Pasqualetti, D., Mandelli, F., and Mastrangelo, R., 1981b, Glucocorticoid receptor determinations in leukemia patients using cytosol and whole cell-assay, Cancer Res. 41: 3979.

    PubMed  CAS  Google Scholar 

  73. Iacobelli, S., Longo, P., Natoli, V., Sica, G., Bartoccioni, E., Marchetti, P., and Scambia G., 1982, New tools of potential value for predicting hormone responsiveness in human endometrial cancer, in: “The Menopause: Clinical, Endocrinological, and Pathophysio-logical Aspects, ” P.Fioretti, L.Martini, G.B.Melis, S.S.C. Yen, eds., Academic Press, New York.

    Google Scholar 

  74. Iacobelli, S., Natoli, V., Natoli, C., Marchetti, P., Scambia, G., and Kaye, A.M., 1983a, Estrogen induced proteins in normal and neoplastic tissues, in: “Proceedings of the Second Innsbruck Winter Conference on Biochemistry in Clinical Medicine. Hormone-cell interactions in reproductive tissue” (in press), Masson Publ. Inc.New York.

    Google Scholar 

  75. Iacobelli, S., Sica, G., Marchetti, P., Natoli, C., and Natoli, V., 1983 b, Ovarian steroids and tumors, in: “The Ovary, ” G.B.Serra, ed., Raven Press, New York.

    Google Scholar 

  76. Isomaa, V., Isotalo, H., Orava, M., and Janne, 0., 1979, Regulation of cytosol and nuclear progesterone receptors in rabbit uterus by estrogen, antiestrogen and progesterone administration, Biochim.Biophys.Acta, 585: 24.

    Article  PubMed  CAS  Google Scholar 

  77. Janne, O., Kauppila, A., Kontula, K., Syrjala, P., and Vihko, R., 1977, Female sex steroid receptors in normal, hyperplastic and carcinomatous endometrium. The relationship to serum steroid hormones and gonadotropins and changes during medroxyprogesterone acetate administration, Int.J.Cancer, 24: 545.

    Google Scholar 

  78. Jensen, E.V., and Jacobson, H.I., 1962, Basis guides to the mechanism of estrogen action. Rec. Prog. Horm. Res., 18: 387.

    Google Scholar 

  79. Jensen, E.V., Polley, T.Z., Smith, S., Block, G.E., Ferguson, D.J. and De Sombre, E.R., 1975a, Prediction of hormone dependency in human breast cancer, in: “Estrogen Receptors in Human Breast Cancer, ” W.L.Mc Guire, P.P.Carbone, and E.P.Vollmer, eds., Raven Press, New York.

    Google Scholar 

  80. Jensen, E.V., Smith, S., Moran, E.M., and De Sombre, E.R., 1975b, Estrogen receptors and hormone dependency in human breast cancers, in: “Hormones and Breast Cancer, ” M. Namer, ed., INSERM, Paris.

    Google Scholar 

  81. Jonat, W., Maass, H., Stolzenbach, G., and Trams, G., 1980, Estrogen receptor status and response to polychemotherapy in advanced breast cancer, Cancer, 46: 2809.

    Article  PubMed  CAS  Google Scholar 

  82. Kaye, A.M., Reiss, N., Shaer, A., Sluyser, M., Iacobelli, S., Amroch, D., and Soffer, Y., 1981, Estrogen responsive creatin-kinase in normal and neoplastic cells, J. Steroid Biochem., 15: 69.

    Article  PubMed  CAS  Google Scholar 

  83. Kelley, R.M. and Baker, W.H., 1961, Progestational agents in the treatment of carcinoma of the endometrium, New England J. Med. 264: 216.

    Google Scholar 

  84. King, R.J., 1980, Analysis of estradiol and progesterone receptors in early and advanced breast tumors, Cancer, 46: 2818. Kjellestrand, C.M., 1975, Side effect of steroids and their treatment Transpl. Proc., 7: 123.

    Google Scholar 

  85. Knight III, W.A., Livingston, R.B., Gregory, E.J., and MC Guire, W.L., 1977, Estrogen receptor is an independent prognostic factor for early recurrence in breast cancer, Cancer Res., 37: 4669.

    CAS  Google Scholar 

  86. Knight III, W.A., Clark, G.M., Osborne, C.K., and Mc Guire, W.L., 1981

    Google Scholar 

  87. Intensive chemotherapy for estrogen receptor negative, stage II breast cancer, in: “Adjuvant therapy of cancer III, ” S.E. Salmon and S.E.Jones, eds., Grune and Stratton Publ., New York.

    Google Scholar 

  88. Kohorn, E.I., 1976, Gestagens and endometrial carcinoma, Gynec.Oncol., 4: 398.

    Article  CAS  Google Scholar 

  89. Kontula, K., 1980, Glucocorticoid receptors and their role in human disease, Ann.Clin.Res., 12: 233.

    Google Scholar 

  90. Kontula, K., Andersson, L.C., Paavonen, P., Myllyla, G., Teerenhovi, L., and Vuopio, P., 1980, Glucocorticoid receptors and glucocorticoid sensitivity of human leukemia cells, Inter.J.Cancer, 26: 177.

    Article  CAS  Google Scholar 

  91. Kute, T.E., Muss, H.B., Anderson, D., and Wittliff, J.L., 1981, Relationship of steroid receptor and cell kinetics and clinical status in patients with breast cancer. Cancer Res., 41: 3524.

    PubMed  CAS  Google Scholar 

  92. Leake, R.E., Laing, L., Calmon, K.C., 1981, Oestrogen-receptor status stability, Br. J. Cancer, 43: 59.

    Google Scholar 

  93. Leclercq, G. and Heuson, J.C., 1977, Therapeutic significance of sex steroid hormone receptors in the treatment of breast cancer, Europ.J.Cancer, 13: 1205.

    Article  CAS  Google Scholar 

  94. Leclercq, G., Heuson, J.C., Deboel, M.C., and Mattheiem, W.H., 1975, Oestrogen receptors in breast cancer: a changing concept, Br. Med.J., 1: 185.

    Google Scholar 

  95. Lerner, L.J., 1964, Hormone antagonists: inhibitors of specific activities of estrogen and androgen, Recent Prog.Horm.Res., 20: 435.

    PubMed  CAS  Google Scholar 

  96. Lewis, G.C.Jr., Slack, N.H., Martel, R., and Bross, I.D.J., 1974, Adjuvant primary definitive treatment of endometrial cancer, Gynec.Oncol., 2: 368.

    Article  Google Scholar 

  97. Lippman, M.E., 1977, Steroid hormone receptors in human malignancy, Life Sci., 18: 143.

    Article  Google Scholar 

  98. Lippman, M.E., 1980, Steroid receptor analysis and endocrine therapy of breast cancer, in: “Perspectives in steroid receptor research; F.Bresciani, ed., Raven Press, New York.

    Google Scholar 

  99. Lippman, M.E., and Allegra, J.C., 1978, Estrogen receptor and endocrine therapy of breast cancer, N.Engl.J.Med., 299: 930.

    Article  PubMed  CAS  Google Scholar 

  100. Lippman, M.E., and Allegra, J.C., 1980, Quantitative estrogen receptors analysis: the response to endocrine cytotoxic chemotherapy in human breast cancer and the disease free interval, Cancer, 46: 2829.

    Article  PubMed  CAS  Google Scholar 

  101. Lippman, M.E., and Nawata, H., 1982, A genetic analysis of estrogen action in human breast cancer cells, in: “ The role of tamoxifen in breast cancer, ” S.Iacobelli, M.E.Lippman, and G.Robustelli Della Cuna, eds., Raven Press, New York.

    Google Scholar 

  102. Lippman, M.E., and Thompson, E.B., 1979, Pitfalls in the interpretation of steroid receptor assays in clinical medicine, in: “Steroid receptors and the management of cancer, ” vol.1, E.B.Thompson and M.E.Lippman, eds., Boca Raton, Florida, CRC Press.

    Google Scholar 

  103. Lippman, M.E., Halterman, R.H., Leventhal, B.G., Perry, S., and Thompson E.B., 1973a, Glucocorticoid-binding proteins in acute lymphoblastic leukemia blast cells, J. Clin. Invest., 72: 1715.

    Google Scholar 

  104. Lippman, M.E., Halterman, R.H., Perry, S., Leventhal, B.G., Thompson, E.B., 1973b, Glucocorticoid binding proteins in human leukemic lymphoblasts, Nature (New Biol.), 242: 157.

    Article  CAS  Google Scholar 

  105. Lippman, M.E., Perry, S., and Thompson, E.B., 1975, Glucocorticoid binding proteins in myeloblast of acute myelogenous leukemia, Am. J. Med., 59: 224.

    Google Scholar 

  106. Lippman, M.E., Huff, K.K., and Bolan, G., 1977, Progesterone and glucocorticoid interactions with receptors in breast cancer cells in long term culture, N.Y.A.S., 286: 101.

    Article  CAS  Google Scholar 

  107. Lippman, M.E., Allegra, J.C., Thompson, E.B., 1978a, The relation between estrogen receptors and response rate to cytotoxic chemotherapy in metastatic breast cancer, N.Engl.J.Med., 298: 1223

    Article  PubMed  CAS  Google Scholar 

  108. Lippman, M.E., Yarbro, G.K., and Leventhal, B.G., 1978b, Clinical implications of glucocorticoid receptors in human leukemia, Cancer Res., 38: 4251

    PubMed  CAS  Google Scholar 

  109. Livingstone, R.B., and Carter, S.K., eds., 1970, Single agents in cancer chemotherapy, Plenum Press, New York.

    Google Scholar 

  110. Lubbert, H., and Pollow, K., 1978, Correlation between the 17 hydroxysteroid dehydrogenase activity and the estradiol and progesterone receptor concentrations of normal and neoplastic mammary tissue, J.Molecular Med., 1: 175.

    Google Scholar 

  111. Maas, H., Engel, B., Nowakowski, H., 1975, Estrogen receptors in human breast cancer and clinical correlations, in:“ Estrogen Receptors in Human Breast Cancer, ” W.L.Mc Guire, P.P.Carbone, and E.P. Vollmer, eds., Raven Press, New York.

    Google Scholar 

  112. Mac Laughlin, D.T. and Richardson, G.S., 1976, Progesterone binding by normal and abnormal human endometrium, J. Clin. Endocrinol. Metab., 42: 667.

    Google Scholar 

  113. Malkasian, G.D., Decker, D.G., Mossey, E., Johnson, C.E. 1971, Progestin treatment of recurrent endometrial carcinoma, Am. J. Obstet. Gynecol., 110: 15.

    Google Scholar 

  114. Mandelli, F., Amadori, S., Cantù Rajnaldi, A., Cordero di Montezemolo

    Google Scholar 

  115. L., Madon, E., Masera, G., Meloni, G., Pacilli, L., Paolucci, G., Pastore, G., Rosito, P., Uderzo, C., and Vecchi, V., 1980, Discontinuing therapy in childood acute lymphocitic leukemia.A multi-centric survey in Italy, Cancer, 46: 1319.

    Article  Google Scholar 

  116. Manni, A., Arafah, B., and Pearson, O.H., 1980, Estrogen and progesterone receptors in the prediction of response of breast cancer to endocrine therapy, Cancer, 46: 2838.

    Article  PubMed  CAS  Google Scholar 

  117. Marchetti, P;, Natoli, V., Ranelletti, F.O., Mandelli, F., De Rossi, G., and Iacobelli, S., 1981, Glucocorticoids receptors studies in human leukemia, J.Steroid Biochem., 15: 261.

    Article  Google Scholar 

  118. Marchetti, P., Spina, M.A., IIe Rossi, G., Guglielmi, C., Lopez, M., and Iacobelli, S., 1982, Prognostic value of glucocorticoid receptors in acute lymphoblastic leukemia, Proceedings of 3rd International Symposium on Therapy of Acute Leukemias, Rome.

    Google Scholar 

  119. Marchetti, P., Riccardi, R., Mastrangelo, R., and Iacobelli, S., 1983a, Glucocorticoid receptors and “in vivo” corticosensitivity of leukemia lymphoblasts, in: Proceedings of 13th International Congress of Chemotherapy, Vienna.

    Google Scholar 

  120. Marchetti, P., Ranelletti, F.O., Natoli, V., Sica, G., De Rossi, G., Iacobelli, S., 1983b, Presence and steroid inducibility of glutamine synthetase in human leukemic cells, J.Steroid Biochem., in press.

    Google Scholar 

  121. Martin, P.M., Rolland, P.H., Gammerre, M., Serment, H., and Toga, M., 1979, Estradiol and progesterone receptors in normal and neoplastic endometrium: correlations between receptors, histopathologic examination and clinical response under progestin therapy, Int. J.Cancer, 23: 321.

    Google Scholar 

  122. Mastrangelo, R., Malandrino, R., Riccardi, R., Longo, P., Ranelletti, F.O., and Iacobelli, S., 1980, Clinical implications of glucocorticoid receptor studies in childood acute lymphoblastic leukemia, Blood, 56: 1036.

    PubMed  CAS  Google Scholar 

  123. Matsumoto, K., Ochi, H., Nomura, Y., 1978, Progesterone and estrogen receptors in Japanese breast cancer, in: “Hormone receptors and breast cancer, ” W.L. Mc Guire, ed., Raven Press, New York.

    Google Scholar 

  124. Maynard, P.V., Blamey, R.W., Elston, C.W., Haybittle, J.L., and Griffiths, K., 1978, Estrogen receptor assay in primary breast cancer and early recurrence of the disease, Cancer Res., 38: 4292.

    PubMed  CAS  Google Scholar 

  125. Mc Carty, K.S.Jr., Cox, C., Silva, J.S., Woodard, B.H., Mossler, J.A., Haagensen, D.E., Barton, T.K., Mc Carty, K.S.Sr., and Wells, S.A., 1980, Comparison of sex steroid receptor analises and carcina-embryonic antigen with clinical response to hormone therapy, Cancer, 46: 2846.

    Article  Google Scholar 

  126. Mc Guire, W.L., 1980, The usefulness of steroid hormone receptors in the management of primary and advanced breast cancer, in: “Breast cancer: experimental and clinical aspects, ” H.T. Mouridsen and Palshof, eds., Pergamon Press, New York.

    Google Scholar 

  127. Mc Guire, W.L., and Horwitz, K.B., 1978, Progesterone receptors in breast cancer, in: “Hormone Receptors and Breast Cancer, ” W.L. Mc Guire, ed., Raven Press, New York.

    Google Scholar 

  128. Mc Guire, W.L., Carbone, P.P., Sears, M.E., and Escher, G.C., 1975, Estrogen receptors in human breast cancer: an overview, in: “Estrogen receptors in human breast cancer”, W.L.Mc Guire, P.P. Carbone and E.P.Vollmer, eds., Raven Press, New York.

    Google Scholar 

  129. Mc Guire, W.L., Carbone, P.P., and Vollmer, E.P., eds., 1975b, “Estrogen Receptors in Human Breast Cancer, ” Raven Press, New York.

    Google Scholar 

  130. Meyer, J.S., Rao, B.R., Stevens, S.C., and White, W.L., 1977, Low incidence of estrogen receptors in breast carcinomas with rapid rates of cellular replication, Cancer, 40: 2290.

    Article  PubMed  CAS  Google Scholar 

  131. Milgrom, E, Thi, L., Atger, M., and Baulieu, E.E., 1973, Mechanism regulating the concentration and the conformation of progesterone receptor(s) in the uterus, J.Biol.Chem., 248: 6366.

    PubMed  CAS  Google Scholar 

  132. Moon, H., 1936, Inhibition of somatic growth in castrate rats with pituitary extract, Proc.Soc.Exptl.Biol.Med., 37: 34.

    Article  Google Scholar 

  133. Munck, A., and Vira, C., 1971, Glucocorticoid receptors in rat thymus cells, in: “Advances in the Biosciences”, G.L.Raspé, ed., Pergamon Press, Oxford, New York.

    Google Scholar 

  134. Namer, M., Lalanne, C., and Baulieu, E.E., 1980, Increase of progesterone receptor by tamoxifen as a hormonal challenge test in breast cancer, Cancer Res., 40: 1750.

    PubMed  CAS  Google Scholar 

  135. Natoli, V., Marchetti, P., Natoli, C., Sica, G., and Iacobelli, S., 1981, Estrogen and antiestrogen effects on protein synthesis in human breast cancer cells, Curr.Chemother.Immunother., Suppl. 1: 1464.

    Google Scholar 

  136. Natoli, C., Sica, G., Natoli, V., Serra, A., and Iacobelli, S., 1983, Two new estrogen-supersensitive variants of MCF-7 human breast cancer cell line. Breast Cancer Res. and Treat., 3: 1.

    Article  Google Scholar 

  137. Nawata, H., Bronzert, D., and Lippman, M.E., 1981a, Isolation and characterization of a tamoxifen-resistant cell-line derived from MCF-7 human breast cancer cells, J.Biol.Chem., 256: 5016.

    PubMed  CAS  Google Scholar 

  138. Nawata, H., Chong, M.T., Bronzert, D., and Lippman, M.E., 1981b, Estradiolindependent growth of a subline of MCF-7 human breast cancer cells in culture, J.Biol.Chem., 256: 6895.

    PubMed  CAS  Google Scholar 

  139. Nenci, I, Beccati, M.D., Piffanelli, A., and Lanza, G., 1976, Detection and dynamic localization of estradiol-receptor complexes in intact target cells by immunofluorescence tecniques, J.Steroid Biochem., 7: 505.

    Article  PubMed  CAS  Google Scholar 

  140. Neifeld, J.P., Lippman, M.E., and Tormey, D.C., 1977, Steroid hormone receptors in normal human lymphocytes. Induction of glucocorticoid receptor activity by phytoemaggltitinin stimulation, J.Biol. Chem., 252: 2972.

    Google Scholar 

  141. Nicholson, R.I., Campbell, F.C., Blamey, R.W., Elston, C.W., George, D., and Griffiths, K., 1981, Steroid receptors in early breast cancer: value in prognosis, J.Steroid Biochem., 15: 193.

    Article  PubMed  CAS  Google Scholar 

  142. Nicole, I., and Saez, S., 1978, Human breast cancer isolated cells in short term culture: relation between steroid receptors content and the response to hormone addition, Cancer Res., 38: 4314.

    Google Scholar 

  143. Noel, G., Becquart, D., and Maisin, H., 1981, Les recepteurs d’estrogenes dans le cancer du sein. Effet de la radiotherapie pre-operatoire, Senologia, 6: 163.

    Google Scholar 

  144. Nomura, Y., Kobayashi, S., Takatani, I., Sugano, H., Matsumoto, D., and Mc Guire, W.L., 1977, Estrogen receptor and endocrine responsiveness in Japanese versus American breast cancer patients, Cancer Res., 37: 106.

    PubMed  CAS  Google Scholar 

  145. Nomura, Y, Yamagata, J., Takenaka, K., and Tashiro, H., 1980, Steroid hormone receptors and clinical usefulness in human breast cancer, Cancer, 46: 2880.

    Article  PubMed  CAS  Google Scholar 

  146. Nordqvist, R.S.B., 1964, Hormone effects on carcinoma of the human uterine body studied in organ culture. A preliminary report, Acta Obstet.Gynec.Scand., 43: 296.

    Google Scholar 

  147. Nordqvist, R.S.B., 1970, Survival and hormonal responsiveness of endometrial carcinoma in organ culture, Acta Obstet.Gynec.Scand., 49: 275.

    Article  PubMed  CAS  Google Scholar 

  148. Nordqvist, S. 1973, Endometrial cancer. Facts and theories, Path.Ann., 8: 283.

    Google Scholar 

  149. Osborne, C.K., Yochmowitz, M.G., Knight, W.A.III, and Mc Guire, W.L. 1980, The value of estrogen and progesterone receptors in the treatment of breast cancer, Cancer, 46: 2884.

    Article  PubMed  CAS  Google Scholar 

  150. Panko, W.B., and Mac Leod, R.M., 1978, Unchanged nuclear receptors for estrogen in breast cancer, Cancer Res., 38: 1948.

    PubMed  CAS  Google Scholar 

  151. Paridaens, R., Sylvester, R.J., Ferrazzi, E., Legros, N., Leclercq, G. and Heuson, J.C., 1980,. Clinical significance of the quantitative assessment of estrogen receptors in advanced breast cancer, Cancer, 46: 2889.

    Google Scholar 

  152. Piver, M.S., Barlow, J.J., Lurain, J.R., Blumenson, L.E., 1980, Medroxyprogesterone acetate (Depoprovera) vs hydroxyprogesterone caproate ( Delalutin) in women with metastatic endometrial adenocarcinoma, Cancer, 45: 268.

    Google Scholar 

  153. Pollow, K., Lubbert, H., Boquoi, E., Kreuzer, G., and Pollow, B., 1975, Characterization and comparison of receptors for 17 estradiol and progesterone in human proliferative endometrium and endometrial carcinoma, Endocrinology, 96: 319.

    Article  PubMed  CAS  Google Scholar 

  154. Pollow, K., Sinnecker, R., Schmidt-Gollwitzer, M, Boquoi, E., and Pollow, B.

    Google Scholar 

  155. a, Binding of 3H-progesterone to normal and neoplastic tissue samples from tumor bearing breasts, J.Mol.Med. 2: 60.

    Google Scholar 

  156. Pollow, K., Schmidt-Gollwitzer, M., and Nevinny-Stickel, J., 1977b, Progesterone receptors in normal human endometrium and endometrial carcinoma, in: “ Progesterone receptors in normal and neoplasic tissues, ” W.L.McGuire, J.P.Raynaud, E.E.Baulieu, eds., Raven Press, New York.

    Google Scholar 

  157. Pollow, K., Schmidt-Gollwitzer, M., and Pollow, B., 1980, Progesterone and estradiol binding proteins from normal human endometrium and endometrial carcinoma: a comparative study, in:“Steroid receptors and hormone-dependent neoplasia, ”J.L.Wittliff, 0. Dapunt, eds, Masson Publ., New York.

    Google Scholar 

  158. Poulsen, H.S., 1981, Oestrogen receptor assay limitation of the method. Europ.J.Cancer, 17: 496

    Google Scholar 

  159. Ranelletti, F.O., Piantelli, M., Iacobelli, S., Musiani, P., Longo, P., Lauriola, L., Marchetti, P;, 1981, Glucocorticoid receptors and in vitro corticosensitivity of peanut-positive and peanut-negative human thymocyte subpopulations, J. Immunol., 127: 849

    PubMed  CAS  Google Scholar 

  160. Richardson, G.S., and Mac Laughin, D.T. eds., 1978, Hormonal Biology of Endometrial Cancer, vol.42, UICC Technical report series, Geneva. Robel, P., Mortel, R., Levy, C., Namer, M., and Baulieu, E.E.

    Google Scholar 

  161. Steroid receptors and response to an antiestrogen in post-menopausal endometrial carcinoma and metastatic breast cancer, in: “Non-steroidal antiestrogens molecular pharmacology and antitumor activity, ” R.L.Sutherland, ed. Academic Press, New York.

    Google Scholar 

  162. Rochefort, H., Pujol, H., Bressot, N., Lavie, M., Saussol, J., Verone, J., 1980, Effect de la radiotherapie sur la concentration des recepteurs d’estrogenes (RE) et progesterone (RP) dans le cancer du sein, in:“ Recepteurs hormonaux et pathologie mammaire, ” P. M.Martin ed., Medsi Edit.Paris.

    Google Scholar 

  163. Rosen, P.T., Menendez-Botet, C.J., Nisselbaum J.S., Urban, J.A., Mike, V., Fracchia, A., and Schwartz, M.K., 1975, Pathological review of breast lesions analyzed for estrogen receptor protein, Cancer Res. 35: 3187.

    PubMed  CAS  Google Scholar 

  164. Rozier, J.C., and Underwood, P.B., 1974, Use of progestational agents in endometrial adenocarcinoma, Obstet.Gynecol. 44: 60.

    PubMed  Google Scholar 

  165. Saez, S., Martin, P.M., and Chouvet, C.D., 1978, Estradiol and progesterone receptor levels in relation to plasma estrogen and progesterone levels, Cancer Res. 38: 3468.

    PubMed  CAS  Google Scholar 

  166. Sakai, F., and Saez, S., 1976, Existence of receptors bound to endogenous estradiol in breast cancers of premenopausal and postmenopausal women, Steroids 27: 99.

    Article  PubMed  CAS  Google Scholar 

  167. Santi, D., V., Sibley, C.H., Perriard, E.R., Thomkins, G.M., and Baxter, J.D., 1973, A filter assay for steroid hormone receptors, Biochemistry, 12: 2412.

    CAS  Google Scholar 

  168. Schinzinger, A., 1889, Uber carcinoma mammae, Verhandlungen der Deutschen Gesellschaft fur Chirurgie, 18: 28.

    Google Scholar 

  169. Schmidt, T.J., and Thompson, E.B., 1979, Glucocorticoid receptors and glutamine synthetase in leukemic Sezary cells, Cancer Res., 39: 376

    PubMed  CAS  Google Scholar 

  170. Seibert, K., and Lippman, M.E., 1982, Hormone receptors in breast cancer in: “Clinics in Oncology, ” 1, 3, M.Baum, ed. W.B.Saunders, L.t.d., London.

    Google Scholar 

  171. Selye, H., 1937, Studies on adaptation, Endocrinology, 21: 169.

    Article  Google Scholar 

  172. Shaikh, B.S., Dougherty, J.B., Hamilton, R.W., Ballard, J.O., Patel, S.B., Gerviz, N.R., and Eyster, M.E., 1980, Selective use of daunorubicine for remission-induction chemotherapy in acute non lymphoblastic leukemia, Cancer, 46: 1731.

    Article  PubMed  CAS  Google Scholar 

  173. Sherman, A.I., 1966, Progesterone caproate in the treatment of endometrial cancer, Obstet.Gynec., 28: 309.

    PubMed  CAS  Google Scholar 

  174. Silvestrini, R., Daidone, M.G., and Di Fronzo, G., 1979, Relationship between proliferative activity and estrogen receptors in breast cancer, Cancer, 44: 665.

    Article  Google Scholar 

  175. Singhakowinta, A., Mohindra, R., Brooks, S.C., 1975, Clinical correlation of endocrine therapy and estrogen receptor, in: “ Estrogen Receptors in Human Breast Cancer, ” W.L.McGuire, P.P.Carbone, and E.P. Vollmer, eds., Raven Press, New York.

    Google Scholar 

  176. Skinner, L.G., Barnes, D.M., and Ribeiro, G.G., 1980, Simoultaneous estimation of cytoplasmic estrogen and progesterone receptors and nuclear estrogen receptors in human breast tumors and correlation with clinical response, in: “ Steroid receptors and hormone dependent neoplasia, ” J.L.Wittliff and O.Dapunt, eds., Masson Publ. New York.

    Google Scholar 

  177. Sloman, J.C., and Bell, P.A., 1979, Glucocorticoids and myeloid leukemia, in:“ Glucocorticoid action and leukemia, ”, P.A.Bell, N.M.Borthwick, eds. Alpha Omega Publ. L.t.d., Cardiff.

    Google Scholar 

  178. Smith, J.P., 1978, Chemotherapy in gynecologic cancer, Surgical Clinics of North Am, 58: 201.

    CAS  Google Scholar 

  179. Smith, R.G., 1980, Quality control in steroid hormone receptor assays, Cancer, 46: 2946.

    Article  PubMed  CAS  Google Scholar 

  180. Spiers, A.S.D., Goldman, B.M., Catowsky, D., Castello, C., Buskard, N.A., and Galton, D.A.G., 1977, Multiple drug chemotherapy for acute leukemia, Cancer, 40: 20.

    Article  PubMed  CAS  Google Scholar 

  181. Stevens, J., Stevens, Y.W., Sloan, E., Rosenthal, R., Rhodes, J., 1978, Nuclear glucocorticoid binding in chronic lymphocytic leukemia lymphocytes, Endocrinol.Res.Comm., 5: 91.

    Article  CAS  Google Scholar 

  182. Stoll, B.A., 1969, “Hormonal management in breast cancer, ”, Pitman Medical Publishing Company, L.t.d., London.

    Google Scholar 

  183. Stoll, B.A.ed., 1972, “Endocrine Therapy in Malignant Diseases, ” W.B.Saunders Company L., t.d., London.

    Google Scholar 

  184. Stoll, B.A., 1973, Hormonal therapy of gynecological malignancy, Clin. Obste. Gynec., 16: 130.

    Google Scholar 

  185. Swenerton, K.D., 1980, Treatment of advanced endometrial adenocarcinoma with tamoxifen, Cancer Treat.Rep, 64: 805.

    PubMed  CAS  Google Scholar 

  186. Swenerton, K.D., 1982, Endometrial adenocarcinoma, in: “Clinics in oncology. Hormone therapy, ” 1, 1, B.J.A. Furr, ed., W.B.Saunders Co. L.t.d., London.

    Google Scholar 

  187. Takamirawa, H., and Sekiya, S., 1978, Steroid hormone action in uterine cancer, in: “Endocrine control in neoplasia, ” R.K.Sharma and W.E. Criss, eds., Raven Press, New York.

    Google Scholar 

  188. Terenius, L., Lindell, A., and Person, B.H., 1971, Binding of estradiol-17 to human cancer tissue of the female genital tract, Cancer Res., 31: 1895.

    PubMed  CAS  Google Scholar 

  189. Terenius, L., Simonssons, B., and Nilssons, K., 1976, Glucocorticoid receptor, DNA synthesis, membrane antigens and the relation to disease activity in chronic lymphatic leukemia, J.Steroid.Biochem., 7: 905

    Google Scholar 

  190. Tseng, L., Gurpide, E., 1975 a, Effects of progestins on estradiol receptor levels in human endometrium, J.Clin.Endocrinol.Metab. 41: 402.

    Google Scholar 

  191. Tseng, L., Gurpide, E., 1975 b, Induction of human endometrial estradiol dehydrogenase by progestins, Endocrinology, 97: 825.

    Google Scholar 

  192. Vaughan, W.P., Karp, J.E., and Burke, P.J., 1980, Long chemotherapy-free remissions after simple-cycle timed-sequential chemotherapy for acute myelocytic leukemia, Cancer, 45: 859.

    Article  PubMed  CAS  Google Scholar 

  193. Vietti, T.J., Sullivan, M.P., Berry, D.H., Hardy, T., Haggard, M. and Blattner, R., 1965, The response of acute childhood leukemia to an initial and a second course of prednisolone, J.Pediatr, 66: 18.

    Article  PubMed  CAS  Google Scholar 

  194. Westley, B., and Rochefort, H., 1979, Estradiol induced proteins in the MCF-7 human breast cancer cell line, Biochem. Biophys. Res. Comm., 90: 410.

    Google Scholar 

  195. Westley, B., and Rochefort, H., 1980, A secreted glycoprotein induced by estrogen in human breast cancer cell line, Cell, 20: 352.

    Article  Google Scholar 

  196. Wittliff, J.L., 1980, Steroid receptor interactions in human breast carcinoma, Cancer, 46: 2953.

    Article  PubMed  CAS  Google Scholar 

  197. Wittliff, J.L., and Dapunt, 0., eds., 1980, “Steroid receptors and hormone-dependent neoplasia, ” Masson Publ., New York.

    Google Scholar 

  198. Wittliff, J.L., and Savlov, E.D., 1975, Estrogen-binding capacity of cytoplasmic forms of the estrogen receptors in human breast cancer, in: “Estrogen Receptors in Human Breast Cancer, ” W.L.

    Google Scholar 

  199. Mc Guire, P.P.Carbone, and E.P.Vollmer, eds., Raven Press, New York.

    Google Scholar 

  200. Wittliff, J.L., Hilf, R., Brooks, W.F.Jr., Savlov, E.D., Hall, T.C., Orlando, R.A., 1971, Specific estrogen-binding capacity of the cytoplasmic receptor in normal and neoplastic breast tissues of humans, Cancer Res. 32: 1983.

    Google Scholar 

  201. Wittliff, J.L., Mehta, R.G., Lewko, W.M., and Park, D.C., 1982, Ste- roid-receptor interactions in normal and neoplastic mammary tissues, in: “Biochemical markers for cancer, ” T.Ming Chu, ed., M.Dekker Inc., New York.

    Google Scholar 

  202. Yamamoto, K.R., and Alberts, B.M., 1976, Steroid receptors: elements for modulation of eukaryotic transcription, Ann.Rev.Biochem., 45: 721.

    Article  PubMed  CAS  Google Scholar 

  203. Young, P.C., 1979, Gynecologic malignancies, in:“ Cancer Chemotherapy, ” H.M. Pinedo, ed., Elsevier, New York.

    Google Scholar 

  204. Young, P.C., Ehrlich, C.E., and Cleary, P.E., 1976, Progesterone binding in human endometrial carcinomas, Am.J.Obstet.Gynecol., 125:353. Young, P.C., Ehrlich, C.E., and Einhorn, L.H., 1980, Relationship

    Google Scholar 

  205. between steroid receptors and response to endocrine therapy and cytotoxic chemotherapy in metastatic breast cancer, Cancer, 46:2961

    Google Scholar 

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  1. Laboratory of Molecular Endocrinology and Department of Histology, Catholic University of the Sacred Heart, Largo A. Gemelli, 8, 00168, Rome, Italy

    Paolo Marchetti, Giovanni Scambia, Gigliola Sica, Vittoria Natoli & Stefano Iacobelli

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  1. Institute of Pharmacology and Pharacognosy, University of Urbino, Urbino, Italy

    F. Cattabeni

  2. Institute of Pharmacology and Pharmacognosy, University of Milan, Milan, Italy

    S. Nicosia

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Marchetti, P., Scambia, G., Sica, G., Natoli, V., Iacobelli, S. (1984). Steroid Hormone Receptors in Endocrine-Related Tumors. In: Cattabeni, F., Nicosia, S. (eds) Principles and Methods in Receptor Binding. NATO ASI Series, vol 72. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-1577-4_11

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