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Opportunities for Integration of Pharmacokinetics, Pharmacodynamics and Toxicokinetics in Rational Drug Development

  • Carl C. Peck
  • William H. Barr
  • Leslie Z. Benet
  • Jerry Collins
  • Robert E. Desjardins
  • Daniel E. Furst
  • John G. Harter
  • Gerhard Levy
  • Thomas Ludden
  • John H. Rodman
  • Lilly Sanathanan
  • Jerome J. Schentag
  • Vinod P. Shah
  • Lewis B. Sheiner
  • Jerome P. Skelly
  • Donald R. Stanski
  • Robert J. Temple
  • C. T. Viswanathan
  • Judi Weissinger
  • Avraham Yacobi

Abstract

This report derives from the conference on “The Integration of Pharmacokinetic, Pharmacodynamic and Toxicokinetic Principles in Rational Drug Development,” held on April 24–26, 1991 in Arlington, VA. The conference was sponsored by the American Association of Pharmaceutical Scientists, U.S. Food and Drug Administration and the American Society for Clinical Pharmacology and Therapeutics.

Keywords

Dosage Form Drug Development Process Preclinical Animal Model Systemic Drug Concentration Final Dosage Form 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Reference

  1. Skelly, J. P., G. L. Amidon, W. H. Barr, L. Z. Benet, J. E. Carter, J. R. Robinson, V. P. Shah and A. Yacobi (1990). In vitro and in vivo testing and correlation for oral controlled/modified release dosage forms. Pharm. Res. 7 975–982 (1990).Google Scholar

Copyright information

© Springer Science+Business Media New York 1993

Authors and Affiliations

  • Carl C. Peck
    • 1
  • William H. Barr
    • 2
  • Leslie Z. Benet
    • 3
  • Jerry Collins
    • 1
  • Robert E. Desjardins
    • 4
  • Daniel E. Furst
    • 5
  • John G. Harter
    • 1
  • Gerhard Levy
    • 6
  • Thomas Ludden
    • 1
  • John H. Rodman
    • 7
  • Lilly Sanathanan
    • 1
  • Jerome J. Schentag
    • 8
  • Vinod P. Shah
    • 1
  • Lewis B. Sheiner
    • 9
  • Jerome P. Skelly
    • 1
  • Donald R. Stanski
    • 10
  • Robert J. Temple
    • 1
  • C. T. Viswanathan
    • 1
  • Judi Weissinger
    • 1
  • Avraham Yacobi
    • 4
  1. 1.Center for Drug Evaluation and ResearchFDARockvilleUSA
  2. 2.School of PharmacyVirginia Commonwealth UniversityRichmondUSA
  3. 3.School of PharmacyUniversity of CaliforniaSan FranciscoUSA
  4. 4.American Cyanamid Co.Pearl RiverUSA
  5. 5.Ciba-Geigy PharmaceuticalsSummitUSA
  6. 6.State University of New York at BuffaloAmherstUSA
  7. 7.St. Jude Children’s Research HospitalMemphisUSA
  8. 8.Clinical Pharmacokinetics Lab at Millard Fillmore HospitalSUNYBuffaloUSA
  9. 9.University of California Medical CenterSan FranciscoUSA
  10. 10.Department of AnesthesiaVA HospitalPalo AltoUSA

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