The Benzodiazepines: Kinetic-Dynamic Relationships
The primary pharmacologic actions of the benzodiazepine derivatives include: reduction of anxiety, induction of sleep, and anti-seizure effects. Establishing kinetic-dynamic relationships for this class of drugs is a particular challenge, since reliable quantitation of these primary pharmacologic actions is difficult to achieve. This chapter reviews methodologic issues in studying the pharmacokinetic profile and the pharmacodynamic properties of benzodiazepine derivatives, and methods for quantitative linkage of plasma concentrations with clinical effects.
KeywordsPanic Disorder Digit Symbol Substitution Test Intravenous Diazepam Impaired Psychomotor Performance Active Drug Therapy
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