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Regulation of Flow in Vascular Networks by EDRF

  • T M Griffith
  • D H Edwards
Part of the NATO ASI Series book series (NSSA, volume 193)

Abstract

The endothelial lining of arteries is anatomically well sited to convey physiological information about local blood flow to underlying smooth muscle cells, and by releasing endothelium-derived relaxing factor (EDRF) in response to shear stress (Pohl et al., 1986; Rubanyi et al., 1986) mediates flow-dependent dilatation of both conduit (Holtz et al., 1983; Melkumyants et al., 1989) and resistance arteries (Griffith et al., 1987; Griffith and Edwards, 1990). Flow-dependent dilatation provides a way of coordinating responses in different parts of the arterial tree: a metabolically-induced reduction in distal resistance, for example, can produce a secondary fall in the resistance of more proximal “feed vessels” simply as a consequence of the accompanying increase in flow (Holtz et al., 1983).

Keywords

Resistance Artery Geometrical Similarity Asymmetry Ratio Constrictor Response Minimum Power Loss 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Bevan, J.A. and Joyce, E.H., 1988, Flow-dependent contraction observed in a myograph-mounted resistance artery, Blood Vessels. 25: 261–264.Google Scholar
  2. Bevan, J.A., Joyce, E.J. and Wellman, G.C., 1988, Flow-dependent dilation in a resistance artery still occurs after endothelium removal., Circ. Res. 63:980–985.Google Scholar
  3. Busse, R. and Pohl, U., 1989, Role of endothelial cells in the control of vascular tone, in: “Vascular Dynamics”, Nato ASI Series, Plenum Press 1989, pp. 161–175.Google Scholar
  4. Furchgott, R.F., 1983, Role of endothelium in responses of vascular smooth muscle, Circ. Res. 53:557–573.Google Scholar
  5. Griffith, T.M. and Edwards, D.H., 1989, Myogenic autoregulation of flow may be inversely related to EDRF activity, Am. J. Physiol. in press.Google Scholar
  6. Griffith, T.M., Edwards, D.H., Lewis, M.J., Newby, A.C. and Henderson, A.H., 1984, The nature of endothelium-derived relaxant factor, Nature. 308: 645–647.Google Scholar
  7. Griffith, T.M., Edwards, D.H., Davies, R.LI., Harrison, T.J. and Evans, K.T., 1987, EDRF coordinates the behaviour of vascular resistance vessels, Nature. 329: 442–445.Google Scholar
  8. Griffith, T.M., Edwards, D.H., Davies, R.LI., Harrison, T.J. and Evans, K.T., 1988, Endothelium-derived relaxing factor (EDRF) and resistance vessels in an intact vascular bed: a microangiographic study of the rabbit isolated ear, Br. J. Pharmacol. 93:654–662.Google Scholar
  9. Griffith, T.M., Edwards, D.H., Davies, R.U. and Henderson, A.H., 1989, The role of EDRF in flow distribution: a microangiographic study of the rabbit isolated ear, Microvascular Res. 37: 162–177.Google Scholar
  10. Gross, R., Kirchheim, H. and Brandstetter, K., Basal vascular tone in the kidney: evaluation from the static pressure-flow relationship under normal autoregulation and at maximal dilatation in the dog, Circ. Res. 38:525531.Google Scholar
  11. Harder, D.R., 1987, Pressure-induced myogenic activation of cat cerebral arteries is dependent on intact endothelium, Circ. Res. 60:102–107.Google Scholar
  12. Harris, P., 1983, Evolution and the cardiac patient: origins of the blood pressure, Cardiovasc. Res. 17:373–378.Google Scholar
  13. Holtz, J., Giesler, M. and Bassenge, E., 1983, Two dilatory mechanisms of antianginal drugs on epicardial coronary arteries in vivo: indirect, flow-dependent, endothelium mediated dilation and direct smooth muscle relaxation, Z. Kardiol. 72:98–106.Google Scholar
  14. Martin, W., Villani, G.M., Jothianandan, D. and Furchgott, R.F., 1985, Selective blockade of endothelium-dependent and glyceryl trinitrate-induced relaxation by haemoglobin and by methylene blue in the rabbit aorta, Pharmacol. Exp. Ther. 232:708–716.Google Scholar
  15. Melkumyants, A., Balashov, S.A. and Khayutin, V.M., 1989, Endothelium dependent control of arterial diameter by blood viscosity, Cardiovasc. Res. 23:741–747.Google Scholar
  16. Melkumyants, A.M., Balashov, S.A., Veselova, E.S. and Khayutin, V.M., 1987, Continuous control of the lumen of feline conduit arteries by blood flow rate, Cardiovasc. Res. 21:863–870.Google Scholar
  17. Murray, C.D., 1926, The physiological principle of minimum work applied to the angle of branching of arteries, J. Gen. Physiol. 9:835–841.Google Scholar
  18. Nishiye, E., Nakao, K., Itoh, T. and Kuriyama, H., 1989, Factors inducing endothelium-dependent relaxation in the guinea pig basilar artery as estimated from the actions of haemoglobin, Br. J. Pharmacol. 96:645–655.Google Scholar
  19. Pohl, U., Busse, R., Kuon, E. and Bassenge, E., 1986, Pulsatile perfusion stimulates the release of endothelial autocoids, J. Appl. Cardiol. 1:215–235.Google Scholar
  20. Rees, D.D., Palmer, R.M.J., Hodson, H.F. and Moncada, S., 1989, A specific inhibitor of nitric oxide formation from L-arginine attenuates endothelium-dependent relaxation, Br. J. Pharmacol. 96:418–424.Google Scholar
  21. Rubanyi, G.M., Romero, J.C. and Vanhoutte, P.M., 1986, Flow-induced release of endothelium-derived relaxing factor, Am. J. Physiol. 250:H1145–H1149.Google Scholar
  22. Speden, R.N., 1985, The use of excised pressurised blood vessels to study the physiology of vascular smooth muscle, Experentia 41: 1026–1028.Google Scholar
  23. White, D.G. and Martin, W., 1989, Differential control and calcium-dependence of production of endothelium-derived relaxing factor and prostacyclin by pig aortic endothelial cells, Br. J. Pharmacol. 97:683–690.Google Scholar
  24. Woldenberg, M.J. and Horsfield, K., 1986, Relation of branching angles to optimality for four cost principles, J. Theor. Biol. 122:187–204.Google Scholar
  25. Zamir, M, 1976, Optimality principles in arterial branching, J. Theor. Biol. 62:227–251.Google Scholar

Copyright information

© Springer Science+Business Media New York 1990

Authors and Affiliations

  • T M Griffith
    • 1
  • D H Edwards
    • 2
  1. 1.Departments of Diagnostic RadiologyUniversity of Wales College of MedicineCardiffUK
  2. 2.Departments of CardiologyUniversity of Wales College of MedicineCardiffUK

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