Abstract
Bone formation is a biphasic process. During the first phase, the osteoblasts secrete an organic matrix, called preosseous matrix or osteoid, made up of type I collagen and ground substance (proteoglycans, glycoproteins, non-collagenous proteins). During the second phase, mineralization occurs, transforming the osteoid into bone tissue. Analyzed from the morphological viewpoint, three main aspects must be taken into account in osteogenesis of cellular bone: osteoblast dynamics, namely the mechanism by which the osteoblasts modulate the bone appositional growth rate; osteoblast-osteocyte transformation; osteoblast control of collagen orientation.
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Marotti, G. (1990). Morphological and Quantitative Aspects of Bone Formation and Mineralization. In: Pecile, A., de Bernard, B. (eds) Bone Regulatory Factors. NATO ASI Series, vol 184. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-1508-8_3
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DOI: https://doi.org/10.1007/978-1-4757-1508-8_3
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