Pathophysiological Aspects in the Treatment of Post-Menopausal Osteoporosis

  • Angelo Caniggia
  • Ranuccio Nuti
  • Fausto Loré
Conference paper
Part of the NATO ASI Series book series (NSSA, volume 184)


This is the most characteristic clinical finding in post-menopausal osteoporosis (p.m.o.p.): dorsal kyphosis with shortening of the trunk and diminution of the height accounted for by the anterior vertebral crushes.


Bone Mineral Density Bone Mineral Content Postmenopausal Osteoporosis Urinary Calcium Plasma Calcium 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Mazess R.B., Peppler R.W., Chesney R.W., Lange T.A., Lindgren U and Smith E. Jr., 1984, Total body and regional bone mineral by dual-photon absorptiometry in metabolic bone disease, Calcif. Tissue Int. 36: 8.Google Scholar
  2. 2.
    Nuti R., Righi G., Martini G., Turchetti V., Lepore C. and Caniggia A., 1987, Methods and clinical applications of Total Body Absorptiometry. J. Nucl.Med.All. Sciences 31: 213.Google Scholar
  3. 3.
    Albright F. and Reifenstein B.C., 1948, “The parathyroid glands and metabolic bone disease”, Williams & Wilkins Co. Baltimore.Google Scholar
  4. 4.
    Caniggia A., Gennari C., Bianchi V. and Guideri R., 1963, Intestinal absorption of 45Ca in senile osteoporosis, Acta Med. Scand. 173: 613.Google Scholar
  5. 5.
    Kinney V.R., Tauxe V.N. and W.H. Dearing, 1966, Isotopic tracer studies of intestinal calcium absorption, J. Lab. Clin. Med. 66: 187.Google Scholar
  6. 6.
    Parson V., Veall N. and Butterfield W.J.H., 1968, The clinical use of orally administered 47Ca for the investigation of intestinal calcium absorption, Calcif. Tissue Res. 2: 83.Google Scholar
  7. 7.
    Bullamore J.R., Wilkinson R., Gallagher J.C., Nordin B.E.C. and Marshall D.H., 1970, Effects of age on calcium absorption, Lancet II: 535.Google Scholar
  8. 8.
    Szymedera J., Heaney R.P. and Saville P.D., 1979, Intestinal calcium absorption: concurrent use of oral and intravenous tracers and calculation by the inverse convolution method, J. Lab., Clin. Med. 79: 570.Google Scholar
  9. 9.
    Alevizaki C.C., Ikkos D.C. and Singhelakis P., 1973, Progressive decrease of true intestinal calcium absorption with age in normal man. J. Nucl. Med. 14: 760.Google Scholar
  10. 10.
    Gallagher J.C., Aaron J., Horsman A., Marshall D.H., Wilkinson R. and Nordin B.E.C., 1973, The crush fracture syndrome in postmenopausal women, Clinic Endocrinol. Metabol. 2: 293.Google Scholar
  11. 11.
    Ireland P. and Fordtran S., 1973, Effect of dietary calcium and age on jejunal calcium absorption in humans studied by intestinal perfusion, J. Clin., Invest. 52: 2672.Google Scholar
  12. 12.
    Nordin B.E.C., Williams R., Marshall D.H., Gallagher J.C., Williams A. and Peacock M., 1976, Calcium absorption in the elderly. Ilth European Symposium on Calcified Tissues, Calcif. Tissue Res. 215: 422.Google Scholar
  13. 13.
    Lindholm T.S., Sevastikoglou J.A. and Lindgren U., 1977, Treatment of patients with senile post-menopausal and corticosteroid-induced osteoporosis with 1-alpha-hydroxyvitamin D3 and calcium: short and long-term effects, Clin. Endocrinol. 7, Suppl. 183.Google Scholar
  14. 14.
    Sorensen 0.H., Andersen R.B., Christiansen M.S., Friis T., Hjorth L., Jorgensen F.S., Lund B., Melsen F. and Mosekilde L., 1977, Treatment of senile osteoporosis with 1 alpha-hydroxyvitamin D3. Clin. Endocrinol. (Oxf) 7: 169.Google Scholar
  15. 15.
    Heaney R.P., Recker R.R. and Saville P.D., 1978, Menopausal changes in calcium balance performance, J. Lab. Clin. Med. 92: 953.Google Scholar
  16. 16.
    Gallagher J.C., Riggs B.L. and DeLuca H.F. 1980, Intestinal Calcium Absorption and Serum Vitamin D Metabolites in Normal Subjects and Osteoporotic Patients, J. Clin. Invest. 64: 729.Google Scholar
  17. 17.
    Gallagher J.C., Riggs B.L. and DeLuca H.F., 1980, Effect of estrogen on calcium absorption and serum vitamin D metabolites in postmenopausal osteoporosis, J. Clin. Endocrinol. Metab. 53: 833.Google Scholar
  18. 18.
    Riggs B.L., Hamstra A., DeLuca H.F., 1981, Assessment of 25-hydroxyvitamin D-1-hydroxylase reserve in postmenopausal osteoporosis, J. Clin. Endocrinol. Metab. 53: 833.Google Scholar
  19. 19.
    Nordin B.E.C. and Peacock M., 1982, The relation between bone calcium flow, plasma 1,25(OH)2D3 and calcium absorption in post-menopausal women. In: Fifth Workshop on Vitamin D, Historic Williamsburg, Virginia, p. 335, Abstracts.Google Scholar
  20. 20.
    Riggs B.L., 1982, Vitamin D metabolism in involutional osteoporosis: evidence for etiologic heterogeneity. In: Fifth Workshop on vitamin D, Historic Williamsburg, Virginia, p. 324, Abstracts.Google Scholar
  21. 21.
    Loré F., Di Cairano G. Signorini A.M. and Caniggia A., 1981, Serum levels of 25-hydroxyvitamin D in post-menopausal osteoporosis, Calcif.Tissue Int. 33: 467.CrossRefGoogle Scholar
  22. 22.
    Gallagher J.C., Riggs B.L., Eisman J., Hamstra A., Arnaud S.B. and DeLuca H.F., 1979, Intestinal calcium absorption and serum vitamin D metabolites, J. Clin. Invest 64: 729.Google Scholar
  23. 23.
    Lund B., Sorensen 0.H. and Lund B., 1982, Serum 1,25-dihydroxyvitamin D in normal subjects and in patients with postmenopausal osteopenia, Horm. Metab. Res. 14: 271.Google Scholar
  24. 24.
    Loré F., Nuti R., Vattimo A., Caniggia A., 1984, Vitamin D metabolites in postmenopausal osteoporosis, Hormone and Metabolic Research 16: 58.CrossRefGoogle Scholar
  25. 25.
    Caniggia A., Loré F., Di Cairano G., Nuti R., 1987, Main endocrine modulators of vitamin D hydroxylases in human pathophysiology. The Journal of Steroid Biochemistry 27: 815.CrossRefGoogle Scholar
  26. 26.
    Caniggia A. and Vattimo A., 1979, Effects of 1,25-dihydroxycholecalciferol on 47Calcium absorption on post-menopausal osteoporosis, Clin. Endocrinology 11: 99.Google Scholar
  27. 27.
    Caniggia A. and Vattimo A., 1979, Effects of 1,25-dihydroxycholecalciferol on 47Calcium absorption in post-menopausal osteoporosis, Clin. Endocrinology 11: 99.Google Scholar
  28. 28.
    Caniggia A., Gennari C., Borrello G., Bencini M., Cesari L., Poggi C. and Escobar S., 1970, Intestinal absorption of calcium 47 after treatment with oral oestrogen-gestogen in senile osteoporosis, Brit. Med. J., 4: 30.Google Scholar
  29. 29.
    Caniggia A., 1965, Medical problems in senile osteoporosis, Geriatrics 20: 300.Google Scholar
  30. 30.
    Scala C., 1985, Funzioni di densità di probabilità: atlante descrittivo. Tipi Monotypia Franchi. Società Artigiana Tipografica Lama (PG).Google Scholar
  31. 31.
    Marshall D.H. and Nordin B.E.C. 1969, Kinetic analysis of plasma radioactivity after oral ingestion of radiocalcium, Nature 222: 797.Google Scholar
  32. 32.
    Price P.A., Williamson M.K. and Lothringer J.W., 1981, Origin of the vit. K-dependent bone protein found in plasma and its clearance by kidney and bone, J. Biol. Chem. 256: 12760.Google Scholar

Copyright information

© Springer Science+Business Media New York 1990

Authors and Affiliations

  • Angelo Caniggia
    • 1
  • Ranuccio Nuti
    • 1
  • Fausto Loré
    • 1
  1. 1.Institute of Clinical MedicineUniversity of SienaItaly

Personalised recommendations