Osteogenin: Role in Bone Induction and Repair
Bone has considerable potential for repair and regeneration. The aim of this article is to provide a concise review of bone induction. It presents the hypothesis that endogenous growth and differentiation factors isolated from bone matrix in conjunction with exogenous growth factors isolated from elsewhere will initiate and promote cartilage and bone repair. The potential for regeneration and repair of skeletal tissue is well known from the days of Hippocrates in ancient Greece. Almost a century ago Senn (1) described the utility of decalcified bone implants in the care of osteomyelitis. Pierre Lacroix (2), a Belgian orthopaedic surgeon proposed that bone may contain a substance christened “osteogenin” which may initiate bone growth. Marshall Urist (3) made the key discovery that demineralized, lyophilized bone matrix induced bone formation. Bone induction by demineralized bone matrix recapitulates the stages of long bone development (4–7).
KeywordsHigh Performance Liquid Chromatography Bone Formation Bone Matrix Alkaline Phosphatase Activity Demineralized Bone Matrix
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