Actions of the Pineal Gland and Melatonin on the Secretion of Cerebrospinal Fluid

  • W. B. Quay
Part of the NATO Advanced Science Institutes Series book series (NSSA, volume 65)


Association of pineal function with flow or content of the cerebrospinal fluid (CSF) is a very old concept. In western civilization it came into prominent view with the writings of Herophilos of Alexandria (325–280 BC). However, then and through many subsequent centuries, this functional association was based essentially on philosophical speculations, which were contested and eventually discredited, bringing down with them many of the notions derived from, and dependent upon, them. This long and faltering early phase of “pinealology” corresponds to the first of the three periods in pineal research as summarized by Kappers (1979).


Lateral Ventricle Pineal Gland Choroid Plexus Golden Hamster Brain Water Content 
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  1. Agnew, W. F., Yuen, T. G. H., and Achtyl, T. R., 1980, Ultrastructural observations suggesting apocrine secretion in the choroid plexus: A comparative study, Neurological Research, 1: 313.PubMedGoogle Scholar
  2. Allen, D. J., Highison, G. J., Werneck, H., and Gentry, G., 1981, Morphological specializations of the ventricular surface of the choroidal epithelium and associated epiplexus cells, in: Eleventh International Congress of Anatomy: Advances in the Morphology of Cells and Tissues, p. 11, Alan R. Liss, New York.Google Scholar
  3. Arendt, J., Wetterberg, L., Heyden, T., Sizonenko, and Paunier, L., 1977, Radioimmunoassay of melatonin: Human serum and cerebrospinal fluid, Hormone Res., 8: 65.Google Scholar
  4. Brown, G. M., Young, S. N., Gauthier, S., Tsui, H., and Grota, L. J., 1979, Melatonin an human cerebrospinal fluid in daytime: Its origin and variation with age, Life Sci., 25: 929.PubMedCrossRefGoogle Scholar
  5. Davis, D. A., and Milhorat, T. H., 1975, The blood-brain barrier of the rat choroid plexus, Anat. Rec., 181: 779.PubMedCrossRefGoogle Scholar
  6. Decker, J. F., and Quay, W. B., in press, Stimulatory effects of melatonin on ependymal epithelium of choroid plexuses in Golden Hamsters, J. Neural Transmission.Google Scholar
  7. Rusted, R. F., and Reed, D. J., 1976, Regulation of cerebrospinal fluid potassium by the cat choroid plexus, J. Physiol., 259: 213.Google Scholar
  8. Kappers, J. A., 1979, Short history of pineal discovery and research, Prog. Brain Res., 52: 3.PubMedCrossRefGoogle Scholar
  9. Koshiba, K., Oshima, H., and Uematsu, H., 1980, Fine structure of the choroid plexus in pigeon by transmission electron microscopy, J. Electron Microscopy, 29: 129.Google Scholar
  10. Langford, L. A., and Coggeshall, R. E., 1980, The use of potassium ferricyanide in neural fixation, Anat. Rec., 197: 297.PubMedCrossRefGoogle Scholar
  11. Lindvall, M., Edvinsson, L., and Owman, Ch., 1977, Histochemical, ultrastructural and functional evidence for a neurogenic control of cerebrospinal fluid production from the choroid plexus, Acta Physiol. Scand., Suppl. 452: 77.Google Scholar
  12. Masuzawa, T., Saito, T., and Sato, F., 1981, Cytochemical study on enzyme activity associated with cerebrospinal fluid secretion in the choroid plexus and ventricular ependyma, Brain Res., 222: 309.PubMedCrossRefGoogle Scholar
  13. Mess, B., and Trentini, G. P., 1974, 3H-Melatonin level in cerebrospinal fluid and choroid plexus following intravenous administration of the labelled compound, Acta Physiol. Acad. Sci. Hung., 45: 225.Google Scholar
  14. Mollenhauer, H. H., 1964, Plastic embedding mixtures for use in electron microscopy, Stain Technol., 39: 111.PubMedGoogle Scholar
  15. Otani, T., Gy8rkey, F., and Farrell, G., 1968, Enzymes of the human pineal body, J. Clin. Endocrinol. Metab., 28: 349.PubMedCrossRefGoogle Scholar
  16. Perlow, M. J., Reppert, S. M., Boyar, R. M., and Klein, D. C., 1981, Daily rhythms in cortisol and melatonin in primate cerebrospinal fluid. Effects of constant light and dark, Neuroendocrinology, 32: 193.PubMedCrossRefGoogle Scholar
  17. Quay, W. B., 1965, Experimental evidence for pineal participation in homeostasis of brain composition, Prog. Brain Res., 10: 646.PubMedCrossRefGoogle Scholar
  18. Quay, W. B., 1966, Regional differences in metabolism and composition of choroid plexuses, Brain Res., 2: 378.PubMedCrossRefGoogle Scholar
  19. Quay, W. B., 1969, The role of the pineal gland in environmental adaptation, in: “Physiology and Pathology of Adaptation Mechanisms,” E. Bajusz, ed., p. 508, Pergamon Press, Oxford and New York.CrossRefGoogle Scholar
  20. Quay, W. B., 1970a, Experimental studies of brain water content and its 24-hour rhythmicity, Rassegna Neurologia Vegetativa, 24: 1.Google Scholar
  21. Quay, W. B., 1970b, Endocrine effects of the mammalian pineal, Am. Zool., 10: 237.PubMedGoogle Scholar
  22. Quay, W. B., 1972, Regional and quantitative differences in the post-weaning development of choroid plexuses in the rat brain, Brain Res., 36: 37.PubMedCrossRefGoogle Scholar
  23. Quay, W. B., 1974a, “Pineal Chemistry in Cellular and Physiological Mechanisms,” Charles C Thomas, Springfield.Google Scholar
  24. Quay, W. B., 1974b, Temporal mitotic patterns around a brain lesion: Cellular and regional asynchronisms and an effect of pinealectomy, Chronobiologia, 1: 237.PubMedGoogle Scholar
  25. Quinton, P. M., Wright, E. M., and Tormey, J. M., 1973, Localization of sodium pumps in the choroid plexus epithelium. J. Cell Biol., 58: 724.PubMedCrossRefGoogle Scholar
  26. Sahar, A., 1972a, Choroidal origin of cerebrospinal fluid, Israel J. Med. Sci., 8: 594.Google Scholar
  27. Sahar, A., 1972b, The effect of pressure on the production of cerebrospinal fluid by the choroid plexus, J. Neurol. Sci., 16: 49PubMedCrossRefGoogle Scholar
  28. Smith, I., Mullen, P. E., Silman, R. E., Snedden, W., and Wilson, B. W., 1976, Absolute identification of melatonin in human plasma and cerebrospinal fluid, Nature, 260: 718.CrossRefGoogle Scholar
  29. Smith, J. A., Barnes, J. L., and Mee, T. J., 1979, The effect of neuroleptic drugs on serum and cerebrospinal fluid melatonin concentrations in psychiatric subjects, J. Pharm. Pharmacol., 31: 246.PubMedCrossRefGoogle Scholar
  30. Smulders, A. P., and Wright, E. M., 1980, Role of choroid plexus in transport of melatonin between blood and brain, Brain Res., 191: 555.PubMedCrossRefGoogle Scholar
  31. Tan, C. H., and Khoo, J. C. M., 1981, Melatonin concentrations in human serum, ventricular and lumbar cerebrospinal fluids as an index of the secretory pathway of the pineal gland, Hormone Res., 14: 224.PubMedCrossRefGoogle Scholar
  32. Trentini, G. P., Mess, B., De Gaetani, C. F., and Ruzsas, C., 1979, Pineal-brain relationship, Prog. Brain Res., 52: 341.PubMedCrossRefGoogle Scholar
  33. Vaughan, G. M., McDonald, S. D., Jordan, R. M., Allen, J. P., Bohmfalk, G. L., Abou-Samra, M., and Story, J. L., 1978, Melatonin concentration in human blood and cerebrospinal fluid: Relationship to stress, J. Clin. Endocrinol. Metab., 47: 220.PubMedCrossRefGoogle Scholar
  34. Venable, J. H., and Coggeshall, R., 1965, A simplified lead citrate stain for use in electron microscopy, J. Cell Biol., 25: 407.PubMedCrossRefGoogle Scholar
  35. Walter, F. K., 1923, Weitere Untersuchungen zur Pathologie und Physiologie der Zirbeldrüse, Z. Ges. Neurol. Psychiatrie, 83: 411.CrossRefGoogle Scholar
  36. Weiss, M. H., and Wertman, N., 1978, Modulation of CSF production by alterations in cerebral perfusion pressure, Arch. Neurol., 35: 527.PubMedCrossRefGoogle Scholar
  37. Westergaard, E., 1970, “The Lateral Cerebral Ventricles and Their Ventricular Walls,” Andelsbogtrykkeriet, Odense.Google Scholar
  38. Withyachumnarnkul, B., and Knigge, K. M., 1980, Melatonin concentration in cerebrospinal fluid, peripheral plasma and plasma of the confluens sinuum of the rat, Neuroendocrinology, 30: 382.PubMedCrossRefGoogle Scholar
  39. Wright, E. M., 1972, Mechanisms of ion transport across the choroid plexus, J. Physiol., 226: 55.Google Scholar

Copyright information

© Springer Science+Business Media New York 1983

Authors and Affiliations

  • W. B. Quay
    • 1
  1. 1.Neuroendocrine Laboratory, Department of AnatomyUniversity of Texas Medical BranchGalvestonUSA

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