Mechanisms of Microbial Entry and Endocytosis by Mononuclear Phagocytes

  • David M. Mosser
  • Paul J. Edelson
Part of the Contemporary Topics in Immunobiology book series (CTI, volume 13)


Phagocytosis is a primary component of the host defense against invading microorganisms. Macrophages, working in concert with cellular and humoral immune mechanisms, are active both in clearing organisms from the blood or tissues and in killing and degrading them once they have been ingested. In this chapter we examine the molecular recognition mechanisms involved in the interaction of microbial pathogens with the macrophages and how these interactions contribute either to eradication of the invaders or to their ultimate ability to survive in the host. To that end, we review the physiology of phagocytosis, the classes of membrane binding sites currently recognized on the macrophage, the alteration of these binding sites upon macrophage activation, and the ways in which these sites may contribute to or oppose microbial infection. We are especially interested in examining the hypothesis that the initial plasma membrane binding mechanisms play important roles in determing the ultimate intracellular fate of phagocytized organisms.


Visceral Leishmaniasis Respiratory Burst Complement Receptor Mouse Peritoneal Macrophage Trypanosoma Brucei 


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Copyright information

© Springer Science+Business Media New York 1984

Authors and Affiliations

  • David M. Mosser
    • 1
  • Paul J. Edelson
    • 1
  1. 1.Division of Infectious Diseases and Immunology Department of PediatricsCornell Medical CollegeNew YorkUSA

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