Skip to main content
SpringerLink
Log in

Possible Autoregulatory Functions of the Secretory Products of Mononuclear Phagocytes

  • Chapter
Macrophage Activation

Part of the book series: Contemporary Topics in Immunobiology ((CTI,volume 13))

  • 60 Accesses

Abstract

The ability of mononuclear phagocytes to recognize, ingest, and either digest or remove through various portals of exit from the body a wide variety of infectious agents and toxic materials has been recognized since the seminal observations of Metchnikoff. Mononuclear phagocytes have specialized recognition mechanisms that facilitate these functions, which include (1) several classes of Fc receptors for immune complexes; (2) responsiveness to lymphokines, which serve to enhance their phagocytic and cidal functions; and (3) receptors for complement components, which are either chemotactic or facilitate phagocytosis. During the past decade it became clear that these activities, concerned primarily with the removal of noxious stimuli from the host environment, are accompanied by other specialized functions that have far-reaching effects on the cells and connective tissues present in the pericellular environment of the mononuclear phagocyte. One of these, the ability to present antigenic determinants of ingested materials to cells of the immune system in an immunogenic form (for review, see Rosenthal, 1980), is not discussed here. The other, the ability of mononuclear phagocytes to secrete a diverse range of products, preoccupied many investigators during the past decade.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
eBook
USD 16.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 16.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Ackerman, S. K., Friend, P. S., Hoidal, J. R., and Douglas, S. D., 1978, Production of C2 by human alveolar macrophages, Immunology 35: 369–372.

    PubMed  CAS  Google Scholar 

  • Alitalo, K., Hovi, T., and Vaheri, A., 1980, Fibronectin is produced by human macrophages, J. Exp. Med. 151: 602–613.

    Article  PubMed  CAS  Google Scholar 

  • Banda, M., Clark, E. J., and Werb, Z., 1980, Limited proteolysis by macrophage elastase inactivates human a, -proteinase inhibitor, J. Med. Exp. 152: 1563–1570.

    Article  CAS  Google Scholar 

  • Banda, M., and Werb, Z., 1981, Mouse macrophage elastase. Purification and characterization as a metalloproteinase, Biochem. J. 193: 589–605.

    PubMed  CAS  Google Scholar 

  • Bentley, C., Hadding, U., Bitter-Suermann, D., and Brade, V., 1977, Effect of in vivo stimulation of mice on the secretion of factor B of the alternative complement pathway by peritoneal macrophages, Eur. J. Immunol. 7: 188–190.

    Article  PubMed  CAS  Google Scholar 

  • Bentley, C., Fries, W., and Brade, V., 1978, Synthesis of factors D, B and P of the alternative pathway of complement activation, as well as of C3 by guinea pig peritoneal macrophages in vitro, Immunology 35: 971–980.

    PubMed  CAS  Google Scholar 

  • Bevilacqua, M. P., Amrani, D., Mossesson, M. W., and Bianco, C., 1981, Receptors for cold insoluble globulin (plasma fibronectin) on human monocytes, J. Exp. Med. 153: 42–60.

    Article  PubMed  CAS  Google Scholar 

  • Bonney, R. J., Wightman, P. D., Davies, P., Sadowski, S., Kuehl, F. A., Jr., and Humes, J. L., 1978, Regulation of prostaglandin synthesis and of the release of lysosomal hydrolases by mouse peritoneal macrophages, Biochem. J., 176: 433–442.

    PubMed  CAS  Google Scholar 

  • Bonney, R. J., Naruns, P., Davies, P., and Humes, J. L., 1979, Antigen-antibody complexes stimulate the synthesis and release of prostaglandins by mouse peritoneal macrophages, Prostaglandins 18: 605–616.

    Article  PubMed  CAS  Google Scholar 

  • Bonney, R. J., Wightman, P. D., Dahlgren, M. E., Davies, P., Kuehl, F. A., Jr., and Humes, J. L., 1980a, Release of inflammatory mediators by macrophages in response to phorbol myristate acetate: Effect of RNA and protein synthesis inhibitors, Biochim. Biophys. Acta 633: 410–421.

    Article  PubMed  CAS  Google Scholar 

  • Bonney, R. J., Burger, S., Kuehl, F. A., Jr., and Humes, J., 1980b, Prostaglandin E2 and prostacyclin elevate cAMP levels in elicited but not resident populations of macrophages, Adv. Prostaglandin Thromboxane Res. 8: 1691–1693.

    PubMed  CAS  Google Scholar 

  • Brade, V., Hall, R. E. and Colten, H., 1977, Biosynthesis of pro-C3, a precursor of the third component of complement, J. Exp. Med. 146: 759–765.

    Article  PubMed  CAS  Google Scholar 

  • Bradley, J. R., and Metcalf, D., 1966, The growth of mouse bone marrow cells in vitro, Aust. J. Exp. Bio. Med. Sci. 44: 287–293.

    Article  CAS  Google Scholar 

  • Broxmeyer, H. E., Mendelsohn, N., and Moore, M. A. S., 1977, Abnormal granulocyte feedback regulation of colony stimulating activity-producing cells from patients with chronic myelogenous leukemia, Leukemia Res. 1: 3–12.

    Article  Google Scholar 

  • Brune, K., Glatt, M., Kalin, H., and Peskar, H., 1978, Pharmacological control of prostoglandin and thromboxane release from macrophages, Nature 274: 261–263.

    Article  PubMed  CAS  Google Scholar 

  • Burger, R., Hadding, U., Schorlemmer, H. U., Brade, V., and Bitter-Suerman, D., 1975, Dextran sulphate: A synthetic activator of C3 via the alternative pathway. I. Influence of molecular size and degree of sulphation on the activation potency, Immunology 29: 549–554.

    PubMed  CAS  Google Scholar 

  • Chenoweth, D. E., Goodman, M. G., and Weigle, W. O., 1982, Demonstration of a specific receptor for human C5a anaphylatoxin on murine macrophages, J. Exp. Med. 156: 6878.

    Article  Google Scholar 

  • Chervenick, P. A., and LoBuglio, A. E., 1972, Human blood monocytes: stimulators of granulocyte and mononuclear colony formation in vitro, Science 178:164–166.

    Article  PubMed  CAS  Google Scholar 

  • Colten, H., 1976, Biosynthesis of complement, Adv. Immunol. 22: 67–118.

    Article  PubMed  CAS  Google Scholar 

  • Colten, H. R., and Borsos, T., 1974, Biosynthesis of the second and fourth components of complement: Inhibition in vitro by chemical carcinogens, J. Immunol. 112: 1107 1114.

    PubMed  CAS  Google Scholar 

  • Dahlgren, M. E., Davies, P., and Bonney, R. J., 1980, Phorbol myristate acetate induces the secretion of an elastase by populations of resident and elicited mouse peritoneal macrophages, Biochim. Biophys. Acta 630: 338–351.

    Article  PubMed  CAS  Google Scholar 

  • Davies, P., and Bonney, R. J., 1979, Secretory products of mononuclear phagocytes, J. Reticuloendothel. Soc. 26: 37–47.

    PubMed  CAS  Google Scholar 

  • Davies, P., and Bonney, R. J., 1980, The secretion of hydrolytic enzymes by mononuclear phagocytes, in: The Cell Biology of Inflammation ( G. Weissmann, ed.), pp. 497–542, Elsevier North-Holland, New York.

    Google Scholar 

  • Davies, P., Bonney, R. J., Humes, J. L, and Kuehl, F. A., Jr., 1980, The synthesis of arachidonic acid oxygenation products by various mononuclear phagocyte populations, in: Mononuclear Phagocytes, Functional Aspects ( R. van Furth, ed.), pp. 1317–1350, Martinus Nijhoff, The Hague.

    Google Scholar 

  • Einstein, L. P., Alper, C. A., Bloch, K. J., Herin, J. T., Rosen, F. S., David, J. R., and Colten, H. R., 1975, Biosynthetic defect in monocytes from human beings with genetic deficiency of the second component of complement, N. Engl. J. Med. 292: 1169–1171.

    Article  PubMed  CAS  Google Scholar 

  • Einstein, L. P., Schneeberger, E. E., and Colten, H. R., 1976, Synthesis of the second component of complement by long-term primary cultures of human monocytes, J. Exp. Med. 143: 114–126.

    Article  PubMed  CAS  Google Scholar 

  • Fels, A. O. S., Pawlowski, N. A., Cramer, E. B., King, T. K. C., Cohn, Z. A., and Scott, W. A., 1982, Human alveolar macrophages produce leukotriene B4, Proc. Natl. Acad. Sci. USA 79: 7866–7870.

    Article  PubMed  CAS  Google Scholar 

  • Feuerstein, N., Bash, J. A., Woody, J. N., and Ramwell, P. W., 1981, Leukotriene C stimulates prostaglandin release from rat peritoneal macrophages, Biochem. Biophys. Res. Commun. 100: 1085–1090.

    Article  PubMed  CAS  Google Scholar 

  • Gallin, E. K., and Gallin, J. I., 1977, Interaction of chemotactic factors with human macrophages. Induction of transmembrane potential changes, J. Cell Biol. 75: 277–289.

    Google Scholar 

  • Gemsa, D., Seitz, M., Kramer, W., Till, G., and Resch, K., 1979, The effects of phagocytosis, dextran sulfate, and cell damage on PGE1 sensitivity and PGE, production of macrophages, J. Immunol. 120: 1187–1194.

    Google Scholar 

  • Goodman, M. G., Chenoweth, D. E., and Weigle, W. O., 1982a, Potentiation of the primary humoral immune response in vitro by C5a anaphylatoxin, J. Immunol. 129: 70–75.

    PubMed  CAS  Google Scholar 

  • Goodman, M. G., Chenoweth, D. E., and Weigle, Wo. O., 1982b, Induction of interleukin 1 secretion and enhancement of humoral immunity by binding of human C5a to macrophage surface C5a receptors, J. Exp. Med. 156: 912–917.

    Article  PubMed  CAS  Google Scholar 

  • Gordon, S., 1980, Lysozyme and plasminogen activator: Constitutive and induced secretory products of mononuclear phagocytes, in: Mononuclear Phagocytes, Functional Aspects ( R. Van Furth, ed.), pp. 1273–1298, Martinus Nijhoff, The Hague.

    Google Scholar 

  • Gotze, O., Bianco, C., and Cohn, Z. A., 1979, The induction of macrophage spreading by Factor B of the properdin system, J. Exp. Med. 149: 372–386.

    Article  PubMed  CAS  Google Scholar 

  • Gudewicz, P. W., Molnar, J., Lai, M. Z., Beezhold, D. W., Siefring, Jr., G. E., Credo, R. B., and Lorand, L., 1980, Fibronectin mediated uptake of gelatin coated latex particles by peritoneal macrophages, J. Cell Biol. 87: 427–433.

    Article  PubMed  CAS  Google Scholar 

  • Guilbert, L. J., and Stanley, E. R., 1980, Specific interaction of murine colony-stimulating factor with mononuclear phagocytic cells, J. Cell. Biol. 85: 153–159.

    Article  PubMed  CAS  Google Scholar 

  • Hamilton, J. A., 1981, Regulation of prostaglandin and plasminogen activator production by mouse peritoneal macrophages, J. Reticuloendothel. Soc. 30: 115–128.

    PubMed  CAS  Google Scholar 

  • Hibbs, J. R., Lambert, L. H., and Remington, J. S., 1971, Resistance to murine tumors conferred by chronic infection with intracellular protozoa, Toxoplasma gondii and Resonitia jellisoni, J. Infect. Dis 124: 587–591.

    Article  PubMed  Google Scholar 

  • Hovi, T., Mosher, D., and Vaheri, A., 1977, Cultured human monocytes synthesize and secrete a2-macroglobulin, J. Exp. Med. 145: 1580–1589.

    Article  PubMed  CAS  Google Scholar 

  • Hsueh, W., and Sun, F. F., 1982, Leukotriene by biosynthesis by alveolar macrophages, Bioch. Biophys. Res. Commun. 106: 1085–1091.

    Article  CAS  Google Scholar 

  • Humes, J. L., Bonney, R. J., Pelus, L., Dahlgren, M. E., Sadowski, S. J., Kuehl, F. A., Jr., and Davies, P., 1977, Macrophages synthesize and release prostaglandins in response to inflammatory stimuli, Nature 269: 149–151.

    Article  PubMed  CAS  Google Scholar 

  • Humes, J. L., Sadowski, S., Galavage, M., Kuehl, F. A., Jr., Wightman, P. D., Dahlgren, M. E., Davies, P., and Bonney, R. J., 1980, The diminished production of arachidonic acid oxygenation products by elicited peritoneal macrophages: Possible mechanisms, J. Immunol. 124: 2110–2116.

    PubMed  CAS  Google Scholar 

  • Humes, J. L., Sadowski, S., Galavage, M., Goldenberg, M., Subers, E., Bonney, R. J., and Kuehl, F. A., Jr., 1982, Evidence for two sources of arachidonic acid for oxidative metabolism by mouse peritoneal macrophages, J. Biol. Chem. 257: 1591–1594.

    PubMed  CAS  Google Scholar 

  • Johansson, S., Rubin, K., Hook, M., Ahigren, T., and Seljelid, D. R., 1979, In vitro biosynthesis of cold insoluble gloublin (fibronectin) by mouse peritoneal macrophages, FEBS Lett. 105: 313–316.

    CAS  Google Scholar 

  • Johnson, W. J., Pizzo, S. V., Imber, M. J., and Adams, D. O., 1982, Receptors for maleylated proteins regulate secretion of neutral proteases by murine macrophages, Science 218: 574–576.

    Article  PubMed  CAS  Google Scholar 

  • Kaplan, J, 1980, Evidence for reutilization of surface receptors for a-macroglobulin protease complexes in rabbit alveolar macrophages, Cell 19: 197–205.

    Article  PubMed  CAS  Google Scholar 

  • Kaplan, J., and Nielsen, M. L., 1979a, Analysis of macrophage surface receptors. 1. Binding of a-macroglobulin-protease complexes to rabbit alveolar macrophages, J. Biol. Chem. 254: 7323–7328.

    PubMed  CAS  Google Scholar 

  • Kaplan, J. and Nielsen, M. L., 1979b, Analysis of macrophage surface receptors. II. Internalization of a-macroglobulin-trypsin complexes by rabbit alveolar macrophages, J. Biol. Chem. 254: 7329–7335.

    PubMed  CAS  Google Scholar 

  • Kurland, J. J., and Bockman, R., 1978, Prostaglandin E production by human blood monocytes and mouse peritoneal macrophages, J. Exp. Med. 147: 952–957.

    CAS  Google Scholar 

  • Kurland, J. I., Pelus, L. M., Ralph, P., Bockman, R. S., and Moore, M. A. S., 1979, Induction of prostaglandin E synthesis in normal and neoplastic macrophages: Role for colony-stimulating factor(s) distinct from effects on myeloid progenitor cell proliferation, Proc. Natl. Acad. Sci. USA 76: 2326–2330.

    Article  PubMed  CAS  Google Scholar 

  • Lai A Fat, R. F. M., and Van Furth, R., 1975, In vitro synthesis of some complement components (Clq, C3 and C4) by lymphoid tissues and circulating leucocytes in man, Immunology 28: 359–368.

    Google Scholar 

  • Lappin, D., and Whaley, K., 1981, Cyclic AMP-mediated modulation of the production of the second component of human complement by monocytes, Int. Arch. Allergy A p pl. Immunol. 65: 85–90.

    Article  PubMed  CAS  Google Scholar 

  • Lappin, D. F., and Whaley, K., 1982, Prostaglandins and prostaglandin synthetase inhibitors regulate the synthesis of complement components by human monocytes, Clin. Exp. Immunol. 49: 623–630.

    PubMed  CAS  Google Scholar 

  • Littleton, C., Kessler, D., and Burkholder, T. M., 1970, Cellular basis for the synthesis of the fourth component of guinea pig complement as determined by a hemolytic plaque technique, Immunology 18: 693–704.

    PubMed  CAS  Google Scholar 

  • Littman, B. H., and Ruddy, S., 1977, Production of the second component of complement by human monocytes: Stimulation by antigen-activated lymphocytes or lymphokines, J. Exp. Med. 145: 1344–1352.

    Article  PubMed  CAS  Google Scholar 

  • McCarthy, K., and Henson, P. M., 1979, Induction of lysosomal enzyme secretion by alveolar macrophages in response to purified complement fragments C5a and CSades arg’ J. Immunol. 123: 2511–2517.

    PubMed  CAS  Google Scholar 

  • McCarthy, M. E., and Zwilling, B. S., 1981, Differential effects of prostaglandins on antitumor activity of normal and BCG-activated cells, Immunology 60: 91–99.

    CAS  Google Scholar 

  • McClelland, D. B. L., and Van Furth, R., 1976, In vitro synthesis of ß1C/131A globulin (the C3 component of complement) by tissues and leucocytes of mice, Immunology 31: 855–861.

    CAS  Google Scholar 

  • Mencia-Huerta, J-M, and Benveniste, J., 1979, Platelet-activating factor and macrophages I. Evidence for the release from rat and mouse peritoneal macrophages and not from mastocytes, Eur. J. Immunol. 9: 409–415.

    Article  PubMed  CAS  Google Scholar 

  • Mencia-Huerta, J-M., Roubin, R., Morgot, J-L, and Benveniste, J., 1982, Biosynthesis of platelet-activating factor, III. Formation of PAF-acether synthetic substrates by stimulated murine macrophages, J. Immunol. 129: 804–808.

    PubMed  CAS  Google Scholar 

  • Mosher, D. F., Saksela, O., Keski-Oja, J., and Vaheri, A., 1977, Distribution of a major surface-associated glycoprotein, fibronectin, in cultures of adherent cell, J. Supramol. Struct. 6. 551–557.

    Article  PubMed  CAS  Google Scholar 

  • Mueller, W., Anausje-Abel, M., and Loos, M., 1978, Biosynthesis of the first component of complement by human and guinea pig peritoneal macrophages: Evidence for independent production of Cl subunits, J. Immunol. 121: 1578–1584.

    CAS  Google Scholar 

  • Murray, J. L., 1982, Prostaglandin E2 modulation of human monocyte antibody-dependent cell-mediated cytotoxicity against human red cells, Cell Immunol. 71:196–201.

    Article  PubMed  CAS  Google Scholar 

  • Nathan, C. F., Murray, H. U., and Cohn, Z. A., 1982, The macrophage as an effector cell, N. Engl. J. Med. 303: 622–626.

    Article  Google Scholar 

  • Norris, D. A., Clark, R. A. F., Swigart, L. M., Huff, J. C., Weston, W. M., and Howell, S. E., 1982, Fibronectin fragment(s) are chemotactic for human peripheral blood monocytes, J. Immunol. 129: 1612–1618.

    PubMed  CAS  Google Scholar 

  • North, R. J., Kirstein, D. P., and Remington, J. S., 1976, Subversion of host defense mechanisms by murine tumors. I. A circulating factor that suppresses macrophage-mediated resistance to infection, J. Exp. Med 143: 559–573.

    Article  PubMed  CAS  Google Scholar 

  • Ooi, Y. M., and Colten, H. M., 1979, Genetic defect in secretion of complement CS in mice, Nature 282: 207–208.

    Article  PubMed  CAS  Google Scholar 

  • Oropeza-Rendon, R. L., Speth, V., Heller, G., Weber, K., and Fisher, H., 1979, Prostaglandin E1 reversibly induces morphological changes in macrophages and inhibits phagocytosis, Exp. Cell Res. 119: 365–371.

    Article  PubMed  CAS  Google Scholar 

  • Pelus, L. M., Broxmeyer, H. E., Kurland, J. I., and Moore, M. A. S., 1979, Regulation of macrophage and granulocyte proliferation, J. Exp. Med. 150: 277–292.

    Article  PubMed  CAS  Google Scholar 

  • Pelus, L. M., Broxmeyer, H. E., Clarkson, B. D., and Moore, M. A. S., 1980, Abnormal responsiveness of granulocyte-macrophage committed colony forming cells from patients with chronic myeloid leukemia to inhibition by prostaglandin E, Cancer Res. 40: 2512–2515.

    PubMed  CAS  Google Scholar 

  • Picker, L. J., Raff, H. V., Goldyne, M. E., and Stobo, J. D., 1980, Metabolic heterogenity among human monocytes and its modulation by PGE2, J. Immunol. 124: 2557–2562.

    PubMed  CAS  Google Scholar 

  • Postlethwaite, A. E., Keski-Oja, J., Balian, G., and Kang, A. H., 1981, Induction of fibroblast chemotaxis by fibronectin. Localization of the chemotactic region to a 140,000-molecular weight non-gelatin-binding fragment, J. Exp. Med. 153: 494–499.

    Article  PubMed  CAS  Google Scholar 

  • Rennard, S. I., Berg, R., Martin, G. R., Foidart, J. M., and Gehron-Robey, P., 1980, Ensyme-linked immunoassay (ELISA) for connective tissue components, Anal. Biochem. 104: 205–214.

    Article  PubMed  CAS  Google Scholar 

  • Rennard, S. I., Hunninghake, G. W., Bitterman, P. B., and Crystal, R. G., 1981, Production of fibronectin by the human alveolar macrophage: Mechanism for the recruitment of fibroblasts to sites of tissue injury in interstitial lung diseases, Proc. Natl. Acad. Sci. USA 78: 7147–7151.

    Article  PubMed  CAS  Google Scholar 

  • Rosenthal, A. S., 1980, Regulation of the immune response-role of the macrophage, N. Engl. J. Med. 303: 1153–1156.

    Article  PubMed  CAS  Google Scholar 

  • Rouzer, C. M., Scott, W. A., Conn, Z. A., Blackburn, P., and Manning, J., 1980, Mouse peritoneal macrophages release leukotriene C in response to a phagocytic stimulus, Proc. Natl. Acad. Sci. USA 77: 4928–4932.

    Article  PubMed  CAS  Google Scholar 

  • Rouzer, C. M., Scott, W. A., Hamill, A. L., and Cohn, Z. A., 1982, Synthesis of leukotrienes and other arachidonic acid metabolites by mouse peritoneal macrophages, J. Exp. Med. 155: 720–733.

    Article  PubMed  CAS  Google Scholar 

  • Ruoslahti, E., Pierschbacher, M., Hayman, E. G., and Engvalle, E., 1982, Fibronectin: A molecule with remarkable structural and functional diversity, Trends Biochem. Sci. 7: 188–190.

    Article  CAS  Google Scholar 

  • Rutherford, B., and Schenken, H. A., 1983, C3 cleavage products stimulate release of prostaglandins by human mononuclear phagocytes in vitro, J. Immunol. 130: 874–877.

    PubMed  CAS  Google Scholar 

  • Schenkelaars, E. J., and Bonta, I. L., 1983, Effect of leukotriene C4 on the release of secretory products by elicited populations of rat peritoneal macrophages, Eur. J. Pharmacol. 86: 477–480.

    Article  PubMed  CAS  Google Scholar 

  • Scher, M. G., Beller, D. I., and Unanue, E. R., 1980, Demonstration of a soluble mediator that induces exudates rich in Ia-positive macrophages, J. Exp. Med. 152: 1684–1693.

    Article  PubMed  CAS  Google Scholar 

  • Schnyder, J., Dewald, B., and Baggiolini, M., 1981, Effects of cyclooxygenase inhibitors and prostaglandin E2 on macrophage activation in vitro, Prostaglandins 22: 411–421.

    Article  PubMed  CAS  Google Scholar 

  • Schorlemmer, H. U., and Allison, A. C., 1976, Effects of activated complement components on enzyme secretion by macrophages, Immunology 31: 181–186.

    Google Scholar 

  • Schorlemmer, H. U. Davies, P., and Allison, A. C., 1976, Ability of activated complement components to induce lysosomal enzyme release from macrophages, Nature 261: 48–49.

    Article  PubMed  CAS  Google Scholar 

  • Schorlemmer, H. U., Bitter-Suerman, D., and Allison, A. C., 1977, Complement activation by the alternative pathway and macrophage enzyme secretion in the pathogenesis of chronic inflammation, Immunology 32: 929–940.

    PubMed  CAS  Google Scholar 

  • Schultz, R. M., Pavlidis, N. A., Styles, W. A., and Chirigos, M. A., 1978; Regulation of macrophage tumorcidal function: A role for prostaglandins of the E series, Science 202: 320–321.

    CAS  Google Scholar 

  • Scott, W. A., Rouzer, C. A., and Cohn, Z. A., 1983, Leukotriene C release by macrophages, Fed. Proc. 42: 129–133.

    PubMed  CAS  Google Scholar 

  • Smith, R. L., Hunt, N. H., Merritt, J. E., Evans, T., and Weidemann, M. J., 1980, Cyclic nucleotide metabolism and reactive oxygen production by macrophages, Biochem. Biophys. Res. Commun. 96: 1079–1087.

    Article  PubMed  CAS  Google Scholar 

  • Snyder, D. S., Lu, C. Y., and Unanue, E. R., 1982a, Control of macrophage Ia expression in neonatal mice role of a splenic suppressor cell, J. Immunol. 128: 1458–1465.

    PubMed  CAS  Google Scholar 

  • Snyder, D. S., Beller, D. I., and Unanue, E. R., 1982b, Prostaglandins modulate macrophage Ia expression, Nature 299: 163–165.

    Article  PubMed  CAS  Google Scholar 

  • Stecher, V., 1970, Synthesis of proteins by mononuclear phagocytes, in: Mononuclear Phagocytes ( R. Van Furth, ed.), pp. 133–150, F. A. Davis, Philadelphia.

    Google Scholar 

  • Steeg, P. S., Johnson, H. M., and Oppenheim, J. J., 1982, Regulation of murine macrophage la antigen expression by an immune interferon-like lymphokine: Effect of endotoxin, J. Immunol. 129: 2402–2406.

    PubMed  CAS  Google Scholar 

  • Taffet, S. M., and Russell, S. W., 1980, Macrophage mediated tumor cell killing: Regulation of expression of cytolytic activity by prostaglandin E., J. Immunol. 126: 424–427.

    Google Scholar 

  • Taffet, S. M., Eurell, T. E., and Russell, S. W., 1982, Regulation of macrophage-mediated tumor cell killing by prostagladins: comparison of PGE2 and PGI2, Prostaglandins 24: 763–774.

    Article  PubMed  CAS  Google Scholar 

  • Tushinski, R. J., Oliver, I. T., Guilbert, L. J., Tyhan, P. W., Warner, J. R., and Stanley, E. R., 1982, Survival of mononuclear phagocytes depends on a lineage-specific growth factor that the differentiated cells selectively destroy, Cell 28: 71–81.

    Article  PubMed  CAS  Google Scholar 

  • Van Furth, R., Kramps, J. A., and Diesselhoff-Den Dulk, M. M. C., 1983, Synthesis of a -antitrypsin by human monocytes, Clin. Exp. Immunol. 51: 551–557.

    PubMed  Google Scholar 

  • Vassalli, J-D., Hamilton, J., and Reich, E., 1977, Macrophage plasminogen activator: Induction by concanavalin A and phorbol myristate acetate, Cell 11: 695–705.

    Article  PubMed  CAS  Google Scholar 

  • Villiger, B., Kelley, D. G., Engleman, W., Kuhn, C. III, and McDonald, J. A., 1981, Human alveolar macrophage fibronectin: Synthesis, secretion, and ultrastructural localization during gelatin-coated latex particle binding, J. Cell. Biol. 90: 711–720.

    Article  PubMed  CAS  Google Scholar 

  • Wahl, L. M., Olsen, C. E., Sandberg, A. L., and Mergenhagen, S. E., 1977, Prostaglandin regulation of macrophage collagenase production, Proc. Natl. Acad. Sci. USA 74: 4955–4958.

    Article  PubMed  CAS  Google Scholar 

  • Whaley, K., 1980, Biosynthesis of the complement components and the regulatory proteins of the alternative complement pathway by human peripheral blood monocytes, J. Exp. Med. 151: 501–516.

    Article  PubMed  CAS  Google Scholar 

  • White, R., Janoff, A., and Godfrey, H. P., 1980, Secretion of alpha-2-macroglobulin by human alveolar macrophages, Lung 158: 9–14.

    Article  PubMed  CAS  Google Scholar 

  • White, R., Leed, D., Habicht, G. S., and Janoff, A., 198la, Secretion of alpha, -proteinase inhibitor by cultured rat alveolar macrophages, Am. Rev. Respir. Dis. 123: 447–449.

    Google Scholar 

  • White, R., Habicht, G., S., Godfrey, H. P., Janoff, A., Barton, E., and Fox, C., 1981b, Secretion of elastase and alpha-2-macroglobulin by cultured murine peritoneal macrophages: studies on their interaction, J. Lab. Clin. Med. 97: 718–729.

    PubMed  CAS  Google Scholar 

  • Wyatt, H. V., Colten, H. R., and Borsos, T., 1972, Production of the second and fourth components of guinea pig complement by single peritoneal cells: Evidence that one cell may produce both components, J. Immunol. 108: 1609–1614

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department Immunology and Inflammation, Merck Sharp & Dohme Research Laboratories, Rahway, New Jersey, 07065, USA

    Robert J. Bonney & Philip Davies

Authors
  1. Robert J. Bonney
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Philip Davies
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Department of Pathology and Microbiology-Immunology, Duke University Medical Center, 27710, Durham, North Carolina, USA

    Dolph O. Adams

  2. Litton Institute of Applied Biotechnology, Rockville, Maryland, USA

    Michael G. Hanna Jr.

Rights and permissions

Reprints and permissions

Copyright information

© 1984 Springer Science+Business Media New York

About this chapter

Cite this chapter

Bonney, R.J., Davies, P. (1984). Possible Autoregulatory Functions of the Secretory Products of Mononuclear Phagocytes. In: Adams, D.O., Hanna, M.G. (eds) Macrophage Activation. Contemporary Topics in Immunobiology, vol 13. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-1445-6_10

Download citation

  • DOI: https://doi.org/10.1007/978-1-4757-1445-6_10

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4757-1447-0

  • Online ISBN: 978-1-4757-1445-6

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation