Effects of Benzofuran Derivatives on Tubular Permeability to Urate-2-14C in the Rat Nephron
It is generally admitted that renal excretion of urate may involve a three component system: glomerular filtration and tubular reabsorption and/or secretion (1). Tubular microinjection experiments in the rat kidney showed that urate was essentially reabsorbed along the proximal tubule presumably by a carrier-mediated mechanism. Under these experimental conditions a secretory process for urate could not be shown nor excluded (2). In an attempt to further unravel some of the uncertainties related to these transport mechanisms we have investigated the effects of benzofuranne derivatives on urate transport along the rat nephron. Rats were pretreated with benzbromarone or benziodarone which are two potent uricosuric drugs in man (3,4).
KeywordsProximal Tubule Distal Tubule Urate Transport Micropuncture Study Benzofuran Derivative
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