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Uric Acid Excretion in Infancy

  • J. Passwell
  • S. Orda
  • M. Brish
  • H. Boichis
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 41 B)

Abstract

Studies of the various renal functions in infants have enabled pediatricians to understand their limited capacity to maintain homeostasis. The neonatal glomerular filtration rate is twenty percent of the normal value when corrected for surface area and tubular immaturity is at an even lower functional level than the glomerulus as evident by a lowered renal threshold of bicarbonate and amino acids, a decreased Tm of glucose and a decreased tubular reabsorption of phosphate (1). The morphological factors for this relatively increased tubular immaturity are the increased surface area of glomerular tissue as compared to tubular tissue and the presence of anatomic heterogeneity especially of the tubules. With increasing age the renal growth increases so that the ratio of kidney size to surface area becomes constant. This increase in kidney mass is largely due to the increased growth of the proximal tubules (2). This is an important factor explaining the relative glomerular tubular preponderance of the foetus and newborn.

Keywords

Fractional Excretion Acid Excretion Tubular Reabsorption Kidney Size Uric Acid Excretion 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Edelmann CM., and Spitzer A.: The Maturing Kidney. J. of Pediat. 75:509, 1969.CrossRefGoogle Scholar
  2. 2.
    Fetterman G.H., Shuplock N.A., Philipp F.S., and Gregg H.S.: The Growth and Maturation of Human Glomeruli and Proximal Convolutions from Term to Adulthood. Studies by Microdissection. Pediatrics 35:601, 1965.Google Scholar
  3. 3.
    Marks J.F., Kay J., Baum J., Curry L.,: Uric Acid Levels in Full Term and Low-Birth-Weight Infants. J. of Pediatrics 73:609–611, 1968.CrossRefGoogle Scholar
  4. 4.
    Steel T.H.: Control of Uric Acid Excretion. New Eng. J. Med. 284: 1193, 1971.CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1974

Authors and Affiliations

  • J. Passwell
    • 1
  • S. Orda
    • 1
  • M. Brish
    • 1
  • H. Boichis
    • 1
  1. 1.Pediatric Renal Unit and Dept. of NeonatologyThe Chaim Sheba Medical CenterTel-HashomerIsrael

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