Evidence for a Post-Secretory Reabsorptive Site for Uric Acid in Man
Urinary uric acid is thought to be derived from two sources: uric acid filtered at the glomerulus and incompletely reabsorbed, and uric acid secreted by the renal tubules. The magnitude of the decrease in urinary uric acid which follows administration of pyrazinamide has been widely accepted as an estimate of the secretory component of urinary uric acid. This estimate is dependent upon the assumption that the site of uric acid reabsorption in the renal tubule is proximal to the site of its secretion. Recently, we have reported that total urinary uric acid excretion increases when urine flow rate increases, and have suggested that this was the result of decreased distal tubular reabsorption of uric acid.
KeywordsLactate Aspirin Purine Salicylate Verse
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