Suppression of Uric Acid Secretion in a Patient with Renal Hypouricemia
Despite much recent progress, we remain uncertain as to the precise mechanisms of uric acid excretion and the actions of interfering drugs. We have explored these questions with the assistance of an unusual individual with renal hypouricemia. Our patient is an essentially normal 55 year old woman who first consulted Dr. Skeith for low grade hypertension and mild obesity. Physical examination and laboratory evaluation are otherwise normal with no evidence of aminoaciduria or renal glycosuria. She consistently, however, has been found to have a serum urate level of 0.3 mg/% while her total uric acid excretion is within normal limits. Expressed in the conventional terms of renal physiology, this woman has a clearance of urate which consistently exceeds her glomerular filtration rate. In this respect, she resembles only two other reported humans, although the same property has long been recognized in Dalmatian dogs.
KeywordsTubular Secretion Creatinine Ratio Sodium Salicylate Serum Urate Level Clearance Ratio
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