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The Pig as an Animal Model for Purine Metabolic Studies

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Book cover Purine Metabolism in Man

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 41))

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Abstract

Small laboratory rodents have many disadvantages for the study of purine metabolism in relation to human disease. They normally pass their purine metabolites in much smaller volumes of urine both in relation to bodyweight and filtration rate (1); in addition, the distribution of enzymes of purine catabolism in these species differs from man (2,3). The pig in contrast has a kidney which structurally and functionally resembles human kidneys closely (4,5), and the distribution of xanthine oxidase and guanase is similar to man (2,3). Because of these advantages, and the finding of “guanine gout” in pigs (6), we studied purine metabolism in this animal (7). The pig has proved a much better model.

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References

  1. Hitchings, G.H. (1966). Ann. Rheum. Dis., 25, 601.

    Article  CAS  Google Scholar 

  2. Al-Khalidi, U.A.S., Chaglassian, T.H. (1965). Biochem. J., 97, 318.

    Article  CAS  Google Scholar 

  3. Levine, R., Hall, T.C., Harris, C.A. (1963). Cancer, 16, 269.

    Article  CAS  Google Scholar 

  4. Nielsen, T.W., Maaske, C.A., Booth, N.H. (1966). In: Swine in Biochemical Research, Bustad, L.K., McLellan, R.O. (Eds). Bartel Memorial Trust, p.529.

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  5. Farebrother, D.A., Hatfield, P.J., Simmonds, H.A., Cameron, J.S., Jones, A.S., Cadenhead, A. In preparation.

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  6. Virchow, R. (1866). Virchow’s Arch. Path. Anat. Physiol., 35, 358.

    Article  Google Scholar 

  7. Simmonds, H.A., Hatfield, P.J., Cameron, J.S., Jones, A.S., Cadenhead, A. (1973). Biochem. Pharmacol. In press.

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  8. Simmonds, H.A., Rising, T.J., Cadenhead, A., Hatfield, P.J., Jones, A.S., Cameron, J.S. (1973). Biochem. Pharmacol. In press.

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  9. Elion, G.B., Kovensky, A., Hitchings, G.H., Metz, E., Ründles, R.W. (1966). Biochem. Pharmacol., 15, 863.

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Guy’s Hospital and Rowett Research Institute, London, S.E.l 9Rt, UK

    J. S. Cameron, H. A. Simmonds, P. J. Hatfield, A. S. Jones & A. Cadenhead

  2. Guy’s Hospital and Rowett Research Institute, Bucksburn, Aberdeenshire, UK

    J. S. Cameron, H. A. Simmonds, P. J. Hatfield, A. S. Jones & A. Cadenhead

Authors
  1. J. S. Cameron
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  2. H. A. Simmonds
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  3. P. J. Hatfield
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  4. A. S. Jones
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  5. A. Cadenhead
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Editor information

Editors and Affiliations

  1. Division of Metabolic Disease, Rogoff-Wellcome Medical Research Institute, Beilinson Hospital, Petah-Tikva, Israel

    Oded Sperling  & Andre De Vries  & 

  2. Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA

    James B. Wyngaarden

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© 1974 Springer Science+Business Media New York

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Cameron, J.S., Simmonds, H.A., Hatfield, P.J., Jones, A.S., Cadenhead, A. (1974). The Pig as an Animal Model for Purine Metabolic Studies. In: Sperling, O., De Vries, A., Wyngaarden, J.B. (eds) Purine Metabolism in Man. Advances in Experimental Medicine and Biology, vol 41. Springer, New York, NY. https://doi.org/10.1007/978-1-4757-1433-3_41

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  • DOI: https://doi.org/10.1007/978-1-4757-1433-3_41

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  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4757-1435-7

  • Online ISBN: 978-1-4757-1433-3

  • eBook Packages: Springer Book Archive

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