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Urinary Excretion of 6 Hydroxylated Metabolite and Oxypurines in a Xanthinuric Man Given Allopurinol or Thiopurinol

  • C. Auscher
  • C. Pasquier
  • N. Mercier
  • F. Delbarre
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 41 B)

Abstract

Xanthinuria is characterized by a large urinary excretion of oxypurine (xanthine + hypoxanthine) which replaces uric acid at the end product of purine metabolism. Patients with xanthinuria are very deficient in xanthine oxidase activity. This rare metabolic disorder may be of interest for both information: 1) the contribution of xanthine oxidase in the 6 hydroxylation of 4-hydroxy-pyrazolo (3,4-d) pyrimidine [(Pyrazolo (3,4-d) pyrimidine = PP)]: allopurinol and 4-thio-pyrazolo (3,4-d) pyrimidine: thiopurinol. 2) the contribution of their nucleotides (allo and thiopurinol ribonucleotide) to the reduction of biosynthesis de novo of purine.

Keywords

Urinary Excretion Xanthine Oxidase Normal Renal Function Purine Metabolism Xanthine Oxidase Activity 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1974

Authors and Affiliations

  • C. Auscher
    • 1
  • C. Pasquier
    • 1
  • N. Mercier
    • 1
  • F. Delbarre
    • 1
  1. 1.Centre de Recherches sur les Maladies Ostéo-articulairesUnité no5 INSERM. ERA 337 CNRS. Clinique de Rhumatologie Médicale et Sociale Hôpital CochinParisFrance

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