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Effects of Allopurinol and Oxonic Acid on Pyrimidine Metabolism in the Pig

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Purine Metabolism in Man

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 41))

Abstract

Pigs given allopurinol showed an increase in urinary orotic acid and orotidine excretion from a mean of 5 mg to a mean of 50 mg/24 hours. Although the dose of allopurinol was constant the levels of orotic acid and orotidine fell gradually from their initial peak. When the drug was stopped levels returned rapidly to normal. These results are similar to those obtained in rat and man (1), where this effect has been attributed to inhibition of the enzyme orotidylic decarboxylase (2).

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References

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Authors and Affiliations

  1. Guy’s Hospital and Rowett Research Institute, London, S.E.l 9Rt, UK

    P. J. Hatfield, H. A. Simmonds, J. S. Cameron, A. S. Jones & A. Cadenhead

  2. Guy’s Hospital and Rowett Research Institute, Bucksburn, Aberdeenshire, UK

    P. J. Hatfield, H. A. Simmonds, J. S. Cameron, A. S. Jones & A. Cadenhead

Authors
  1. P. J. Hatfield
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  2. H. A. Simmonds
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  3. J. S. Cameron
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  4. A. S. Jones
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  5. A. Cadenhead
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Editor information

Editors and Affiliations

  1. Division of Metabolic Disease, Rogoff-Wellcome Medical Research Institute, Beilinson Hospital, Petah-Tikva, Israel

    Oded Sperling  & Andre De Vries  & 

  2. Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA

    James B. Wyngaarden

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© 1974 Springer Science+Business Media New York

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Hatfield, P.J., Simmonds, H.A., Cameron, J.S., Jones, A.S., Cadenhead, A. (1974). Effects of Allopurinol and Oxonic Acid on Pyrimidine Metabolism in the Pig. In: Sperling, O., De Vries, A., Wyngaarden, J.B. (eds) Purine Metabolism in Man. Advances in Experimental Medicine and Biology, vol 41. Springer, New York, NY. https://doi.org/10.1007/978-1-4757-1433-3_33

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  • DOI: https://doi.org/10.1007/978-1-4757-1433-3_33

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  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4757-1435-7

  • Online ISBN: 978-1-4757-1433-3

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