Metabolic Studies of Thiopurinol in Man and the Pig
Thiopurinol (mercapto-4-pyrazolo (3,4-d) pyrimidine) differs in structure from Allopurinol only by the substitution of a SH (thiol) group for an OH group on the 4-carbon atom. Delbarre and co-workers in 1968 drew attention to the fact that Thiopurinol is a potent inhibitor of uric acid synthesis, comparable in efficiency to Allopurinol. In their series of 56 patients suffering from gout, Thiopurinol was found to be clinically effective and generally well tolerated. A striking finding was that the fall in plasma and urine uric acid levels was not accompanied by a rise in the corresponding levels of xanthine and hypo-xanthine, suggesting that xanthine oxidase inhibition was not the predominating mechanism. These findings were confirmed by Serre and co-workers who treated 50 patients with gout satisfactorily.
KeywordsMetabolic Study Gouty Arthritis Purine Metabolism Orotic Acid Xanthine Oxidase Inhibition
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