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Metabolic Studies of Thiopurinol in Man and the Pig

  • R. Grahame
  • H. A. Simmonds
  • A. Cadenhead
  • B. M. Dean
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 41 B)

Abstract

Thiopurinol (mercapto-4-pyrazolo (3,4-d) pyrimidine) differs in structure from Allopurinol only by the substitution of a SH (thiol) group for an OH group on the 4-carbon atom. Delbarre and co-workers in 1968 drew attention to the fact that Thiopurinol is a potent inhibitor of uric acid synthesis, comparable in efficiency to Allopurinol. In their series of 56 patients suffering from gout, Thiopurinol was found to be clinically effective and generally well tolerated. A striking finding was that the fall in plasma and urine uric acid levels was not accompanied by a rise in the corresponding levels of xanthine and hypo-xanthine, suggesting that xanthine oxidase inhibition was not the predominating mechanism. These findings were confirmed by Serre and co-workers who treated 50 patients with gout satisfactorily.

Keywords

Metabolic Study Gouty Arthritis Purine Metabolism Orotic Acid Xanthine Oxidase Inhibition 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1974

Authors and Affiliations

  • R. Grahame
    • 1
    • 2
  • H. A. Simmonds
    • 1
    • 2
  • A. Cadenhead
    • 1
    • 2
  • B. M. Dean
    • 1
    • 2
  1. 1.Departments of Rheumatology and Medicine, Guy’s Hospital and Professorial Medical UnitSt. Bartholomew’s HospitalLondonUK
  2. 2.Rowett Research InstituteAberdeenUK

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