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The Binding of Urate to Plasma Proteins

  • James R. Klinenberg
  • Rodney Bluestone
  • David Campion
  • Michael Whitehouse
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 41 B)

Abstract

Although the etiologic role of microcrystalline monosodium urate monohydrate in the pathogenesis of acute gouty arthritis has been well established, the mechanism by which urate precipitates in joints, soft tissues and the kidneys remains unclear. Some studies have suggested that the solubility of urate is the key factor and that when the solubility of urate in blood synovial fluid and urine is exceeded, urate then precipitates. The question is more complex than this, however, since only approximately 25 per cent of patients with hyperuricemia develop acute gouty arthritis. Furthermore, there is poor correlation between uric acid concentration and the frequency of acute gouty attacks. This has led to speculation that there are factors in serum which are partially responsible for solubilization of urate and that alterations in these factors could be responsible for urate deposition.

Keywords

Plasma Protein Human Serum Albumin Equilibrium Dialysis Tophaceous Gout Acute Gouty Arthritis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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Copyright information

© Springer Science+Business Media New York 1974

Authors and Affiliations

  • James R. Klinenberg
    • 1
  • Rodney Bluestone
    • 2
  • David Campion
    • 3
  • Michael Whitehouse
    • 3
  1. 1.Depts. Med.Cedars-Sinai Med. Ctr. & UCLA Sch. of Med.Los AngelesUSA
  2. 2.Med. Serv.VA-Wadsworth Hosp. Ctr.Los AngelesUSA
  3. 3.Dept. of Med.UCLA Sch. of Med.Los AngelesUSA

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