An Integrative Hypothesis for the Renal Disease of Urate Overproduction
In patients with both gouty arthritis and renal disease, it may be difficult to determine whether the gout followed the renal disease or the renal disease was secondary to the hyperuricaemia and gout. However, in genetic overproducers of urate, the abnormality of urate metabolism has been present from birth and is the primary abnormality. Renal disease in such subjects is most likely to be secondary to this metabolic abnormality. Thus, a study of kidney disease in patients with HGPRTase deficiency should give useful information concerning renal damage due to uric acid, especially as the study of Talbott and Terplan (1) concerning renal disease in gout showed uric acid crystals to be an almost constant finding.
KeywordsUrine Volume Renal Colic Gouty Arthritis Calculus Formation Uric Acid Crystal
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- 1.Talbott, J.H. and Terplan, K.L. (1960). The kidney in gout. Medicine (Baltimore) 39: 405.Google Scholar