Metabolic and Glucose Load Studies in Uric Acid, Oxalic and Hyperparathyroid Stone Formers

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 41)


There is as yet little knowledge about the metabolic origin of idiopathic hypercalciuria (HC) and associated hyperuricosuria frequently accompanied by formation of calcium containing renal stones. Following a carbohydrate-rich meal, in 1969 Lemann and coworkers (1) observed higher urinary calcium in oxalic stone formers and their relatives than in healthy controls. Endogenous resistance to insulin and its consecutive overproduction was recently reported from patients with primary hyperparathyroidism (2), and a marked loss of insulin via urine was objectived by Ching and his group (3) in patients producing calcium stones. They failed to find disturbed glucose tolerance, but their data gave no information as to the amount of glucose administered. In earlier studies (unpublished) undertaken to screen stone people by oral glucose load (100g) we found pathological plasma glucose (2 hours) in a rather great number of stone patients without symptoms of diabetes and /or overt obesity. Also there was apparently no relation to either sex or age or, most important, the type of stone, i.e. oxalic or uric acid.


Uric Acid Primary Hyperparathyroidism Glucose Load Renal Stone Calcium Oxalate 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Lemann, J., Piering, W.F. and E.J. Lennon: Possible role of carbohydrate induced calciuria in calcium oxalate kidney stone formation; N.Engl. J.Med. 280, 232, 1969.CrossRefGoogle Scholar
  2. 2.
    Kim, H., Kalkhoff, R.K., Costrini, N.V., Cerletty, J.M. and M. Jacobson: Plasma insulin disturbances in primary hyperparathyroidism; J. Clin. Invest. 50, 259, 1971.CrossRefGoogle Scholar
  3. 3.
    Ching, K.N., Karam, J.H., Choy, F.B., Kolb, O.F., Grodsky, G.M. and P.H. Forsham: Hyperinsulinuria in patients with renal calcium stones; Clin. Chim. Acta 40, 383, 1972.CrossRefGoogle Scholar
  4. 4.
    Pullman, T.N., Lavender, A.R. and H. Aho: Direct effects of glucagon on renal haemodynamics and excretion of inorganic ions; Metabolism 16, 358, 1967.CrossRefGoogle Scholar
  5. 5.
    Schwille, P.O. and B. Barth: Clearance and stop flow studies in glucagon mediated hyperelectrolyturia; Acta endocr. Suppl. 159, 207, 1972.Google Scholar
  6. 6.
    Aguilar-Parada, E., Eisentraut, A.M. and R.H. Unger: Pancreatic glucagon secretion in normal and diabetic subjects; Am. J. Med. Sci. 257, 415, 1969.CrossRefGoogle Scholar
  7. 7.
    Schwille, P.O.: Urinary acid base parameters in stone formers; Renal Stone Symposium, Bonn, 1972 (in press).Google Scholar
  8. 8.
    Gutman, R.A., Fink, G., Voyles, N., Selawry, H. Penkos, J. C., Lepp, A. and L. Recant: Specific biologic effects of intestinal glucagon-like materials; J. Clin. Invest. 52, 1165, 1973.CrossRefGoogle Scholar
  9. 9.
    Schwille, P.O., Jügelt, U. and A. Sigel: Allopurinolabhängige Elektrolyt-und Stoffwechseländerungen im Urin von Nierensteinkranken; Urologe A 11, 185, 1972.PubMedGoogle Scholar
  10. 10.
    Coe, F.L. and L. Raisen: Allopurinol treatment of uric acid disorders in calcium stone formers; Lancet January 20, 129, 1973.CrossRefGoogle Scholar
  11. 11.
    Hoffman, R.S., Martino, J.A., Wahl, G. and R.A. Arky: Fasting and refeeding. III. Antinatriuretic effect of oral and intravenous carbohydrate and its relationship to potassium excretion; Metabolism 20, 1065, 1971.CrossRefGoogle Scholar
  12. 12.
    Frey, H.M.M., Falch, D., Forfang, K., Norman, N. and D. Fremstad: effects of long term infusion of glucagon on carbohydrate metabolism, insulin and growth hormone secretion in patients with congestive heart failure; Diabetes 21, 939, 1972.CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1974

Authors and Affiliations

  1. 1.Hormone and Metabolism Laboratory, Department of Surgery and Urology, Faculty of MedicineUniversity of Erlangen-NuernbergGermany

Personalised recommendations