Observations of Altered Intracellular Phosphoribosylpyrophosphate (PP-Ribose-P) in Human Disease
An intricate system of interrelated control mechanisms regulate biochemical reaction sequences. Metabolic pathways are controlled not only by specific activity and inherent kinetic properties of enzymes in the pathway but also by the intracellular concentration of certain essential substrates, activators or inhibitors. PP-ribose-P is an essential substrate of purine, pyrimidine and pyridine biosynthesis. The intracellular concentration of PP-ribose-P represents a balance between its synthesis by PP-ribose-P synthetase and its utilization which is catalyzed by several different phosphoribosyltransferase (PRT) enzymes as well as non-specific phosphatases. Alterations in the rate of synthesis or degradation of PP-ribose-P, whether drug induced or secondary to an inborn error, could potentially change the intracellular concentration of this compound.
KeywordsPhosphorus Pyridine Anemia Glutamine Adenine
Unable to display preview. Download preview PDF.
- Fox, I. H. and Kelley, W. N. 1971. Phophoribosylpyrophosphate in man: Biochemical and clinical signficiance. 74: 424–433.Google Scholar
- Greene, M. L. and Seegmiller, J. E. 1969. Erythrocyte 5-phosphoribosyl-1-pyrophosphate (PRPP) in gout: Importance of PRPP in the regulation of human purine synthesis (Abstract). Arth. Rheum. 12: 666–667.Google Scholar
- Valentine, W. N., Anderson, H. M., Paglia, D. E., Jaffe, E. R., Konrad, P. N. and Harris, S. R. 1972. Studies on human erythrocyte nucleotide metabolism. II. Nonspherocytic hemolytic anemia, high red cell ATP and ribosephosphate phosphoribokinase (Rpk, E.C. 184.108.40.206) deficiency. Blood. 39: 674–684.PubMedGoogle Scholar