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A Comparison of Behavioral and Neurochemical Effects on Ethanol and Chlordiazepoxide

  • G. D. Frye
  • R. A. Vogel
  • R. B. Mailman
  • M. G. Ondrusek
  • J. H. Wilson
  • P. A. Mueller
  • G. R. Breese

Abstract

Many similarities were observed in the behavioral and neurochemical actions of ethanol and chlordiazepoxide (CDZ) suggesting that these agents may share common mechanisms of action. However, similarities in these actions could not be explained by effects on a benzodiazepine binding site, since only CDZ interacted with this locus.

Keywords

Locomotor Activity Chronic Ethanol Alcohol Withdrawal Syndrome aUdiogenic Seizure Ethanol Withdrawal 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1980

Authors and Affiliations

  • G. D. Frye
    • 1
  • R. A. Vogel
    • 1
  • R. B. Mailman
    • 1
  • M. G. Ondrusek
    • 1
  • J. H. Wilson
    • 1
  • P. A. Mueller
    • 1
  • G. R. Breese
    • 1
  1. 1.Center for Alcohol Studies, Biological Sciences Res. Ctr., Depts. of Psychiatry, Pharmacology and AnethesiologyUniv. of N.C. School of MedicineChapel HillUSA

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