Genetic Regulation of Alcohol Dehydrogenase, Aldehyde Dehydrogenase and Aldehyde Oxidase Isozymes in the Mouse

  • Roger S. Holmes


Electrophoretic and activity variants for the C2 isozyme of alcohol dehydrogenase (ADH-C2), the mitochondrial isozyme of aldehyde dehydrogenase (AHD-A2) and aldehyde oxidase isozymes (AOX-l; AOX-2) in inbred strains of Mus musculus were used to map the genes encoding these enzymes on the mouse genome. Adh-3 (encoding ADH-C2) was local ized on chromosome 3 and was closely linked to a cis-acting regulator locus (Adh-3-t), which determined ADH-C2 activity in male reproductive tissues. Ahd-1 (encoding AHD-A2) was found on chromosome 4 near Gpd-1 (encoding the liver isozyme of glucose-6-phosphate dehydrogenase), whereas the aldehyde oxidase loci (Aox-1, Aox-2) were closely linked on chromosome 1 near Id-1 (encoding isocitrate dehydrogenase).


Inbred Strain Aldehyde Dehydrogenase Aldehyde Oxidase Codominant Allele Female Reproductive Tissue 
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Copyright information

© Springer Science+Business Media New York 1980

Authors and Affiliations

  • Roger S. Holmes
    • 1
  1. 1.School of ScienceGriffith UniversityNathanAustralia

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