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Dependence of Mitochondrial and Cytosolic ATP Systems on the Metabolic State of Perfused Rat Liver

  • Roland Scholz
  • Sibylle Soboll
  • Hans Walter Heldt

Abstract

Adenine nucleotides are the link between energy generating and energy utilizing processes in the cell. ATP is generated mainly in the mitochondria and is utilized mainly in the cytosol. It is transported across the mitochondrial membrane by a specific carrier in exchange for ADP. Since ATP and ADP are substrates and products of many reactions, most metabolic processes depend upon the phosphorylation potentials of the subcellular adenine nucleotide system. Moreover, ATP and ADP also act as modulators of several regulatory enzymes. A knowledge of their subcellular concentrations or phosphorylation potentials as reflected largely by the ATP/ADP ratios, therefore, will certainly increase our understanding of how metabolism is regulated in the living cell.

Keywords

Adenine Nucleotide Adenine Nucleotide Translocation Uncouple Agent Aldehyde Metabolize Cytosolic Phosphorylation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Elbers, R., H.W. Heldt, P. Schmucker, S. Soboll, and H. Wiese, 1974, Measurement of the ATP/ADP ratio in mitochondria and in the extramitochondrial compartment by fractionation of freeze stopped liver tissue in non-aqueous media, Hoppe-Seyler’s Z. Physiol. Chem. 355: 378.Google Scholar
  2. Soboll, S., 1977, Metabolitkonzentrationen im mitochondrialen und cytosolischen Jompartiment der Leber als Funktion des Stoff-wechselzustandes, Thesis, Technische Universität Munchen..Google Scholar
  3. Soboll, S., R. Scholz, and H.W. Heldt, 1978, Subcellular metabolite concentrations: Dependence of mitochondrial and cytosolic ATP systems on the metabolic state of perfused rat liver, Eur. J. Biochem. 87: 377.Google Scholar
  4. Thurman, R.G., and R. Scholz, 1977,Interaction of glycolysis and respiration in perfused rat liver: Changes in oxygen uptake following the addition of ethanol, Eur. J. Biochem. 75:13Google Scholar

Copyright information

© Springer Science+Business Media New York 1980

Authors and Affiliations

  • Roland Scholz
    • 1
  • Sibylle Soboll
    • 1
  • Hans Walter Heldt
    • 1
  1. 1.Institut für Physiologische Chemie, Physikalische Biochemie und ZellbiologieUniversität MünchenMünchen 2Deutschland

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