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Isozymes of Alcohol Dehydrogenase and Aldehyde Dehydrogenase in Japanese and their Role in Alcohol Sensitivity

  • Shoji Harada
  • Dharam P. Agarwal
  • H. Werner Goedde

Abstract

Racial differences in alcohol sensitivity have been described by many authors (Wolff, 1973; Ewing et al., 1974). Variant forms of alcohol metabolizing enzymes have been proposed to play an important role in sensitivity to alcohol associated with facial flushing and other subjective symptoms (Stamatoyannopoulos et al., 1975; Goedde et al., 1979b; Harada et al., 1979).

Keywords

Hair Root Isozyme Pattern Facial Flushing Alcohol Sensitivity Scalp Skin 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Agarwal, D.P., S. Harada, I. Willers, and H.W. Goedde, 1978, Human alcohol dehydrogenase and aldehyde dehydrogenase isozymes in cultured fibroblasts and tissues, Arch. Genet., 51: 1.Google Scholar
  2. Asmussen, E., J. Hald, and V. Larsen, 1948, The pharmacological action of acetaldehyde on the human organism, Acta. Pharmacol. Toxicol., 4: 311.CrossRefGoogle Scholar
  3. Edwards, J.A., and E. Evans, 1967, Ethanol metabolism in subjects possessing typical and atypical liver alcohol dehydrogenase, Clin. Pharmacol. Ther., 8: 824.PubMedGoogle Scholar
  4. Ewing, J.A., B.A. Rouse, and E.D. Pellizari, 1974, Alcohol sensitivity and ethnic background, Am. J. Psychiatry, 131: 206.PubMedGoogle Scholar
  5. Goedde, H.W., D.P. Agarwal, S. Harada, 1979a, Alcohol metabolizing enzymes: Studies of isozymes-in human biopsies and cultured fibroblasts, Clin. Genet., 16: 29.PubMedCrossRefGoogle Scholar
  6. Goedde, ‘H.W., S. Harada, and D.P. Agarwal, 1979b, Racial difference in alcohol sensitivity: A new hypothesis, Hum. Genet., 51: 331.PubMedCrossRefGoogle Scholar
  7. Greenfield, N.J., and R. Pietruszko, 1977, Two aldehyde dehydrogenases from human liver. Isolation via affinity chromatography and characterization of the isozymes, Biochim. Biophys. Acta, 483: 35.PubMedCrossRefGoogle Scholar
  8. Harada, S., D.P. Agarwal, and H.W. Goedde, 1978a, Application of gel isoelectric focusing and electrophoresis in the study of alcohol dehydrogenase and aldehyde dehydrogenase isozymes of human tissues and fibroblasts, in: “Electrophoresis 78”, Catsimpoolas, ed., Elsevier North Holland, Inc., NY.Google Scholar
  9. Harada, S., D.P. Agarwal, and H.W. Goedde, 1978b, Human liver alcohol dehydrogenase isozyme variation: Improved separation methods using prolonged high voltage starch gel electrophoresis and isoelectric focusing, Hum. Genet., 40: 215.PubMedCrossRefGoogle Scholar
  10. Harada, S., D.P. Agarwal, and H.W. Goedde, 1978c4 Isozyme variations in acetaldehyde dehydrogenase (E.C. 1.2.1.3) in human tissues, Hum. Genet., 44: 181.Google Scholar
  11. Harada, S., S. Misawa, D.P. Agarwal, and H.W. Goedde, 1980, Liver alcohol dehydrogenase and aldehyde dehydrogenase in Japanese: Isozyme variation and its possible role in alcohol intoxication, Am. J. Human Genet. in press.Google Scholar
  12. Ijiri, I., 1974, Studies on the relationship between the concentrations of blood acetaldehyde and urinary catecholamine and the symptoms after drinking alcohol, Jap. J. Stud. Alcohol, 9: 35.Google Scholar
  13. Mizoi, Y., I. Ijiri, Y. Tatsuno, T. Kijima, S. Fujiwara, T. Adachi, and S. Hshida, 1979, Relationship between facial flushing and blood acetaldehyde levels after alcohol intake, Pharmacol. Biochem. Behay., 10: 303.CrossRefGoogle Scholar
  14. Schulz, W., S. Kreuzberg, H.G. Neymeyer, U. Schwarz, and P. Pachaly, 1976, Uber die Hayfigkeit der atypischen ADH in Leberbiopsie-material und den Einflub auf den Athanolumsatz in vivo, Kriminalistik und forensische Wissenschaften, 26: 109.Google Scholar
  15. Smith, M., D.A. Hopkinson, and H. Harris, 1973, Studies on the properties of the human alcohol dehydrogenase isozymes determined by the different loci ADH1, ADH2, and ADH3, Ann. Hum. Genet., 37: 49.PubMedCrossRefGoogle Scholar
  16. Stamatoyannopoulos, G., S.H. Chen, and F. Fukui, 1975, Liver alcohol dehydrbgenase in Japanese: High population frequency of atypical form and its possible role in alcohol sensitivity, Am. J. Hum. Genet., 27: 789.PubMedGoogle Scholar
  17. Von Wartburg, J.P., J. Papenberg, and H. Aebi, 1965, An atypical human alcohol dehydrogenase, Can. J. Biochem. 43:889.Google Scholar
  18. Wolff, P.H., 1973, Vasmotor sensitivity to alcohol in diverse Mongoloid populations, Am. J. Hum. Genet., 25: 193.PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1980

Authors and Affiliations

  • Shoji Harada
    • 1
  • Dharam P. Agarwal
    • 1
  • H. Werner Goedde
    • 1
  1. 1.Institute of Human GeneticsUniversity of HamburgHamburgWest Germany

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