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A Possible Hemoglobin Marker of Alcoholism

  • Henry D. Hoberman

Abstract

Human erythrocytes were found to synthesize 5-deoxy-D-xylulose1-phosphate from added acetaldehyde and endogenous dihydroxyacetone phosphate. In separate experiments 5-deoxy-D-xylulose-l-phosphate was observed to react with hemoglobin Ao, forming a stable adduct. Formation and accumulation of this unique form of hemoglobin in the blood of alcohol users, by integrating the blood acetaldehyde concentration, would provide a dose-time record of alcohol consumption.

Keywords

Human Erythrocyte Lactate Production Molar Equivalent Triose Phosphate Isomerase Polyacrylic Acid 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1980

Authors and Affiliations

  • Henry D. Hoberman
    • 1
  1. 1.Department of BiochemistryAlbert Einstein College of MedicineBronxUSA

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