A Possible Hemoglobin Marker of Alcoholism

  • Henry D. Hoberman


Human erythrocytes were found to synthesize 5-deoxy-D-xylulose1-phosphate from added acetaldehyde and endogenous dihydroxyacetone phosphate. In separate experiments 5-deoxy-D-xylulose-l-phosphate was observed to react with hemoglobin Ao, forming a stable adduct. Formation and accumulation of this unique form of hemoglobin in the blood of alcohol users, by integrating the blood acetaldehyde concentration, would provide a dose-time record of alcohol consumption.


Human Erythrocyte Lactate Production Molar Equivalent Triose Phosphate Isomerase Polyacrylic Acid 
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  1. Eriksson, S., Fex, G., Johansson, B. and Nilsson, B., 1979, Plasma a-amino-n-butyric acid/leucine ratio in alcoholism, N. Eng. J Med., 300:93.Google Scholar
  2. Gabay, K. H., Hasty, K., Breslow, J. L., Ellison, R. C., Bunn, H. F. and Gallop, P., 1977, Glycolsylated hemoglobins and long-term glucose control in diabetes mellitus, J. Clin. Endocrinol. Metab 44:859.Google Scholar
  3. Hoberman, H. D., 1979a, Synthesis of 5-deoxy-D-xylulose-l-phosphate by human erythrocytes, Biochem. Biophys. Res. Comm 90:757.Google Scholar
  4. Hoberman, H. D., 1979b, Adduct formation between hemoglobin and 5deoxy-D-xylulose-l-phosphate, Biochem. Biophys. Res. Comm 90:764.Google Scholar
  5. Inoue, E., Ohbora, Y. and Yamasawa, K., 1978, Metabolism of acetaldehyde by human erythrocytes, Life Sciences 23: 179.CrossRefGoogle Scholar
  6. Koenig, R. J., Peterson, C. M., Kilo, C., Cerami, A. and Williamson, J. R., 1976, Hemoglobin Alc as an indicator of the degree of glu-close intolerance in diabetes, Diabetes 25: 230.Google Scholar
  7. Kristensson, H., Trell, E., Eriksson, S., Hanik, L. and Hood, B., 1977, Serum y-glutamyl-transferase in alcoholism, Lancet, 1: 609.PubMedCrossRefGoogle Scholar
  8. Meyerhof, O., Lohmann, K. and Schuster, P., 1936, Uber die Aldolase, ein Kohlenstoffverknüpfendes Ferment. 1. Aldolkondensation von Dihydroxyacetonphosphorsaüre mit Acetaldehyde., Biochem Z., 286: 301.Google Scholar
  9. Minakami, S., Suzuki, C., Saito, T. and Yoshikawa, H., 1965, Studies on erythrocyte glycolysis.l. determination of the glycolytic intermediates in human erythrocytes, J. Biochem 58:543.Google Scholar
  10. Morgan, M. Y., Milsom, J. P. and Sherlock, S., 1977, Ratio of plasma a-amino-n-butyric acid to leucine as an empirical marker of alcoholism: diagnostic value, Science 197: 1183.Google Scholar
  11. Rahbar, S., Paulsen, L. and Ranney, H. M., 1969, Studies of hemoglobins in patients with diabetes mellitus, Diabetes 18: 332.Google Scholar
  12. Rollason, J. G., Pincherie, G. and Robinson, D., 1972, Serum gamma glutamyl transpeptidase in relation to alcohol consumption, Clinica Chim. Acta 39:75.Google Scholar
  13. Rose, I. A., 1971, Regulation of human red cell glycolysis: a review, Exp. Eye Res 11: 264.PubMedCrossRefGoogle Scholar
  14. Shaw, S., Stimmel, B. and Lieber, C. S., 1976, Plasma a-amino-nbutyric acid to leucine ratio: an empirical biochemical marker of alcoholism, Science 194: 1057.Google Scholar
  15. Stevens, V. J., Vlassar, H., Abati, A. and Cerami, A., 1977, Nonenzymatic glycosylation of hemoglobin, J Biol. Chem., 252: 2998.Google Scholar
  16. Trivelli, L. A., Ranney, H. M. and Lai, H. T., 1971, Hemoglobin components in patients with diabetes mellitus, N. Eng. J. Med 284:353.Google Scholar
  17. Whitehead, T. P., Clarke, C. A. and Whitfield, A. G. W., 1978, Biochemical and haematological markers of alcohol intake, Lancet 1: 978.Google Scholar

Copyright information

© Springer Science+Business Media New York 1980

Authors and Affiliations

  • Henry D. Hoberman
    • 1
  1. 1.Department of BiochemistryAlbert Einstein College of MedicineBronxUSA

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