The Presence of 2,3-Butanediol in the Blood of Chronic Alcoholics Admitted to an Alcohol Treatment Center

  • Michael E. Felver
  • M. R. Lakshmanan
  • Stewart Wolf
  • Richard L. Veech


Fifty-one of sixty-three unselected alcoholic subjects had 2,3-butanediol in their blood in concentrations ranging from 0.011 to 0.775 mM upon admission to an alcohol detoxification center. The concentration of 2,3-butanediol was below the detection limit of 0.01 mM in twelve non-alcoholic controls. Eighteen hours after admission, second blood samples showed no ethanol in all eleven subjects tested. 2,3-Butanediol levels declined in all of the patients and became undetectable in eight.


Alcoholic Patient Hepatic Coma Thiamine Pyrophosphate Alcoholic Subject Eleven Subject 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Alkonyi, I., E. Bolygo, L. Gyocsi, and D. Szabo, 1976, Studies on the formation of acetoin from acetaldehyde by the pyruvate dehydrogenase complex and its regulation, Eur. J. Biochem., 66: 551.PubMedCrossRefGoogle Scholar
  2. Baker, R.N., A.L. Alenty, and J.F. Zack, Jr., 1969, Simultaneous determination of lower alcohols, acetone, and acetaldehyde in blood by gas chromatography, J. Chrom. Sci., 7: 312.Google Scholar
  3. Coppini, D., and A. Monzani, 1973, Acetonic substances in Lambrusco wine, Riv. Viticolt. Enol., 26: 113.Google Scholar
  4. Dawson, J., R.P. Hullin, and A. Pool, 1954, Variations in the blood levels of acetoin and butane-2:3-diol in normal individuals. and mental patients, J. Ment. Sci., 100: 536.PubMedGoogle Scholar
  5. Dawson, J., and R.P. Hullin, 1954, Metabolism of acetoin. I. The formation and utilization of acetoin and butane-2:3-diol in the decerebrated cat, Biochem. J., 57: 177.Google Scholar
  6. Gabriel, M.A., H. Jabara, and U.A.S. Al-Khalidi, 1971, Metabolism of acetoin in mammalian liver slices and extracts. Inter-conversion with butane-2:3 diol and biacetyl, Biochem. J., 124: 793.Google Scholar
  7. Happold, F.C., and C.P. Spencer, 1952, The bacterial formation of acetylmethylcarbinol and 2:3-butylene glycol, Biochim. et Biophys. Acta, 8: 18.CrossRefGoogle Scholar
  8. Hommes, F.A., A.P. Bruins, J. Dajani-Wielaard, and R. Baarsma, 1979, 2,3-Dihydroxybutane: An unusual compound found in the gas chromatographic analysis of volatile compounds of urine, J. Clin. Chem. Clin. Biochem., 17: 97.Google Scholar
  9. Juni, E., 1952, Mechanisms of formation of acetoin by bacteria. J. Biol. Chem., 195: 715PubMedGoogle Scholar
  10. Marner, O.A., J.A. Montgomery, S.S. Tjoa, J.C. Crawhall, and C.S. Feldkamp, 1978, Profiles in altered metabolism. I. The organic acids accumulating in acute non-diabetic ketoacidosis associated with alcoholism, Biomed. Mass Spectrometry, 5: 287.CrossRefGoogle Scholar
  11. Muraki, H., and H. Masuda, 1976, Enzymatic determination of butane2,3-diol in wines, J. Sci. Food Agric., 27: 345.PubMedCrossRefGoogle Scholar
  12. Rutstein, D.D., and R.L. Veech, 1978, Genetics and addiction to alcohol, New Eng. J. Med., 298: 1140.PubMedCrossRefGoogle Scholar
  13. Schreiber, G., G. Kohlhaw, H.W. Goedde, and H. Holzer, 1963, Die biosynthese von acetoin in schweineherzmuske, Biochem. Z., 339: 83.PubMedGoogle Scholar
  14. Soling, H.D., G. Kohihaw, J. Schnermann, H. Holzer, and W. Creutzfeldt, 1964, Zur bedeutung des acetoins fur die pathogenese des coma hepaticum, Deutsch. Med. Wochenschr., 89: 457.CrossRefGoogle Scholar
  15. Stotz, E., W.W. Westerfeld, and R.L. Berg, 1944, The metabolism of acetaldehyde with acetoin formation, J. Biol. Chem., 154: 41.Google Scholar
  16. Tholen, H., F. Bigler, and H. Staub, 1961, Zur pathogenese des uramiesyndromes. I. Mitt: Der gehalt von acetoin and 2,3butylenglykol im blut uramischer patienten, Pathol. Microbiol., 24: 262Google Scholar
  17. Westerfeld, W.W., 1949, Acetaldehyde disappearance and acetoin formation in vitro, Proc. Soc. Exp. Biol. Med., 71: 28.Google Scholar

Copyright information

© Springer Science+Business Media New York 1980

Authors and Affiliations

  • Michael E. Felver
    • 1
  • M. R. Lakshmanan
    • 1
  • Stewart Wolf
    • 1
    • 2
  • Richard L. Veech
    • 1
  1. 1.Laboratory of MetabolismNational Institute on Alcohol Abuse and AlcoholismRockvilleUSA
  2. 2.Totts Gap InstituteBangorUSA

Personalised recommendations