Advertisement

Structure of Cytochrome c Oxidase

  • R. A. Capaldi
  • L. Prochaska
  • R. Bisson

Abstract

Cytochrome c oxidase or cytochrome c : oxygen oxidoreductase (CH 1.9.3.1) is the terminal oxidase in respiratory metabolism of all aerobic organisms and is responsible for catalyzing the reduction of dioxygen to water in the reaction:
$$ 4{H^ + } + 4{e^ - } + {O_2} \rightleftarrows 2{H_2}O $$
The electrons for this reaction are provided by reduced cytochrome c: the free energy developed is used to promote oxidative phosphorylation and in consequence becomes available to the cell as ATP.

Keywords

Cytochrome Oxidase Copper Atom Intact Mitochondrion Beef Heart Photoaffinity Label 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Bienert, H., R.E. Hansen, and C.R. Hartzell, 1976, Kinetic studies on cytochrome c oxidase by combined EPR and reflectance spectroscopy after rapid freezing, Biochim. Biophys. Acta, 423:339.Google Scholar
  2. Bisson, R., A. Azzi, H. Gutweniger, R. Colonna, C. Montecucco, and A. Zanotti, 1978, Interaction of cytochrome c with cytochrome c oxidase. Photoaffïnity labeling of beef heart cytochrome c oxidase with arylazide-cytochrome c, J. Biol. Chem, 253:1874.Google Scholar
  3. Bisson, R., C. Montecucco, H. Gutweniger, and A. Azzi, 1979, Cytochrome c oxidase subunits in contact with phospholipids. Hydrophobic photolabelling with arylazidophospholipids, J. Biol. Chem., 254:9962.Google Scholar
  4. Briggs, M.M., and R.A. Capaldi, 1977, Near-neighbor relationships of the subunits of cytochrome c oxidase, Biochem., 16; 73.Google Scholar
  5. Briggs, M.M., and R.A. Capaldi, 1978, Crosslinking studies on a cytochrome c-cytochrome c oxidase complex, Biochem. Biophys. Res. Commun., 80:553.Google Scholar
  6. Buse, G., G:.J. Steffens, and G.C.M. Steffens, 1978, Studies on cytochrome c oxidase. III. Relationship of cytochrome oxidase subunits to electron carriers of photophosphorylation, Hoppe Seylers’ Z. Physiol. Chem., 359: 1011.Google Scholar
  7. Capaldi, R.A., R.L. Bell, and T. Branchek, 1977, Changes in order of migration of polypeptides in complex III and cytochrome c oxidase under different conditions of SDS polyacrylamide gel electrophoresis, Biochem. Biophys. Res. Commun., 74:425.Google Scholar
  8. Capaldi, R.A., 1979, Structure of cytochrome c oxidase, in: “Membrane Proteins in Energy Transduction,”’ Capaldi, R.A., ed., Marcel Dekker, New York.Google Scholar
  9. Casey, R.P., M. Thelen, and A. Azzi, 1979, Dicyclohexylcarbodiimide inhibits proton translocation by cytochrome c oxidase, Biochem. Biophys. Res. Commun., 87:1044.Google Scholar
  10. Chance, B., C. Saronio, and J.S. Leigh, 1975, Functional intermediates in the reaction of membrane-bound cytochrome oxidase with oxygen, J. Biol. Chem., 250:9226.Google Scholar
  11. Deatherage, J., R. Henderson, R.A. Capaldi, and S.F. Fuller, 1979, Structure of cytochrome c oxidase from electron microscopy and image reconstruction, submitted for publication.Google Scholar
  12. Dockter, M., A. Steinemann, and A. Schatz, 1978, Mapping of yeast cytochrome c oxidase by fluorescence resonance energy transfer.Google Scholar
  13. Distances between subunit II, heure a, and cytochrome c bound to subunit III, J. Biol. Chem., 253:311.Google Scholar
  14. Downer, N.W., N.C. Robinson, and R.A. Capaldi, 1976, Characterization of a seventh different subunit of beef heart cytochrome c oxidase. Similarities between the beef heart enzyme and that from other species, Biochem., 15: 2930.Google Scholar
  15. Fry, T.G., S.H.P. Chan, and G. Schatz, 1978, Structure and Orientation of cytochrome c oxidase in crystalline membranes, J. Biol. Chem., 253:4389.Google Scholar
  16. Fuller, S.F., R.A. Capaldi, and R. Henderson, 1979, Structure of cytochrome c oxidase in deoxycholate-derived two dimensional crystals, J. Mol. Biol., 134:305.Google Scholar
  17. Gutteridge, S., D.B. Winter, W.J. Bruynickx, and H. Mason, 1977, Localization of a Cu and heure a on cytochrome c oxidase poly-peptide, Biochem., Biophys. Res. Commun., 78: 945.Google Scholar
  18. Henderson, R., R.A. Capaldi, and J.S. Leigh, 1977, Arrangement of cytochrome oxidase molecules in two-dimensional vesicle crystals, J. Mol. Biol., 112:631.Google Scholar
  19. Hochli, L., and C.R. Hackenbrock, 1978, Cytochrome c oxidase from rat liver mitochondria: Purification and characterization, Biochem., 17: 3712.Google Scholar
  20. Keilin, D., 1966, in: “The History of Cell Respiration and Cyto-chrome,” Cambridge University, Cambridge, England.Google Scholar
  21. Krab, K., and M.K.F. Wikstrom, 1978, Proton translocating cytochrome c oxidase in artificial phospholipid vesicles, Biochim. Biophys. Acta, 504:200.Google Scholar
  22. Ludwig, B., N.W. Downer, and R.A. Capaldi, 1979, Labeling of cyto-chrome c oxidase with [35S] diazobenzenesulfonate. Orientation of this electron transfer complex in the inner mitochondrial membrane, Biochem., 18; 1401.Google Scholar
  23. Mackey, L.N., T. Kuwana, and C.R. Hartzell, 1973, Evaluation of the energetics of cytochrome c oxidase in the absence of cytochrome c, FEBS Lett., 36: 326.Google Scholar
  24. Mitchell, P., 1977, A commentary on alternative hypotheses of protonic coupling in the membrane systems catalyzing oxidative and photosynthetic phosphorylation, FEBS Lett., 78: 1.Google Scholar
  25. Palmer, G., G.T. Babcock, and L.E. Vickery, 1976, A model for cytochrome oxidase, Proc. Natl. Acad. Sci. USA, 73: 2206.Google Scholar
  26. Poyton, R.O., and G. Schatz, 1975, Cytochrome c oxidase from Bakers’ yeast. III. Physical characterization of isolated subunits and chemical evidence for two different classes of polypeptides, J. Biol. Chem., 250:752.Google Scholar
  27. Poyton, R.O., and J. Kavanagh, 1976, Regulation of mitochondrial protein synthesis by cytoplasmic proteins, Proc. Nat. Acad. Sci. U.S.A., 73:3947.Google Scholar
  28. Sebald, W., W. Machleidt, and J. Otto, 1973, Products of mitochondrial protein synthesis in neurospora crassa. Determination of equimolar amounts of three products in cytochrome oxidase on the basis of amino-acid analysis, Eur. J. Biochem., 38:311.Google Scholar
  29. Seki, S., H. Hayashi, and T. Oda, 1970, Studies on cytochrome oxidase. I. Fine structure of cytochrome oxidase-rich submitochondrial membrane, Arch. Biochem. Biophys., 138:110.Google Scholar
  30. Sigel, E., and E. Carafoli, 1978, The proton pump of cytochrome c oxidase and its stoichiometry, Eur. J. Biochem., 89:119.Google Scholar
  31. Vanderkooi, J., J.S. Leigh, C.S. Ouen, P. Glatz, and H. Blum, 1978, Geometrical relationships between the cytochrome c-cytochrome oxidase mitochondrial recox pairs, in: “Frontiers of Biological Energetics,” P.L. Dutton, J.S. Leigh, and A. Scarpa, eds., Academic Press, New York.Google Scholar
  32. Wakabayashi, T., A.E. Senior, O. Hatase, H. Hayashi, and D.E. Green, 1972, Conformational changes in membranous preparations of cytochrome oxidase, J. Bioenergetics, 3:339.Google Scholar
  33. Weiss, H., B. Lorenz, and W. Kleinow, 1972, Contribution of mitochondrial protein synthesis to the formation of cytochrome oxidase in locusta migratosia, FEES Lett., 25: 49.Google Scholar
  34. Wikstrom, M.K.F., 1977, Proton pump coupled to cytochrome c oxidase in mitochondria, Nature, 266: 271.Google Scholar
  35. Wikstrom, M.K.F., and H.T. Saari, 1977, The mechanism of energy conservation and transduction by mitochondrial cytochrome c oxidase, Biochim. Biophys. Acta, 463:347.Google Scholar
  36. Williams, R.J.P., 1978, The multifarious couplings of energy transduction, Biochim. Biophys. Acta, 505:1.Google Scholar

Copyright information

© Springer Science+Business Media New York 1980

Authors and Affiliations

  • R. A. Capaldi
    • 1
  • L. Prochaska
    • 1
  • R. Bisson
    • 1
  1. 1.Institute of Molecular BiologyUniversity of OregonEugeneUSA

Personalised recommendations