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Biological Response Modifiers in Human Oncology and Immunology pp 23–35Cite as

Interferon Hybrids: Prospects for Therapy

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 166))

Abstract

Recombinant DNA techniques have led to determination of the structure of human interferons and production of individual molecular species of interferon free from other species and other proteins simultaneously induced in human cell cultures. Comparison of the properties of different molecular species of interferon and molecular hybrids between the various species has indicated the extent to which the various biological properties of interferons may be separated. This information provides a basis for considering the design of particular molecular constructions of interferons with particular desired properties. The production of hybrid interferons from different genes with common restriction enzyme sites provides a method for producing desirable analogs. The current data are here reviewed with respect to potential clinical utility of such materials.

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Author information

Authors and Affiliations

  1. AMGen, Inc., 1900 Oak Terrace Lane, Thousand Oaks, CA, USA

    Nowell Stebbing

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  1. Nowell Stebbing
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Editor information

Editors and Affiliations

  1. University of South Florida, Tampa, Florida, USA

    Thomas Klein , Steven Specter , Herman Friedman  & Andor Szentivanyi , ,  & 

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© 1983 Springer Science+Business Media New York

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Stebbing, N. (1983). Interferon Hybrids: Prospects for Therapy. In: Klein, T., Specter, S., Friedman, H., Szentivanyi, A. (eds) Biological Response Modifiers in Human Oncology and Immunology. Advances in Experimental Medicine and Biology, vol 166. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-1410-4_3

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  • DOI: https://doi.org/10.1007/978-1-4757-1410-4_3

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4757-1412-8

  • Online ISBN: 978-1-4757-1410-4

  • eBook Packages: Springer Book Archive

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