A Feasibility Study to Determine if Microbicidal Activity can be Measured in Dexamethasone-Treated Macrophage Cultures
Macrophages play a major role in host resistance by ingesting and killing microorganisms. If these normal phagocytic processes are impaired by chemotherapeutic agents, host resistance decreases and susceptibility to infectious diseases increases accordingly. This may be the case with the glucocorticoid steroids since these agents suppress other macrophage functions (1,6,7). However, whether glucocorticoids act directly on macrophages in vivo to reduce host resistance by inhibiting their normal phagocytic functions remains to be established.
KeywordsMacrophage Culture Murine Peritoneal Macrophage Phagocytosis Assay Viable Yeast Intracellular Killing
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